HZwint-1 bridges the inner and outer kinetochore: Identification of the kinetochore localization domain and the hZw10-interaction domain

Biochemical Journal

Volumn 436, Issue 1, 2011, Pages 157-168

  Vos, Larissa J ^a   Famulski, Jakub K ^a   Chan, Gordon K T ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

Author keywords

Centromere; Kinetochore; Mitosis; Mitotic checkpoint; Zw10 interacting protein 1 (Zwint 1); Zwl0

Indexed keywords

PROTEIN; PROTEIN HZWINT 1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTROMERE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETOCHORES; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS;

EID: 79955531150     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110137     Document Type: Article

References (45)

1. Nicklas, R. B. (1997) How cells get the right chromosomes. Science 275, 632-637
2. Rieder, C. L., Schultz, A., Cole, R. and Sluder, G. (1994) Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127, 1301-1310 (Pubitemid 24362564)
3. King, R. W., Peters, J. M., Tugendreich, S., Rolfe, M., Hieter, P. and Kirschner, M. W. (1995) A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288
4. Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F. C., Ruderman, J. V. and Hershko, A. (1995) The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-197
5. Bharadwaj, R. and Yu, H. (2004) The spindle checkpoint, aneuploidy, and cancer. Oncogene 23, 2016-2027 (Pubitemid 38496731)
6. Earnshaw, W. C. and Rothfield, N. (1985) Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91, 313-321 (Pubitemid 15106904)
7. Foltz, D. R., Jansen, L. E., Black, B. E., Bailey, A. O., Yates, 3rd, J. R. and Cleveland, D. W. (2006) The human CENP-A centromeric nucleosome- associated complex. Nat. Cell Biol. 8, 458-469
8. Hori, T., Amano, M., Suzuki, A., Backer, C. B., Welburn, J. P., Dong, Y., McEwen, B. F., Shang, W. H., Suzuki, E., Okawa, K. et al. (2008) CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell 135, 1039-1052
9. Okada, M., Cheeseman, I. M., Hori, T., Okawa, K., McLeod, I. X., Yates, 3rd, J. R., Desai, A. and Fukagawa, T. (2006) The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat. Cell Biol. 8, 446-457
10. Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M. and Desai, A. (2006) The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127, 983-997 (Pubitemid 44792248)
11. Kiyomitsu, T., Obuse, C. and Yanagida, M. (2007) Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev. Cell 13, 663-676 (Pubitemid 350019284)
12. Petrovic, A., Pasqualato, S., Dube, P., Krenn, V., Santaguida, S., Cittaro, D., Monzani, S., Massimiliano, L., Keller, J., Tarricone, A. et al. (2010) The MIS12 complex is a protein interaction hubfor outer kinetochore assembly. J. Cell Biol. 190, 835-852
13. Cheeseman, I. M., Hori, T., Fukagawa, T. and Desai, A. (2008) KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol. Biol. Cell 19, 587-594 (Pubitemid 351272147)
14. DeLuca, J. G., Gall, W. E., Ciferri, C., Cimini, D., Musacchio, A. and Salmon, E. D. (2006) Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127, 969-982 (Pubitemid 44792254)
15. DeLuca, J. G., Howell, B. J., Canman, J. C., Hickey, J. M., Fang, G. and Salmon, E. D. (2003) Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. Curr. Biol. 13, 2103-2109 (Pubitemid 37502528)
16. DeLuca, J. G., Moree, B., Hickey, J. M., Kilmartin, J. V. and Salmon, E. D. (2002) hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 159, 549-555
17. Janke, C., Ortiz, J., Lechner, J., Shevchenko, A., Magiera, M. M., Schramm, C. and Schiebel, E. (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J. 20, 777-791 (Pubitemid 32167642)
18. McCleland, M. L., Gardner, R. D., Kallio, M. J., Daum, J. R., Gorbsky, G. J., Burke, D. J. and Stukenberg, P. T. (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev. 17, 101-114 (Pubitemid 36062512)
19. Cheeseman, I. M., Niessen, S., Anderson, S., Hyndman, F., Yates, 3rd, J. R., Oegema, K. and Desai, A. (2004) A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18, 2255-2268 (Pubitemid 39209574)
20. Kline, S. L., Cheeseman, I. M., Hori, T., Fukagawa, T. and Desai, A. (2006) The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J. Cell Biol. 173, 9-17
21. Obuse, C., Iwasaki, O., Kiyomitsu, T., Goshima, G., Toyoda, Y. and Yanagida, M. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat. Cell Biol. 6, 1135-1141 (Pubitemid 39468016)
22. Joglekar, A. P., Bouck, D. C., Molk, J. N., Bloom, K. S. and Salmon, E. D. (2006) Molecular architecture of a kinetochore-microtubule attachment site. Nat. Cell Biol. 8, 581-585 (Pubitemid 43827350)
23. Hemmerich, P., Weidtkamp-Peters, S., Hoischen, C., Schmiedeberg, L., Erliandri, I. and Diekmann, S. (2008) Dynamics of inner kinetochore assembly and maintenance in living cells. J. Cell Biol. 180, 1101-1114 (Pubitemid 351468468)
24. Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K., Markowitz, S. D., Kinzler, K. W. and Vogelstein, B. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (Pubitemid 28155105)
25. Chan, G. K., Schaar, B. T. and Yen, T. J. (1998) Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J. Cell Biol. 143, 49-63 (Pubitemid 28480517)
26. Chen, R. H., Shevchenko, A., Mann, M. and Murray, A. W. (1998) Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J. Cell Biol. 143, 283-295 (Pubitemid 28487850)
27. Jablonski, S. A., Chan, G. K., Cooke, C. A., Earnshaw, W. C. and Yen, T. J. (1998) The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma 107, 386-396 (Pubitemid 29057531)
28. Li, Y. and Benezra, R. (1996) Identification of a human mitotic checkpoint gene: hsMAD2. Science 274, 246-248
29. Taylor, S. S., Ha, E. and McKeon, F. (1998) The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol. 142, 1-11 (Pubitemid 28341135)
30. Taylor, S. S. and McKeon, F. (1997) Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89, 727-735 (Pubitemid 27516175)
31. Sudakin, V., Chan, G. K. and Yen, T. J. (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol. 154, 925-936 (Pubitemid 34286173)
32. Howell, B. J., Moree, B., Farrar, E. M., Stewart, S., Fang, G. and Salmon, E. D. (2004) Spindle checkpoint protein dynamics at kinetochores in living cells. Curr. Biol. 14, 953-964 (Pubitemid 38722609)
33. Starr, D. A., Saffery, R., Li, Z., Simpson, A. E., Choo, K. H., Yen, T. J. and Goldberg, M. L. (2000) HZwint-1, a novel human kinetochore component that interacts with HZW10. J. Cell Sci. 113, 1939-1950 (Pubitemid 30386498)
34. Chan, G. K., Jablonski, S. A., Starr, D. A., Goldberg, M. L. and Yen, T. J. (2000) Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. Nat. Cell Biol. 2, 944-947
35. Williams, B. C., Li, Z., Liu, S., Williams, E. V., Leung, G., Yen, T. J. and Goldberg, M. L. (2003) Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Mol. Biol. Cell 14, 1379-1391 (Pubitemid 36547408)
36. Karess, R. (2005) Rod-Zw10-Zwilch: a key player in the spindle checkpoint. Trends Cell Biol. 15, 386-392 (Pubitemid 40943528)
37. Buffin, E., Lefebvre, C., Huang, J., Gagou, M. E. and Karess, R. E. (2005) Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex. Curr. Biol. 15, 856-861 (Pubitemid 40689406)
38. Starr, D. A., Williams, B. C., Hays, T. S. and Goldberg, M. L. (1998) ZW10 helps recruit dynactin and dynein to the kinetochore. J. Cell Biol. 142, 763-774 (Pubitemid 28381493)
39. Famulski, J. K., Vos, L., Sun, X. and Chan, G. (2008) Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint. J. Cell Biol. 180, 507-520 (Pubitemid 351240700)
40. Kops, G. J., Kim, Y, Weaver, B. A., Mao, Y, McLeod, I., Yates, 3rd, J. R., Tagaya, M. and Cleveland, D. W. (2005) ZW10 links mitotic checkpoint signaling to the structural kinetochore. J. Cell Biol. 169, 49-60 (Pubitemid 40562913)
41. Wang, H., Hu, X., Ding, X., Dou, Z., Yang, Z., Shaw, A. W., Teng, M., Cleveland, D. W., Goldberg, M. L., Niu, L. and Yao, X. (2004) Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J. Biol. Chem. 279, 54590-54598 (Pubitemid 40053202)
42. Lin, Y. T., Chen, Y., Wu, G. and Lee, W. H. (2006) Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. Oncogene 25, 6901-6914 (Pubitemid 44684831)
43. Liu, S. T., Chan, G. K., Hittle, J. C, Fujii, G., Lees, E. and Yen, T. J. (2003) Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-Efrom kinetochores. Mol. Biol. Cell 14, 1638-1651 (Pubitemid 36547428)
44. Hori, T., Haraguchi, T., Hiraoka, Y., Kimura, H. and Fukagawa, T. (2003) Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells. J. Cell Sci. 116, 3347-3362 (Pubitemid 37038983)
45. Hellwig, D., Munch, S., Orthaus, S., Hoischen, C., Hemmerich, P. and Diekmann, S. (2008) Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B. J. Biophotonics 1, 245-254