메뉴 건너뛰기




Volumn 31, Issue 2, 2011, Pages 175-190

Mechanisms of Subcutaneous Allergen Immunotherapy

Author keywords

Allergen immunotherapy; Allergy; Immune tolerance; Interleukin 10; T regulatory cells; Transforming growth factor

Indexed keywords

ALLERGEN; BEE VENOM; FC RECEPTOR; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

EID: 79955438078     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.iac.2011.02.006     Document Type: Review
Times cited : (37)

References (130)
  • 1
    • 47949107183 scopus 로고    scopus 로고
    • The development of allergic inflammation
    • Galli S.J., Tsai M., Piliponsky A.M. The development of allergic inflammation. Nature 2008, 454(7203):445-454.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 445-454
    • Galli, S.J.1    Tsai, M.2    Piliponsky, A.M.3
  • 2
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larche M., Akdis C.A., Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006, 6(10):761-771.
    • (2006) Nat Rev Immunol , vol.6 , Issue.10 , pp. 761-771
    • Larche, M.1    Akdis, C.A.2    Valenta, R.3
  • 3
    • 34047163404 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis M., Akdis C.A. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007, 119(4):780-791.
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.4 , pp. 780-791
    • Akdis, M.1    Akdis, C.A.2
  • 4
    • 72449183606 scopus 로고    scopus 로고
    • Histamine, histamine receptors and their role in immune pathology
    • Jutel M., Akdis M., Akdis C.A. Histamine, histamine receptors and their role in immune pathology. Clin Exp Allergy 2009, 39(12):1786-1800.
    • (2009) Clin Exp Allergy , vol.39 , Issue.12 , pp. 1786-1800
    • Jutel, M.1    Akdis, M.2    Akdis, C.A.3
  • 5
    • 52249118345 scopus 로고    scopus 로고
    • Regulatory effects of histamine and histamine receptor expression in human allergic immune responses
    • Akdis C.A., Jutel M., Akdis M. Regulatory effects of histamine and histamine receptor expression in human allergic immune responses. Chem Immunol Allergy 2008, 94:67-82.
    • (2008) Chem Immunol Allergy , vol.94 , pp. 67-82
    • Akdis, C.A.1    Jutel, M.2    Akdis, M.3
  • 6
    • 79952291528 scopus 로고    scopus 로고
    • Interleukins from 1 to 37 and interferon-gamma
    • e70
    • Akdis M., Burgler S., Crameri R., et al. Interleukins from 1 to 37 and interferon-gamma. J Allergy Clin Immunol 2011, 127:701-721. e70.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 701-721
    • Akdis, M.1    Burgler, S.2    Crameri, R.3
  • 8
    • 33750350343 scopus 로고    scopus 로고
    • Allergy and hypersensitivity: mechanisms of allergic disease
    • Akdis C.A. Allergy and hypersensitivity: mechanisms of allergic disease. Curr Opin Immunol 2006, 18(6):718-726.
    • (2006) Curr Opin Immunol , vol.18 , Issue.6 , pp. 718-726
    • Akdis, C.A.1
  • 9
    • 2942685507 scopus 로고    scopus 로고
    • Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    • Akdis M., Verhagen J., Taylor A., et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004, 199(11):1567-1575.
    • (2004) J Exp Med , vol.199 , Issue.11 , pp. 1567-1575
    • Akdis, M.1    Verhagen, J.2    Taylor, A.3
  • 10
    • 65349119355 scopus 로고    scopus 로고
    • Development and function of TH17 cells in health and disease
    • Louten J., Boniface K., de Waal Malefyt R. Development and function of TH17 cells in health and disease. J Allergy Clin Immunol 2009, 123(5):1004-1011.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.5 , pp. 1004-1011
    • Louten, J.1    Boniface, K.2    de Waal Malefyt, R.3
  • 11
    • 77956247181 scopus 로고    scopus 로고
    • The cellular orchestra in skin allergy; are differences to lung and nose relevant?
    • Akdis M. The cellular orchestra in skin allergy; are differences to lung and nose relevant?. Curr Opin Allergy Clin Immunol 2010, 10(5):443-451.
    • (2010) Curr Opin Allergy Clin Immunol , vol.10 , Issue.5 , pp. 443-451
    • Akdis, M.1
  • 12
    • 61549130932 scopus 로고    scopus 로고
    • Differentiation and functional analysis of human T(H)17 cells
    • e581-7
    • Burgler S., Ouaked N., Bassin C., et al. Differentiation and functional analysis of human T(H)17 cells. J Allergy Clin Immunol 2009, 123(3):588-595. e581-7.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.3 , pp. 588-595
    • Burgler, S.1    Ouaked, N.2    Bassin, C.3
  • 13
    • 65349113679 scopus 로고    scopus 로고
    • T cells in health and disease
    • Akdis C.A. T cells in health and disease. J Allergy Clin Immunol 2009, 123(5):1022-1023.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.5 , pp. 1022-1023
    • Akdis, C.A.1
  • 14
    • 69349097543 scopus 로고    scopus 로고
    • Unmet needs in severe chronic upper airway disease (SCUAD)
    • Bousquet J., Bachert C., Canonica G.W., et al. Unmet needs in severe chronic upper airway disease (SCUAD). J Allergy Clin Immunol 2009, 124(3):428-433.
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.3 , pp. 428-433
    • Bousquet, J.1    Bachert, C.2    Canonica, G.W.3
  • 15
    • 78049465373 scopus 로고    scopus 로고
    • Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial
    • Zielen S., Kardos P., Madonini E. Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial. J Allergy Clin Immunol 2010, 126(5):942-949.
    • (2010) J Allergy Clin Immunol , vol.126 , Issue.5 , pp. 942-949
    • Zielen, S.1    Kardos, P.2    Madonini, E.3
  • 16
    • 77951717543 scopus 로고    scopus 로고
    • Role of Treg in immune regulation of allergic diseases
    • Palomares O., Yaman G., Azkur A.K., et al. Role of Treg in immune regulation of allergic diseases. Eur J Immunol 2010, 40(5):1232-1240.
    • (2010) Eur J Immunol , vol.40 , Issue.5 , pp. 1232-1240
    • Palomares, O.1    Yaman, G.2    Azkur, A.K.3
  • 17
    • 68249141746 scopus 로고    scopus 로고
    • Therapeutic manipulation of immune tolerance in allergic disease
    • Akdis M., Akdis C.A. Therapeutic manipulation of immune tolerance in allergic disease. Nat Rev Drug Discov 2009, 8(8):645-660.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.8 , pp. 645-660
    • Akdis, M.1    Akdis, C.A.2
  • 18
    • 78650902704 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis C.A., Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011, 127:18-27.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 18-27
    • Akdis, C.A.1    Akdis, M.2
  • 19
    • 70449497750 scopus 로고    scopus 로고
    • Immune tolerance in allergy
    • Akdis M. Immune tolerance in allergy. Curr Opin Immunol 2009, 21(6):700-707.
    • (2009) Curr Opin Immunol , vol.21 , Issue.6 , pp. 700-707
    • Akdis, M.1
  • 20
    • 64649093157 scopus 로고    scopus 로고
    • T regulatory cells and their counterparts: masters of immune regulation
    • Ozdemir C., Akdis M., Akdis C.A. T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 2009, 39(5):626-639.
    • (2009) Clin Exp Allergy , vol.39 , Issue.5 , pp. 626-639
    • Ozdemir, C.1    Akdis, M.2    Akdis, C.A.3
  • 21
    • 53049107609 scopus 로고    scopus 로고
    • New insights into mechanisms of immunoregulation in 2007
    • Akdis C.A. New insights into mechanisms of immunoregulation in 2007. J Allergy Clin Immunol 2008, 122(4):700-709.
    • (2008) J Allergy Clin Immunol , vol.122 , Issue.4 , pp. 700-709
    • Akdis, C.A.1
  • 22
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • Jutel M., Akdis M., Budak F., et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003, 33(5):1205-1214.
    • (2003) Eur J Immunol , vol.33 , Issue.5 , pp. 1205-1214
    • Jutel, M.1    Akdis, M.2    Budak, F.3
  • 23
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler F., Zumkehr J., Klunker S., et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008, 205(12):2887-2898.
    • (2008) J Exp Med , vol.205 , Issue.12 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3
  • 24
    • 1342308180 scopus 로고    scopus 로고
    • Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    • Ling E.M., Smith T., Nguyen X.D., et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004, 363(9409):608-615.
    • (2004) Lancet , vol.363 , Issue.9409 , pp. 608-615
    • Ling, E.M.1    Smith, T.2    Nguyen, X.D.3
  • 25
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299(5609):1057-1061.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 26
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett C.L., Christie J., Ramsdell F., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27(1):20-21.
    • (2001) Nat Genet , vol.27 , Issue.1 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 27
    • 61449212006 scopus 로고    scopus 로고
    • Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells
    • Siegmund K., Ruckert B., Ouaked N., et al. Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells. J Immunol 2009, 182(4):2124-2130.
    • (2009) J Immunol , vol.182 , Issue.4 , pp. 2124-2130
    • Siegmund, K.1    Ruckert, B.2    Ouaked, N.3
  • 28
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • Wildin R.S., Smyk-Pearson S., Filipovich A.H. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 2002, 39(8):537-545.
    • (2002) J Med Genet , vol.39 , Issue.8 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 29
    • 57249097253 scopus 로고    scopus 로고
    • Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between Forkhead box protein 3 expression and disease severity
    • e1
    • Gambineri E., Perroni L., Passerini L., et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between Forkhead box protein 3 expression and disease severity. J Allergy Clin Immunol 2008, 122(6):1105-1112. e1.
    • (2008) J Allergy Clin Immunol , vol.122 , Issue.6 , pp. 1105-1112
    • Gambineri, E.1    Perroni, L.2    Passerini, L.3
  • 30
    • 63449090874 scopus 로고    scopus 로고
    • Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    • [quiz: 747-8]
    • Akdis C.A., Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009, 123(4):735-746. [quiz: 747-8].
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.4 , pp. 735-746
    • Akdis, C.A.1    Akdis, M.2
  • 31
    • 29544440569 scopus 로고    scopus 로고
    • Absence of T-regulatory cell expression and function in atopic dermatitis skin
    • Verhagen J., Akdis M., Traidl-Hoffmann C., et al. Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol 2006, 117(1):176-183.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.1 , pp. 176-183
    • Verhagen, J.1    Akdis, M.2    Traidl-Hoffmann, C.3
  • 32
    • 68249113115 scopus 로고    scopus 로고
    • Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis
    • Ito Y., Adachi Y., Makino T., et al. Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis. Ann Allergy Asthma Immunol 2009, 103(2):160-165.
    • (2009) Ann Allergy Asthma Immunol , vol.103 , Issue.2 , pp. 160-165
    • Ito, Y.1    Adachi, Y.2    Makino, T.3
  • 33
    • 78650879440 scopus 로고    scopus 로고
    • TWEAK and TNF-alpha cooperate in the induction of keratinocyte apoptosis
    • e1-10
    • Zimmermann M., Koreck A., Meyer N., et al. TWEAK and TNF-alpha cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol 2011, 127:200-207. e1-10.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 200-207
    • Zimmermann, M.1    Koreck, A.2    Meyer, N.3
  • 34
    • 77957843236 scopus 로고    scopus 로고
    • Increased airway T regulatory cells in asthmatic subjects
    • Smyth L.J., Eustace A., Kolsum U., et al. Increased airway T regulatory cells in asthmatic subjects. Chest 2010, 138(4):905-912.
    • (2010) Chest , vol.138 , Issue.4 , pp. 905-912
    • Smyth, L.J.1    Eustace, A.2    Kolsum, U.3
  • 35
    • 20844432359 scopus 로고    scopus 로고
    • Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
    • Karagiannidis C., Akdis M., Holopainen P., et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol 2004, 114(6):1425-1433.
    • (2004) J Allergy Clin Immunol , vol.114 , Issue.6 , pp. 1425-1433
    • Karagiannidis, C.1    Akdis, M.2    Holopainen, P.3
  • 36
    • 70350278741 scopus 로고    scopus 로고
    • Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ population
    • Anderson A.E., Mackerness K.J., Aizen M., et al. Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ population. Clin Exp Allergy 2009, 39(11):1693-1699.
    • (2009) Clin Exp Allergy , vol.39 , Issue.11 , pp. 1693-1699
    • Anderson, A.E.1    Mackerness, K.J.2    Aizen, M.3
  • 37
    • 38449083590 scopus 로고    scopus 로고
    • Resolution of Der p1-induced allergic airway inflammation is dependent on CD4+CD25+Foxp3+ regulatory cells
    • Leech M.D., Benson R.A., De Vries A., et al. Resolution of Der p1-induced allergic airway inflammation is dependent on CD4+CD25+Foxp3+ regulatory cells. J Immunol 2007, 179(10):7050-7058.
    • (2007) J Immunol , vol.179 , Issue.10 , pp. 7050-7058
    • Leech, M.D.1    Benson, R.A.2    De Vries, A.3
  • 38
    • 77956402033 scopus 로고    scopus 로고
    • T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice
    • Jones T.G., Finkelman F.D., Austen K.F., et al. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol 2010, 185(3):1804-1811.
    • (2010) J Immunol , vol.185 , Issue.3 , pp. 1804-1811
    • Jones, T.G.1    Finkelman, F.D.2    Austen, K.F.3
  • 39
    • 39149120840 scopus 로고    scopus 로고
    • Analysis of CD25hiCD4+ "regulatory" T-cell subtypes in atopic dermatitis reveals a novel T(H)2-like population
    • e3
    • Reefer A.J., Satinover S.M., Solga M.D., et al. Analysis of CD25hiCD4+ "regulatory" T-cell subtypes in atopic dermatitis reveals a novel T(H)2-like population. J Allergy Clin Immunol 2008, 121(2):415-422. e3.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.2 , pp. 415-422
    • Reefer, A.J.1    Satinover, S.M.2    Solga, M.D.3
  • 40
    • 34347220902 scopus 로고    scopus 로고
    • Association between CD4(+)CD25(high) T cells and atopy in children
    • Jartti T., Burmeister K.A., Seroogy C.M., et al. Association between CD4(+)CD25(high) T cells and atopy in children. J Allergy Clin Immunol 2007, 120(1):177-183.
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.1 , pp. 177-183
    • Jartti, T.1    Burmeister, K.A.2    Seroogy, C.M.3
  • 41
    • 49249110951 scopus 로고    scopus 로고
    • T-cell activation during exacerbations: a longitudinal study in refractory asthma
    • Mamessier E., Nieves A., Lorec A.M., et al. T-cell activation during exacerbations: a longitudinal study in refractory asthma. Allergy 2008, 63(9):1202-1210.
    • (2008) Allergy , vol.63 , Issue.9 , pp. 1202-1210
    • Mamessier, E.1    Nieves, A.2    Lorec, A.M.3
  • 42
    • 34548699169 scopus 로고    scopus 로고
    • Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals
    • Maggi L., Santarlasci V., Liotta F., et al. Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals. J Allergy Clin Immunol 2007, 120(2):429-436.
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.2 , pp. 429-436
    • Maggi, L.1    Santarlasci, V.2    Liotta, F.3
  • 43
    • 50549092067 scopus 로고    scopus 로고
    • Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma
    • Nguyen K.D., Vanichsarn C., Nadeau K.C. Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma. Eur J Immunol 2008, 38(7):2034-2045.
    • (2008) Eur J Immunol , vol.38 , Issue.7 , pp. 2034-2045
    • Nguyen, K.D.1    Vanichsarn, C.2    Nadeau, K.C.3
  • 44
    • 23944501030 scopus 로고    scopus 로고
    • Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor
    • Bellinghausen I., Konig B., Bottcher I., et al. Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor. Immunology 2005, 116(1):103-111.
    • (2005) Immunology , vol.116 , Issue.1 , pp. 103-111
    • Bellinghausen, I.1    Konig, B.2    Bottcher, I.3
  • 45
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    • Karlsson M.R., Rugtveit J., Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004, 199(12):1679-1688.
    • (2004) J Exp Med , vol.199 , Issue.12 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 46
    • 77954309823 scopus 로고    scopus 로고
    • Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis
    • Han D., Wang C., Lou W., et al. Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis. Clin Immunol 2010, 136(2):292-301.
    • (2010) Clin Immunol , vol.136 , Issue.2 , pp. 292-301
    • Han, D.1    Wang, C.2    Lou, W.3
  • 47
    • 67749139559 scopus 로고    scopus 로고
    • Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma
    • McGee H.S., Agrawal D.K. Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma. Am J Respir Crit Care Med 2009, 180(3):211-225.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.3 , pp. 211-225
    • McGee, H.S.1    Agrawal, D.K.2
  • 48
    • 47249134619 scopus 로고    scopus 로고
    • Strategies for use of IL-10 or its antagonists in human disease
    • O'Garra A., Barrat F.J., Castro A.G., et al. Strategies for use of IL-10 or its antagonists in human disease. Immunol Rev 2008, 223:114-131.
    • (2008) Immunol Rev , vol.223 , pp. 114-131
    • O'Garra, A.1    Barrat, F.J.2    Castro, A.G.3
  • 49
    • 0032128421 scopus 로고    scopus 로고
    • Role of interleukin 10 in specific immunotherapy
    • Akdis C.A., Blesken T., Akdis M., et al. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998, 102(1):98-106.
    • (1998) J Clin Invest , vol.102 , Issue.1 , pp. 98-106
    • Akdis, C.A.1    Blesken, T.2    Akdis, M.3
  • 50
    • 51349120557 scopus 로고    scopus 로고
    • Nature of regulatory T cells in the context of allergic disease
    • Ozdemir C., Akdis M., Akdis C.A. Nature of regulatory T cells in the context of allergic disease. Allergy Asthma Clin Immunol 2008, 4(3):106-110.
    • (2008) Allergy Asthma Clin Immunol , vol.4 , Issue.3 , pp. 106-110
    • Ozdemir, C.1    Akdis, M.2    Akdis, C.A.3
  • 51
    • 28544444024 scopus 로고    scopus 로고
    • Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent
    • Kearley J., Barker J.E., Robinson D.S., et al. Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent. J Exp Med 2005, 202(11):1539-1547.
    • (2005) J Exp Med , vol.202 , Issue.11 , pp. 1539-1547
    • Kearley, J.1    Barker, J.E.2    Robinson, D.S.3
  • 52
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
    • De Waal Malefyt R., Abrams J., Bennett B., et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991, 174:1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3
  • 53
    • 34250843152 scopus 로고    scopus 로고
    • IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1
    • Taylor A., Akdis M., Joss A., et al. IL-10 inhibits CD28 and ICOS costimulations of T cells via src homology 2 domain-containing protein tyrosine phosphatase 1. J Allergy Clin Immunol 2007, 120(1):76-83.
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.1 , pp. 76-83
    • Taylor, A.1    Akdis, M.2    Joss, A.3
  • 54
    • 58149105644 scopus 로고    scopus 로고
    • Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells
    • Le T., Tversky J., Chichester K.L., et al. Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells. J Allergy Clin Immunol 2009, 123(1):217-223.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.1 , pp. 217-223
    • Le, T.1    Tversky, J.2    Chichester, K.L.3
  • 55
    • 77951667958 scopus 로고    scopus 로고
    • Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
    • e1118
    • Amu S., Saunders S.P., Kronenberg M., et al. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol 2010, 125(5):1114-1124. e1118.
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.5 , pp. 1114-1124
    • Amu, S.1    Saunders, S.P.2    Kronenberg, M.3
  • 56
    • 77956538422 scopus 로고    scopus 로고
    • Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    • Gregori S., Tomasoni D., Pacciani V., et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010, 116(6):935-944.
    • (2010) Blood , vol.116 , Issue.6 , pp. 935-944
    • Gregori, S.1    Tomasoni, D.2    Pacciani, V.3
  • 57
    • 76149089505 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
    • Cunha S.I., Pardali E., Thorikay M., et al. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J Exp Med 2010, 207(1):85-100.
    • (2010) J Exp Med , vol.207 , Issue.1 , pp. 85-100
    • Cunha, S.I.1    Pardali, E.2    Thorikay, M.3
  • 58
    • 2442707975 scopus 로고    scopus 로고
    • Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1
    • Shephard P., Martin G., Smola-Hess S., et al. Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol 2004, 164(6):2055-2066.
    • (2004) Am J Pathol , vol.164 , Issue.6 , pp. 2055-2066
    • Shephard, P.1    Martin, G.2    Smola-Hess, S.3
  • 59
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198(12):1875-1886.
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 60
    • 9144219649 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells
    • Huber S., Schramm C., Lehr H.A., et al. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol 2004, 173(11):6526-6531.
    • (2004) J Immunol , vol.173 , Issue.11 , pp. 6526-6531
    • Huber, S.1    Schramm, C.2    Lehr, H.A.3
  • 61
    • 77956546075 scopus 로고    scopus 로고
    • SMAD2 is essential for TGF beta-mediated Th17 cell generation
    • Malhotra N., Robertson E., Kang J. SMAD2 is essential for TGF beta-mediated Th17 cell generation. J Biol Chem 2010, 285(38):29044-29048.
    • (2010) J Biol Chem , vol.285 , Issue.38 , pp. 29044-29048
    • Malhotra, N.1    Robertson, E.2    Kang, J.3
  • 62
    • 73349115263 scopus 로고    scopus 로고
    • Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    • Klunker S., Chong M.M., Mantel P.Y., et al. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med 2009, 206(12):2701-2715.
    • (2009) J Exp Med , vol.206 , Issue.12 , pp. 2701-2715
    • Klunker, S.1    Chong, M.M.2    Mantel, P.Y.3
  • 63
    • 40049107712 scopus 로고    scopus 로고
    • Immunologic and inflammatory mechanisms that drive asthma progression to remodeling
    • [quiz: 571-2]
    • Broide D.H. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008, 121(3):560-570. [quiz: 571-2].
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.3 , pp. 560-570
    • Broide, D.H.1
  • 64
    • 67650752133 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    • Hackett T.L., Warner S.M., Stefanowicz D., et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009, 180(2):122-133.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.2 , pp. 122-133
    • Hackett, T.L.1    Warner, S.M.2    Stefanowicz, D.3
  • 65
    • 34249792354 scopus 로고    scopus 로고
    • Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice
    • Le A.V., Cho J.Y., Miller M., et al. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 2007, 178(11):7310-7316.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 7310-7316
    • Le, A.V.1    Cho, J.Y.2    Miller, M.3
  • 66
    • 17844400081 scopus 로고    scopus 로고
    • Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway
    • McMillan S.J., Xanthou G., Lloyd C.M. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol 2005, 174(9):5774-5780.
    • (2005) J Immunol , vol.174 , Issue.9 , pp. 5774-5780
    • McMillan, S.J.1    Xanthou, G.2    Lloyd, C.M.3
  • 67
    • 0035031745 scopus 로고    scopus 로고
    • Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen
    • Coutts A., Chen G., Stephens N., et al. Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen. Am J Physiol Lung Cell Mol Physiol 2001, 280(5):L999-L1008.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280 , Issue.5
    • Coutts, A.1    Chen, G.2    Stephens, N.3
  • 68
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • Wynn T.A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007, 117(3):524-529.
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 524-529
    • Wynn, T.A.1
  • 69
    • 0033378589 scopus 로고    scopus 로고
    • The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes
    • Lebman D.A., Edmiston J.S. The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes. Microbes Infect 1999, 1(15):1297-1304.
    • (1999) Microbes Infect , vol.1 , Issue.15 , pp. 1297-1304
    • Lebman, D.A.1    Edmiston, J.S.2
  • 70
    • 4344623276 scopus 로고    scopus 로고
    • TGF-beta receptor signaling is critical for mucosal IgA responses
    • Borsutzky S., Cazac B.B., Roes J., et al. TGF-beta receptor signaling is critical for mucosal IgA responses. J Immunol 2004, 173(5):3305-3309.
    • (2004) J Immunol , vol.173 , Issue.5 , pp. 3305-3309
    • Borsutzky, S.1    Cazac, B.B.2    Roes, J.3
  • 71
    • 71849089195 scopus 로고    scopus 로고
    • Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    • Presser K., Schwinge D., Wegmann M., et al. Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity. J Immunol 2008, 181(11):7751-7758.
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 7751-7758
    • Presser, K.1    Schwinge, D.2    Wegmann, M.3
  • 72
    • 0029820287 scopus 로고    scopus 로고
    • Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis C.A., Akdis M., Blesken T., et al. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J Clin Invest 1996, 98(7):1676-1683.
    • (1996) J Clin Invest , vol.98 , Issue.7 , pp. 1676-1683
    • Akdis, C.A.1    Akdis, M.2    Blesken, T.3
  • 73
    • 52249095519 scopus 로고    scopus 로고
    • T-cell regulatory mechanisms in specific immunotherapy
    • Jutel M., Akdis C.A. T-cell regulatory mechanisms in specific immunotherapy. Chem Immunol Allergy 2008, 94:158-177.
    • (2008) Chem Immunol Allergy , vol.94 , pp. 158-177
    • Jutel, M.1    Akdis, C.A.2
  • 74
    • 45549107012 scopus 로고    scopus 로고
    • T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches
    • Akdis M. T-cell tolerance to inhaled allergens: mechanisms and therapeutic approaches. Expert Opin Biol Ther 2008, 8(6):769-777.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.6 , pp. 769-777
    • Akdis, M.1
  • 75
    • 27644585757 scopus 로고    scopus 로고
    • T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases
    • [quiz: 969]
    • Akdis M., Blaser K., Akdis C.A. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005, 116(5):961-968. [quiz: 969].
    • (2005) J Allergy Clin Immunol , vol.116 , Issue.5 , pp. 961-968
    • Akdis, M.1    Blaser, K.2    Akdis, C.A.3
  • 76
    • 77956209086 scopus 로고    scopus 로고
    • Tracking antigen-specific T-cells during clinical tolerance induction in humans
    • Aslam A., Chan H., Warrell D.A., et al. Tracking antigen-specific T-cells during clinical tolerance induction in humans. PLoS One 2010, 5(6):e11028.
    • (2010) PLoS One , vol.5 , Issue.6
    • Aslam, A.1    Chan, H.2    Warrell, D.A.3
  • 77
    • 38349096223 scopus 로고    scopus 로고
    • Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy
    • Pereira-Santos M.C., Baptista A.P., Melo A., et al. Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy. Clin Exp Allergy 2008, 38(2):291-297.
    • (2008) Clin Exp Allergy , vol.38 , Issue.2 , pp. 291-297
    • Pereira-Santos, M.C.1    Baptista, A.P.2    Melo, A.3
  • 78
    • 44949122465 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa
    • e1461
    • Radulovic S., Jacobson M.R., Durham S.R., et al. Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa. J Allergy Clin Immunol 2008, 121(6):1467-1472. e1461.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.6 , pp. 1467-1472
    • Radulovic, S.1    Jacobson, M.R.2    Durham, S.R.3
  • 79
    • 84862833183 scopus 로고    scopus 로고
    • Induction of IL-10+ CD4+ CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy
    • Tsai Y.G., Chiou Y.L., Chien J.W., et al. Induction of IL-10+ CD4+ CD25+ regulatory T cells with decreased NF-kappaB expression during immunotherapy. Pediatr Allergy Immunol 2009, 21(1 Pt 2):e166-e173.
    • (2009) Pediatr Allergy Immunol , vol.21 , Issue.1 PART 2
    • Tsai, Y.G.1    Chiou, Y.L.2    Chien, J.W.3
  • 80
    • 68349125489 scopus 로고    scopus 로고
    • CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma
    • Boudousquie C., Pellaton C., Barbier N., et al. CD4+CD25+ T cell depletion impairs tolerance induction in a murine model of asthma. Clin Exp Allergy 2009, 39(9):1415-1426.
    • (2009) Clin Exp Allergy , vol.39 , Issue.9 , pp. 1415-1426
    • Boudousquie, C.1    Pellaton, C.2    Barbier, N.3
  • 81
    • 77949901839 scopus 로고    scopus 로고
    • Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation
    • Mobs C., Slotosch C., Loffler H., et al. Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J Immunol 2010, 184(4):2194-2203.
    • (2010) J Immunol , vol.184 , Issue.4 , pp. 2194-2203
    • Mobs, C.1    Slotosch, C.2    Loffler, H.3
  • 82
    • 33745666983 scopus 로고    scopus 로고
    • Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy
    • Mamessier E., Birnbaum J., Dupuy P., et al. Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy. Clin Exp Allergy 2006, 36(6):704-713.
    • (2006) Clin Exp Allergy , vol.36 , Issue.6 , pp. 704-713
    • Mamessier, E.1    Birnbaum, J.2    Dupuy, P.3
  • 83
    • 77953624351 scopus 로고    scopus 로고
    • TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy
    • Tsai Y.G., Yang K.D., Niu D.M., et al. TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy. J Immunol 2010, 184(12):7229-7237.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 7229-7237
    • Tsai, Y.G.1    Yang, K.D.2    Niu, D.M.3
  • 84
    • 10744232817 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    • Nouri-Aria K.T., Wachholz P.A., Francis J.N., et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 2004, 172(5):3252-3259.
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 3252-3259
    • Nouri-Aria, K.T.1    Wachholz, P.A.2    Francis, J.N.3
  • 85
    • 33947663099 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression
    • Pilette C., Nouri-Aria K.T., Jacobson M.R., et al. Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression. J Immunol 2007, 178(7):4658-4666.
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4658-4666
    • Pilette, C.1    Nouri-Aria, K.T.2    Jacobson, M.R.3
  • 86
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Muller U., Akdis C.A., Fricker M., et al. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 1998, 101(6 Pt 1):747-754.
    • (1998) J Allergy Clin Immunol , vol.101 , Issue.6 PART 1 , pp. 747-754
    • Muller, U.1    Akdis, C.A.2    Fricker, M.3
  • 87
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • Haselden B.M., Kay A.B., Larche M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 1999, 189(12):1885-1894.
    • (1999) J Exp Med , vol.189 , Issue.12 , pp. 1885-1894
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 88
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial
    • Oldfield W.L., Larche M., Kay A.B. Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 2002, 360(9326):47-53.
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 89
    • 33645301858 scopus 로고    scopus 로고
    • Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy
    • Tarzi M., Klunker S., Texier C., et al. Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy. Clin Exp Allergy 2006, 36(4):465-474.
    • (2006) Clin Exp Allergy , vol.36 , Issue.4 , pp. 465-474
    • Tarzi, M.1    Klunker, S.2    Texier, C.3
  • 90
    • 14344259699 scopus 로고    scopus 로고
    • IgE, IgG1, and IgG4 antibody responses to Blomia tropicalis in atopic patients
    • Pereira E.A., Silva D.A., Cunha-Junior J.P., et al. IgE, IgG1, and IgG4 antibody responses to Blomia tropicalis in atopic patients. Allergy 2005, 60(3):401-406.
    • (2005) Allergy , vol.60 , Issue.3 , pp. 401-406
    • Pereira, E.A.1    Silva, D.A.2    Cunha-Junior, J.P.3
  • 91
    • 0030975532 scopus 로고    scopus 로고
    • Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity
    • Zinkernagel R.M., Ehl S., Aichele P., et al. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev 1997, 156:199-209.
    • (1997) Immunol Rev , vol.156 , pp. 199-209
    • Zinkernagel, R.M.1    Ehl, S.2    Aichele, P.3
  • 92
    • 26944453183 scopus 로고    scopus 로고
    • Diagnosis of Hymenoptera venom allergy
    • Bilo B.M., Rueff F., Mosbech H., et al. Diagnosis of Hymenoptera venom allergy. Allergy 2005, 60(11):1339-1349.
    • (2005) Allergy , vol.60 , Issue.11 , pp. 1339-1349
    • Bilo, B.M.1    Rueff, F.2    Mosbech, H.3
  • 93
    • 76749113309 scopus 로고    scopus 로고
    • Structure and function of immunoglobulins
    • Schroeder H.W., Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol 2010, 125(2 Suppl 2):S41-S52.
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.2 SUPPL 2
    • Schroeder, H.W.1    Cavacini, L.2
  • 95
    • 77955922546 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific desensitization
    • Uermosi C., Beerli R.R., Bauer M., et al. Mechanisms of allergen-specific desensitization. J Allergy Clin Immunol 2010, 126(2):375-383.
    • (2010) J Allergy Clin Immunol , vol.126 , Issue.2 , pp. 375-383
    • Uermosi, C.1    Beerli, R.R.2    Bauer, M.3
  • 96
    • 0027324603 scopus 로고
    • T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2
    • Carballido J.M., Carballido-Perrig N., Kagi M.K., et al. T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2. J Immunol 1993, 150(8 Pt 1):3582-3591.
    • (1993) J Immunol , vol.150 , Issue.8 PART 1 , pp. 3582-3591
    • Carballido, J.M.1    Carballido-Perrig, N.2    Kagi, M.K.3
  • 97
    • 20044395467 scopus 로고    scopus 로고
    • Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood-report of the German Multicentre Allergy Study (MAS 90)
    • Lau S., Illi S., Platts-Mills T.A., et al. Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood-report of the German Multicentre Allergy Study (MAS 90). Allergy 2005, 60(6):766-773.
    • (2005) Allergy , vol.60 , Issue.6 , pp. 766-773
    • Lau, S.1    Illi, S.2    Platts-Mills, T.A.3
  • 98
    • 0034775387 scopus 로고    scopus 로고
    • Decreased prevalence of sensitization to cats with high exposure to cat allergen
    • Custovic A., Hallam C.L., Simpson B.M., et al. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol 2001, 108(4):537-539.
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.4 , pp. 537-539
    • Custovic, A.1    Hallam, C.L.2    Simpson, B.M.3
  • 99
    • 42749095525 scopus 로고    scopus 로고
    • Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
    • e1122
    • Francis J.N., James L.K., Paraskevopoulos G., et al. Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity. J Allergy Clin Immunol 2008, 121(5):1120-1125. e1122.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.5 , pp. 1120-1125
    • Francis, J.N.1    James, L.K.2    Paraskevopoulos, G.3
  • 100
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • Mothes N., Heinzkill M., Drachenberg K.J., et al. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 2003, 33(9):1198-1208.
    • (2003) Clin Exp Allergy , vol.33 , Issue.9 , pp. 1198-1208
    • Mothes, N.1    Heinzkill, M.2    Drachenberg, K.J.3
  • 101
    • 0043258973 scopus 로고    scopus 로고
    • Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy
    • Wachholz P.A., Soni N.K., Till S.J., et al. Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J Allergy Clin Immunol 2003, 112(5):915-922.
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.5 , pp. 915-922
    • Wachholz, P.A.1    Soni, N.K.2    Till, S.J.3
  • 102
    • 4143134268 scopus 로고    scopus 로고
    • Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes
    • Kepley C.L., Taghavi S., Mackay G., et al. Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes. J Biol Chem 2004, 279(34):35139-35149.
    • (2004) J Biol Chem , vol.279 , Issue.34 , pp. 35139-35149
    • Kepley, C.L.1    Taghavi, S.2    Mackay, G.3
  • 103
    • 77950956393 scopus 로고    scopus 로고
    • IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB
    • Cady C.T., Powell M.S., Harbeck R.J., et al. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett 2010, 130(1-2):57-65.
    • (2010) Immunol Lett , vol.130 , Issue.1-2 , pp. 57-65
    • Cady, C.T.1    Powell, M.S.2    Harbeck, R.J.3
  • 104
    • 0030991751 scopus 로고    scopus 로고
    • Effect of transmembrane and cytoplasmic domains of IgE on the IgE response
    • Achatz G., Nitschke L., Lamers M.C. Effect of transmembrane and cytoplasmic domains of IgE on the IgE response. Science 1997, 276(5311):409-411.
    • (1997) Science , vol.276 , Issue.5311 , pp. 409-411
    • Achatz, G.1    Nitschke, L.2    Lamers, M.C.3
  • 105
    • 8044234361 scopus 로고    scopus 로고
    • Measurement of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy
    • Van Ree R., Van Leeuwen W.A., Dieges P.H., et al. Measurement of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy. Clin Exp Allergy 1997, 27(1):68-74.
    • (1997) Clin Exp Allergy , vol.27 , Issue.1 , pp. 68-74
    • Van Ree, R.1    Van Leeuwen, W.A.2    Dieges, P.H.3
  • 106
    • 0019998115 scopus 로고
    • Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study
    • Gleich G.J., Zimmermann E.M., Henderson L.L., et al. Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study. J Allergy Clin Immunol 1982, 70(4):261-271.
    • (1982) J Allergy Clin Immunol , vol.70 , Issue.4 , pp. 261-271
    • Gleich, G.J.1    Zimmermann, E.M.2    Henderson, L.L.3
  • 107
    • 33747887028 scopus 로고    scopus 로고
    • The effects of grass pollen allergoid immunotherapy on clinical and immunological parameters in children with allergic rhinitis
    • Keskin O., Tuncer A., Adalioglu G., et al. The effects of grass pollen allergoid immunotherapy on clinical and immunological parameters in children with allergic rhinitis. Pediatr Allergy Immunol 2006, 17(6):396-407.
    • (2006) Pediatr Allergy Immunol , vol.17 , Issue.6 , pp. 396-407
    • Keskin, O.1    Tuncer, A.2    Adalioglu, G.3
  • 108
    • 67349111290 scopus 로고    scopus 로고
    • Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy
    • e1101-4
    • Di Lorenzo G., Mansueto P., Pacor M.L., et al. Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy. J Allergy Clin Immunol 2009, 123(5):1103-1110. e1101-4.
    • (2009) J Allergy Clin Immunol , vol.123 , Issue.5 , pp. 1103-1110
    • Di Lorenzo, G.1    Mansueto, P.2    Pacor, M.L.3
  • 109
    • 53749096798 scopus 로고    scopus 로고
    • Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors
    • Meiler F., Klunker S., Zimmermann M., et al. Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors. Allergy 2008, 63(11):1455-1463.
    • (2008) Allergy , vol.63 , Issue.11 , pp. 1455-1463
    • Meiler, F.1    Klunker, S.2    Zimmermann, M.3
  • 110
    • 77949355609 scopus 로고    scopus 로고
    • Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy
    • Dugas-Breit S., Przybilla B., Dugas M., et al. Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy. Clin Exp Allergy 2010, 40(4):643-649.
    • (2010) Clin Exp Allergy , vol.40 , Issue.4 , pp. 643-649
    • Dugas-Breit, S.1    Przybilla, B.2    Dugas, M.3
  • 111
    • 55349084351 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction
    • Gri G., Piconese S., Frossi B., et al. CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008, 29(5):771-781.
    • (2008) Immunity , vol.29 , Issue.5 , pp. 771-781
    • Gri, G.1    Piconese, S.2    Frossi, B.3
  • 112
    • 0030003889 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma
    • Durham S.R., Ying S., Varney V.A., et al. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. J Allergy Clin Immunol 1996, 97(6):1356-1365.
    • (1996) J Allergy Clin Immunol , vol.97 , Issue.6 , pp. 1356-1365
    • Durham, S.R.1    Ying, S.2    Varney, V.A.3
  • 113
    • 0035725164 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium
    • Wilson D.R., Irani A.M., Walker S.M., et al. Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium. Clin Exp Allergy 2001, 31(11):1705-1713.
    • (2001) Clin Exp Allergy , vol.31 , Issue.11 , pp. 1705-1713
    • Wilson, D.R.1    Irani, A.M.2    Walker, S.M.3
  • 114
    • 47649133312 scopus 로고    scopus 로고
    • A double-blind placebo-controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation
    • Wurtzen P.A., Lund G., Lund K., et al. A double-blind placebo-controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation. Clin Exp Allergy 2008, 38(8):1290-1301.
    • (2008) Clin Exp Allergy , vol.38 , Issue.8 , pp. 1290-1301
    • Wurtzen, P.A.1    Lund, G.2    Lund, K.3
  • 115
    • 21344441958 scopus 로고    scopus 로고
    • IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: effect of immunotherapy
    • Nouri-Aria K.T., Pilette C., Jacobson M.R., et al. IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: effect of immunotherapy. J Allergy Clin Immunol 2005, 116(1):73-79.
    • (2005) J Allergy Clin Immunol , vol.116 , Issue.1 , pp. 73-79
    • Nouri-Aria, K.T.1    Pilette, C.2    Jacobson, M.R.3
  • 116
    • 0035016912 scopus 로고    scopus 로고
    • Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season
    • Wilson D.R., Nouri-Aria K.T., Walker S.M., et al. Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season. J Allergy Clin Immunol 2001, 107(6):971-976.
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.6 , pp. 971-976
    • Wilson, D.R.1    Nouri-Aria, K.T.2    Walker, S.M.3
  • 117
    • 0028181890 scopus 로고
    • B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10
    • Schandene L., Alonso-Vega C., Willems F., et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J Immunol 1994, 152(9):4368-4374.
    • (1994) J Immunol , vol.152 , Issue.9 , pp. 4368-4374
    • Schandene, L.1    Alonso-Vega, C.2    Willems, F.3
  • 118
    • 0025202681 scopus 로고
    • Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season
    • Rak S., Hakanson L., Venge P. Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season. J Allergy Clin Immunol 1990, 86(5):706-713.
    • (1990) J Allergy Clin Immunol , vol.86 , Issue.5 , pp. 706-713
    • Rak, S.1    Hakanson, L.2    Venge, P.3
  • 119
    • 54449096147 scopus 로고    scopus 로고
    • A follow-up study of immunotherapy-treated birch-allergic patients: effect on the expression of chemokines in the nasal mucosa
    • Plewako H., Holmberg K., Oancea I., et al. A follow-up study of immunotherapy-treated birch-allergic patients: effect on the expression of chemokines in the nasal mucosa. Clin Exp Allergy 2008, 38(7):1124-1131.
    • (2008) Clin Exp Allergy , vol.38 , Issue.7 , pp. 1124-1131
    • Plewako, H.1    Holmberg, K.2    Oancea, I.3
  • 120
    • 77954342517 scopus 로고    scopus 로고
    • Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells
    • Zhao C.Q., Li T.L., He S.H., et al. Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells. Allergy 2010, 65(8):986-995.
    • (2010) Allergy , vol.65 , Issue.8 , pp. 986-995
    • Zhao, C.Q.1    Li, T.L.2    He, S.H.3
  • 121
    • 0023722274 scopus 로고
    • The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients
    • Rak S., Lowhagen O., Venge P. The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. J Allergy Clin Immunol 1988, 82(3 Pt 1):470-480.
    • (1988) J Allergy Clin Immunol , vol.82 , Issue.3 PART 1 , pp. 470-480
    • Rak, S.1    Lowhagen, O.2    Venge, P.3
  • 122
    • 22744457505 scopus 로고    scopus 로고
    • CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses
    • Wing K., Larsson P., Sandstrom K., et al. CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses. Immunology 2005, 115(4):516-525.
    • (2005) Immunology , vol.115 , Issue.4 , pp. 516-525
    • Wing, K.1    Larsson, P.2    Sandstrom, K.3
  • 123
    • 0034327264 scopus 로고    scopus 로고
    • T regulatory cells 1 inhibit a Th2-specific response in vivo
    • Cottrez F., Hurst S.D., Coffman R.L., et al. T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 2000, 165(9):4848-4853.
    • (2000) J Immunol , vol.165 , Issue.9 , pp. 4848-4853
    • Cottrez, F.1    Hurst, S.D.2    Coffman, R.L.3
  • 124
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis
    • Chen Y., Kuchroo V.K., Inobe J., et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265(5176):1237-1240.
    • (1994) Science , vol.265 , Issue.5176 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3
  • 125
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • Clark R.A., Huang S.J., Murphy G.F., et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 2008, 205(10):2221-2234.
    • (2008) J Exp Med , vol.205 , Issue.10 , pp. 2221-2234
    • Clark, R.A.1    Huang, S.J.2    Murphy, G.F.3
  • 126
    • 28544432829 scopus 로고    scopus 로고
    • CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    • Lewkowich I.P., Herman N.S., Schleifer K.W., et al. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. J Exp Med 2005, 202(11):1549-1561.
    • (2005) J Exp Med , vol.202 , Issue.11 , pp. 1549-1561
    • Lewkowich, I.P.1    Herman, N.S.2    Schleifer, K.W.3
  • 127
    • 33845445488 scopus 로고    scopus 로고
    • Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-beta for their induction
    • Bellinghausen I., Konig B., Bottcher I., et al. Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-beta for their induction. Clin Exp Allergy 2006, 36(12):1546-1555.
    • (2006) Clin Exp Allergy , vol.36 , Issue.12 , pp. 1546-1555
    • Bellinghausen, I.1    Konig, B.2    Bottcher, I.3
  • 128
    • 73249122393 scopus 로고    scopus 로고
    • Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways
    • Jaffar Z., Ferrini M.E., Girtsman T.A., et al. Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways. Eur J Immunol 2009, 39(12):3307-3314.
    • (2009) Eur J Immunol , vol.39 , Issue.12 , pp. 3307-3314
    • Jaffar, Z.1    Ferrini, M.E.2    Girtsman, T.A.3
  • 129
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis
    • Kitani A., Fuss I., Nakamura K., et al. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med 2003, 198(8):1179-1188.
    • (2003) J Exp Med , vol.198 , Issue.8 , pp. 1179-1188
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3
  • 130
    • 0036169602 scopus 로고    scopus 로고
    • T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
    • Trautmann A., Schmid-Grendelmeier P., Kruger K., et al. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma. J Allergy Clin Immunol 2002, 109(2):329-337.
    • (2002) J Allergy Clin Immunol , vol.109 , Issue.2 , pp. 329-337
    • Trautmann, A.1    Schmid-Grendelmeier, P.2    Kruger, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.