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Volumn 123, Issue 3, 2009, Pages

Differentiation and functional analysis of human TH17 cells

Author keywords

airway inflammation; differentiation; IL 17; primary bronchial epithelial cells; regulatory T cells; TGF ; transcription factor

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RORC2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 61549130932     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.12.017     Document Type: Article
Times cited : (100)

References (38)
  • 2
    • 0037338904 scopus 로고    scopus 로고
    • The role of T lymphocytes in the pathogenesis of asthma
    • Larché M., Robinson D.S., and Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111 (2003) 450-463
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 450-463
    • Larché, M.1    Robinson, D.S.2    Kay, A.B.3
  • 3
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov II1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 4
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28 (2008) 29-39
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 5
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 6
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato K., Suematsu A., Okamoto K., Yamaguchi A., Morishita Y., Kadono Y., et al. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203 (2006) 2673-2682
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3    Yamaguchi, A.4    Morishita, Y.5    Kadono, Y.6
  • 7
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C.H.G., Pedotti R., Brendolan A., Schadt E., Garren H., Langer-Gould A., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. J Biol Chem 8 (2002) 500-508
    • (2002) J Biol Chem , vol.8 , pp. 500-508
    • Lock, C.H.G.1    Pedotti, R.2    Brendolan, A.3    Schadt, E.4    Garren, H.5    Langer-Gould, A.6
  • 8
    • 0033772374 scopus 로고    scopus 로고
    • Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus
    • Wong C.K., Ho C.Y., Li E.K., and Lam C.W. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9 (2000) 589-593
    • (2000) Lupus , vol.9 , pp. 589-593
    • Wong, C.K.1    Ho, C.Y.2    Li, E.K.3    Lam, C.W.4
  • 9
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D., Cheung J., Scheerens H., Poulet F., McClanahan T., McKenzie B., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 (2006) 1310-1316
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3    Poulet, F.4    McClanahan, T.5    McKenzie, B.6
  • 10
    • 20844455261 scopus 로고    scopus 로고
    • Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects
    • Hashimoto T., Akiyama K., Kobayashi N., and Mori A. Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int Arch Allergy Immunol 137 suppl 1 (2005) 51-54
    • (2005) Int Arch Allergy Immunol , vol.137 , Issue.SUPPL. 1 , pp. 51-54
    • Hashimoto, T.1    Akiyama, K.2    Kobayashi, N.3    Mori, A.4
  • 11
    • 0034833339 scopus 로고    scopus 로고
    • IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    • Molet S., Hamid Q., Davoine F., Nutku E., Taha R., Page N., et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108 (2001) 430-438
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 430-438
    • Molet, S.1    Hamid, Q.2    Davoine, F.3    Nutku, E.4    Taha, R.5    Page, N.6
  • 12
    • 33745479516 scopus 로고    scopus 로고
    • Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients
    • Matsunaga K., Yanagisawa S., Ichikawa T., Ueshima K., Akamatsu K., Hirano T., et al. Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol 118 (2006) 84-90
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 84-90
    • Matsunaga, K.1    Yanagisawa, S.2    Ichikawa, T.3    Ueshima, K.4    Akamatsu, K.5    Hirano, T.6
  • 13
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 15
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 16
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., and Gurney A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278 (2003) 1910-1914
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 18
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198 (2003) 1875-1886
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 19
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., and Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172 (2004) 5149-5153
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 20
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10
    • Zheng S.G., Wang J.H., Gray J.D., Soucier H., and Horwitz D.A. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 172 (2004) 5213-5221
    • (2004) J Immunol , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 21
    • 38549166301 scopus 로고    scopus 로고
    • GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    • Mantel P.Y., Kuipers H., Boyman O., Rhyner C., Ouaked N., Ruckert B., et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol 5 (2007) e329
    • (2007) PLoS Biol , vol.5
    • Mantel, P.Y.1    Kuipers, H.2    Boyman, O.3    Rhyner, C.4    Ouaked, N.5    Ruckert, B.6
  • 22
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel N., Unutmaz D., and Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9 (2008) 641-649
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 23
    • 44049102724 scopus 로고    scopus 로고
    • Critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe E., Servant N., Zollinger R., Bogiatzi S.I., Hupe P., Barillot E., et al. Critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9 (2008) 650-657
    • (2008) Nat Immunol , vol.9 , pp. 650-657
    • Volpe, E.1    Servant, N.2    Zollinger, R.3    Bogiatzi, S.I.4    Hupe, P.5    Barillot, E.6
  • 24
    • 0034882184 scopus 로고    scopus 로고
    • Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma
    • Wong C.K., Ho C.Y., Ko F.W., Chan C.H., Ho A.S., Hui D.S., et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 125 (2001) 177-183
    • (2001) Clin Exp Immunol , vol.125 , pp. 177-183
    • Wong, C.K.1    Ho, C.Y.2    Ko, F.W.3    Chan, C.H.4    Ho, A.S.5    Hui, D.S.6
  • 25
    • 0035761425 scopus 로고    scopus 로고
    • Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice
    • Forlow S.B., Schnurr J.R., Kolls J.K., Bagby G.J., Schwarzenberger P.O., and Ley K. Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood 98 (2001) 3309-3314
    • (2001) Blood , vol.98 , pp. 3309-3314
    • Forlow, S.B.1    Schnurr, J.R.2    Kolls, J.K.3    Bagby, G.J.4    Schwarzenberger, P.O.5    Ley, K.6
  • 26
    • 34147126728 scopus 로고    scopus 로고
    • An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
    • Yu J.J., Ruddy M.J., Wong G.C., Sfintescu C., Baker P.J., Smith J.B., et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 109 (2007) 3794-3802
    • (2007) Blood , vol.109 , pp. 3794-3802
    • Yu, J.J.1    Ruddy, M.J.2    Wong, G.C.3    Sfintescu, C.4    Baker, P.J.5    Smith, J.B.6
  • 28
    • 34547769911 scopus 로고    scopus 로고
    • Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6
    • Liu S.J., Tsai J.P., Shen C.R., Sher Y.P., Hsieh C.L., Yeh Y.C., et al. Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol 82 (2007) 354-360
    • (2007) J Leukoc Biol , vol.82 , pp. 354-360
    • Liu, S.J.1    Tsai, J.P.2    Shen, C.R.3    Sher, Y.P.4    Hsieh, C.L.5    Yeh, Y.C.6
  • 29
    • 0032442795 scopus 로고    scopus 로고
    • Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway
    • Shin H.C., Benbernou N., Fekkar H., Esnault S., and Guenounou M. Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine 10 (1998) 841-850
    • (1998) Cytokine , vol.10 , pp. 841-850
    • Shin, H.C.1    Benbernou, N.2    Fekkar, H.3    Esnault, S.4    Guenounou, M.5
  • 30
    • 39549106479 scopus 로고    scopus 로고
    • Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    • Pichavant M., Goya S., Meyer E.H., Johnston R.A., Kim H.Y., Matangkasombut P., et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 205 (2008) 385-393
    • (2008) J Exp Med , vol.205 , pp. 385-393
    • Pichavant, M.1    Goya, S.2    Meyer, E.H.3    Johnston, R.A.4    Kim, H.Y.5    Matangkasombut, P.6
  • 31
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L., Lopes J.E., Chong M.M., Ivanov I.I., Min R., Victora G.D., et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453 (2008) 236-240
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3    Ivanov, I.I.4    Min, R.5    Victora, G.D.6
  • 32
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits RORgamma t-mediated IL-17A mRNA transcription through direct interaction with RORgamma t
    • Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., et al. Foxp3 inhibits RORgamma t-mediated IL-17A mRNA transcription through direct interaction with RORgamma t. J Biol Chem 283 (2008) 17003-17008
    • (2008) J Biol Chem , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3    Chinen, T.4    Saeki, K.5    Nakaya, M.6
  • 34
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007) 480-483
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 35
    • 36749081557 scopus 로고    scopus 로고
    • Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
    • Evans H.G., Suddason T., Jackson I., Taams L.S., and Lord G.M. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A 104 (2007) 17034-17039
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17034-17039
    • Evans, H.G.1    Suddason, T.2    Jackson, I.3    Taams, L.S.4    Lord, G.M.5
  • 36
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 37
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 38
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6


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