Regioselective synthesis and stereochemical structure of anti-tumor active dispiro[3H-indole-3,2′-pyrrolidine-3′,3″-piperidine]-2(1H),4″-diones

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1257-1264

  Girgis, Adel S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

3,5 Bis(arylmethylene) 1 methyl 4 piperidinones; Anti inflammatory; Anti tumor; Azomethine ylides; Dispiro 3H indole 3,2 pyrrolidine 3 ,3 piperidine 2(1H),4 diones

Indexed keywords

1',1'' DIMETHYL 4' (2 THIENYL) 5'' [(2 THIENYL)METHYLENE] DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 1',1'' DIMETHYL 4' (4 FLUOROPHENYL) 5'' [(4 FLUOROPHENYL)METHYLENE] DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 1',1'' DIMETHYL 4' (4 METHOXYPHENYL) 5'' [(4 METHOXYPHENYL)METHYLENE] DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 1',1'' DIMETHYL 4' (4 METHYLPHENYL) 5'' [(4 METHYLPHENYL)METHYLENE] DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 3,5 BIS(ARYLMETHYLENE) 1 METHYL 4 PIPERIDINONE DERIVATIVE; 4' (2 THIENYL) 5'' [(2 THIENYL)METHYLENE] 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 BROMOPHENYL) 5'' [(4 BROMOPHENYL)METHYLENE] 1',1'' DIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 BROMOPHENYL) 5'' [(4 BROMOPHENYL)METHYLENE] 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 CHLOROPHENYL) 5'' [(4 CHLOROPHENYL)METHYLENE] 1',1'' DIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 CHLOROPHENYL) 5'' [(4 CHLOROPHENYL)METHYLENE] 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2'' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 FLUOROPHENYL) 5'' [(4 FLUOROPHENYL)METHYLENE] 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' (4 METHYLPHENYL) 5'' [(4 METHYLPHENYL)METHYLENE] 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2'' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; 4' ARYL 5'' (ARYLMETHYLENE)DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE DERIVATIVE; 4' PHENYL 5'' (PHENYLMETHYLENE) 1,1',1'' TRIMETHYL DISPIRO[3H INDOLE 3,2' PYRROLIDINE 3',3'' PIPERIDINE] 2 (1H),4'' DIONE; ALCOHOL; ANTINEOPLASTIC AGENT; AZOMETHINE YLIDE; INDOMETACIN; ISATIN DERIVATIVE; PIPERIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CANCER; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA; LUNG CANCER; MELANOMA; NONHUMAN; OVARY CANCER; PAW EDEMA; POLYMERIZATION; PROSTATE CANCER; RAT; STEREOCHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; PIPERIDINES; PYRROLIDINES; RATS; RATS, WISTAR;

EID: 60549090802     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.007     Document Type: Article

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