Antigen-specific Treg regulate Th17-mediated lung neutrophilic inflammation, B-cell recruitment and polymeric IgA and IgM levels in the airways

European Journal of Immunology

Volumn 39, Issue 12, 2009, Pages 3307-3314

  Jaffar, Zeina ^a   Ferrini, Maria E ^a   Girtsman, Teri A ^a   Roberts, Kevan ^a  

^a UNIVERSITY OF MONTANA   (United States)

Author keywords

B cells; Lung inflammation; Regulation; Th17 cells; Treg

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BRONCHUS HYPERREACTIVITY; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOREGULATION; MEDIASTINUM LYMPH NODE; MOUSE; MUCOSAL IMMUNITY; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; TH17 CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS; B-LYMPHOCYTES; BRONCHIAL HYPERREACTIVITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERFERON-GAMMA; INTERLEUKIN-17; LUNG; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEUTROPHILS; OVALBUMIN; PNEUMONIA; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 73249122393     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939498     Document Type: Article

References (17)

1. Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M. and Weaver, C. T., Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005. 6: 1123-1132.
2. Korn, T., Bettelli, E., Oukka, M. and Kuchroo, V. K., IL-17 and Th17 Cells. Annu. Rev. Immunol. 2009. 27: 485-517.
3. Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235-238.
4. Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., Distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 1133-1141.
5. Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., Comeau, M. R., Cohen, J. I. and Spriggs, M. K., Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995. 3: 811-821.
6. Ye, P., Rodriguez, F. H., Kanaly, S., Stocking, K. L., Schurr, J., Schwarzenberger, P., Oliver, P. et al., Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 2001. 194: 519-527.
7. Liang, S. C., Tan, X. Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M. and Fouser, L. A., Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 2006. 203: 2271-2279.
8. Shevach, E. M., DiPaolo, R. A., Andersson, J., Zhao, D. M., Stephens, G. L. and Thornton, A. M., The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells. Immunol. Rev. 2006. 212: 60-73.
9. Sakaguchi, S., Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004. 22: 531-562.
10. Horwitz, D. A., Zheng, S. G. and Gray, J. D., Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008. 29: 429-435.
11. Zheng, S. G., Wang, J. and Horwitz, D. A., Cutting edge: Foxp3+CD4+ CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 2008. 180: 7112-7116.
12. Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M. et al., IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 2008. 9: 1347-1355.
13. Jaffar, Z., Ferrini, M. E., Herritt, L. A. and Roberts, K., Cutting edge: lung mucosal Th17-mediated responses induce polymeric Ig receptor expression by the airway epithelium and elevate secretory IgA levels. J. Immunol. 2009. 182: 4507-4511.
14. Bopp, T., Dehzad, N., Reuter, S., Klein, M., Ullrich, N., Stassen, M., Schild, H. et al., Inhibition of cAMP degradation improves regulatory T cell-mediated suppression. J. Immunol. 2009. 182: 4017-4024.
15. Huter, E. N., Stummvoll, G. H., DiPaolo, R. J., Glass, D. D. and Shevach, E. M., Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J. Immunol. 2008. 181: 8209-8213.
16. Jaffar, Z., Wan, K. S. and Roberts, K., A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen. J. Immunol. 2002. 169: 5997-6004.
17. Jaffar, Z., Sivakuru, T. and Roberts, K., CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype. J. Immunol. 2004. 172: 3842-3849.