Novel synthesis of [1]-benzothiepino[5,4-b]pyridine-3-carbonitriles and their anti-inflammatory properties

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 6, 2007, Pages 2403-2413

  Girgis, Adel S ^a   Mishriky, Nawal ^a   Ellithey, Mohey ^a   Hosni, Hanaa M ^a   Farag, Hanaa ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

4 Arylmethylene 3,4 dihydro 1 benzothiepin 5(2H) ones; 1 Benzothiepino 5,4 b pyridine 3 carbonitriles; Anti inflammatory; Ylidenecyanothioacetamides; Ylidenemalononitriles

Indexed keywords

3 CYANO 5,6 DIHYDRO 4 (4 METHOXYPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 2 (1H)THIONE; 4 (4 BROMOPHENYL) 3 CYANO 5,6 DIHYDRO [1] BENZOTHIEPINO[5,4 B]PYRIDINE 2 (1H)THIONE; 4 (4 BROMOPHENYL) 5,6 DIHYDRO 2 ETHOXY [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 4 (4 BROMOPHENYL) 5,6 DIHYDRO 2 METHOXY [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 4 (4 CHLOROPHENYL) 5,6 DIHYDRO 2 ETHOXY [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 4 (4 CHLOROPHENYL) 5,6 DIHYDRO 2 METHOXY [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 ETHOXY 4 (4 FLUOROPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 ETHOXY 4 (4 METHOXYPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 ETHOXY 4 (4 METHYLPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 ETHOXY 4 PHENYL [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 METHOXY 4 (2 THIENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 METHOXY 4 (4 METHOXYPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 METHOXY 4 (4 METHYLPHENYL) [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 2 METHOXY 4 PHENYL [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 4 (2 FURANYL) 2 METHOXY [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; 5,6 DIHYDRO 4 (4 FLUOROPHENYL) 2 METHOXY 4 PHENYL [1] BENZOTHIEPINO[5,4 B]PYRIDINE 3 CARBONITRILE; ACETAMIDE DERIVATIVE; ANTIINFLAMMATORY AGENT; CYANIDE; CYANOTHIOACETAMIDE; INDOMETACIN; MORPHOLINE; MORPHOLINIUM 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 THIOXO 2 (1H) PYRIDINETHIOLATE MONOHYDRATE; MORPHOLINIUM 4 (4 CHLOROPHENYL) 3,5 DICYANO 6 THIOXO 2 (1H) PYRIDINETHIOLATE MONOHYDRATE; MORPHOLINIUM 6 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 2 PYRIDINETHIOLATE; PIPERIDINE; PIPERIDINIUM 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 THIOXO 2 (1H) PYRIDINETHIOLATE MONOHYDRATE; PIPERIDINIUM 4 (4 CHLOROPHENYL) 3,5 DICYANO 6 THIOXO 2 (1H) PYRIDINETHIOLATE MONOHYDRATE; PIPERIDINIUM 6 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 2 PYRIDINETHIOLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; PAW EDEMA; RAT; X RAY DIFFRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOTHIEPINS; CARRAGEENAN; EDEMA; FEMALE; MALE; MOLECULAR STRUCTURE; NITRILES; PYRIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 33846936851     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.015     Document Type: Article

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