Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8151-8160

  Dong, Xiaowu ^a   Liu, Yujie ^a   Yan, Jingying ^a   Jiang, Chaoyi ^a   Chen, Jing ^a   Liu, Tao ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Classification model; Prenylated flavonoids; Support vector machine; Vasorelaxation

Indexed keywords

2,4,6 TRIHYDROXY 3',4' METHYLENEDIOXY 3 (3,3 DIMETHYLALLYL)CHALCONE; 2,4,6 TRIHYDROXY 3',4',5' TRIMETHOXYL 3 (3,3 DIMETHYLALLYL)CHALCONE; 2,4,6 TRIHYDROXY 4' CHLORO 3 (3,3 DIMETHYLALLYL)CHALCONE; 5,7 DIHYDROXY 3' BROMO 8 (3,3 DIMETHYLALLYL)FLAVANONE; 5,7 DIHYDROXY 3' HYDROXY 8 (3,3 DIMETHYLALLYL)FLAVONE; 5,7 DIHYDROXY 3',4' METHYLENEDIOXY 8 (3,3 DIMETHYLALLYL)FLAVANONE; 5,7 DIHYDROXY 3',4',5' TRIMETHOXY 8 (3,3 DIMETHYLALLYL)FLAVONE; 5,7,4' TRIHYDROXY 3' METHOXY 8 (3,3 DIMETHYLALLYL)FLAVONE; CHALCONE; EXIGUAFLAVANONE; FLAVANONE DERIVATIVE; FLAVONE; FLAVONOID; GALABRANIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PRENYLATION; RAT; STRUCTURE ACTIVITY RELATION; SUPPORT VECTOR MACHINE; VASODILATATION;

ALGORITHMS; ANIMALS; AORTA, THORACIC; COMPUTER SIMULATION; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; MALE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; ORGAN CULTURE TECHNIQUES; PHENYLEPHRINE; PREDICTIVE VALUE OF TESTS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

RATTUS;

EID: 50349091195     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.031     Document Type: Article

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