Synthesis of new 3-pyridinecarboxylates of potential vasodilation properties

European Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2008, Pages 1818-1827

  Girgis, Adel S ^a   Mishriky, Nawal ^a   Farag, Ahmad M ^b   El Eraky, Wafaa I ^a   Farag, Hanaa ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

2 Propen 1 ones; 3 Pyridinecarboxylates; Aromatic nucleophilic substitution; Vasodilation

Indexed keywords

1,4 BIS[[ETHYL 4 (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXYLATE] 2 YL]PIPERAZINE; 2 BROMO 3 PYRIDINECARBOXYLIC ACID DERIVATIVE; 3 PYRIDINECARBOXYLIC ACID DERIVATIVE; ANILINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CICLONICATE; ETHYL 2 [(4 METHOXYPHENYL)AMINO] 4 (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXYLATE; ETHYL 4 (4 FLUOROPHENYL) 2 (4 MORPHOLINYL) 6 PHENYL 3 PYRIDINECARBOXYLATE; ETHYL 4 (4 METHYLPHENYL) 6 PHENYL 2 (1 PIPERIDINYL) 3 PYRIDINECARBOXYLATE; HEPRONICATE; INOSITOL NICOTINATE; MORPHOLINE; NICAMETATE; NORADRENALIN; PIPERIDINE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BROMINATION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; RAT; REDUCTION KINETICS; SUBSTITUTION REACTION; THORACIC AORTA; VASCULAR RING; VASODILATATION;

ANIMALS; CARBOXYLIC ACIDS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MALE; NICOTINIC ACIDS; NOREPINEPHRINE; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATION; VASODILATOR AGENTS;

EID: 50949129548     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.11.025     Document Type: Article

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