Novel synthesis of nicotinamide derivatives of cytotoxic properties

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 13, 2006, Pages 4466-4476

  Girgis, Adel S ^a   Hosni, Hanaa M ^a   Barsoum, Flora F ^b  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

2 Propen 1 ones; 3 Pyridinecarboxamides; Aromatic nucleophilic substitution; Cyanacetanilides; Michael reaction

Indexed keywords

2 [(4 CHLOROPHENYL)AMINO] 4 (4 METHYLPHENYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 2 AMINO 4 (4 CHLOROPHENYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 2 AMINO 4 (4 CHLOROPHENYL) N (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXAMIDE; 2 AMINO 4 (4 METHYLPHENYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 2 BROMO 4 (4 CHLOROPHENYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 2 BROMO 4 (4 CHLOROPHENYL) N (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXAMIDE; 2 BROMO 4 (4 METHYLPHENYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 2 CYANO 3 (4 METHYLPHENYL) 5 OXO 5 PHENYL N PHENYLPENTAMIDE; 3 (4 CHLOROPHENYL) 2 CYANO 5 OXO 5 PHENYL N PHENYLPENTAMIDE; 3 (4 CHLOROPHENYL) 2 CYANO N (4 METHYLPHENYL) 5 OXO 5 PHENYLPENTAMIDE; 4 (4 CHLOROPHENYL) 2 (4 MORPHOLINYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 2 [(4 CHLOROPHENYL)AMINO] 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 2 [(4 CHLOROPHENYL)AMINO] N (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 2 [(4 METHOXYPHENYL)AMINO] 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 2 [(4 METHOXYPHENYL)AMINO] N (4 METHYLPHENYL) 6 PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 2 [(4 METHYLPHENYL)AMINO] 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 6 PHENYL N PHENYL 2 (1 PIPERIDINYL) 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) 6 PHENYL N PHENYL 2 (PHENYLAMINO) 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) N (4 METHYLPHENYL) 2 (4 MORPHOLINYL) 6 PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) N (4 METHYLPHENYL) 2 [(4 METHYLPHENYL)AMINO] 6 PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 CHLOROPHENYL) N (4 METHYLPHENYL) 6 PHENYL 2 (1 PIPERIDINYL) 3 PYRIDINECARBOXAMIDE; 4 (4 METHYLPHENYL) 2 (4 MORPHOLINYL) 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 METHYLPHENYL) 2 [(4 METHYLPHENYL)AMINO] 6 PHENYL N PHENYL 3 PYRIDINECARBOXAMIDE; 4 (4 METHYLPHENYL) 6 PHENYL N PHENYL 2 (1 PIPERIDINYL) 3 PYRIDINECARBOXAMIDE; ACETANILIDE DERIVATIVE; ACETIC ACID; CYANACETANILIDE; NICOTINAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BROMINATION; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICHAEL ADDITION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; NIACINAMIDE;

EID: 33646560008     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.02.031     Document Type: Article

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