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Volumn 10, Issue 7, 2011, Pages 375-382

Factors implicated in the generation and persistence of long-lived plasma cell-mediated autoimmunity

Author keywords

Long lived plasma cells; Survival niches; Therapeutic targets

Indexed keywords

AUTOANTIBODY;

EID: 79955094058     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2010.12.007     Document Type: Review
Times cited : (16)

References (105)
  • 1
    • 56749098376 scopus 로고    scopus 로고
    • How to cope with pathogenic long-lived plasma cells in autoimmune diseases
    • Hoyer B.F., Mumtaz I.M., Yoshida T., Hiepe F., Radbruch A. How to cope with pathogenic long-lived plasma cells in autoimmune diseases. Ann Rheum Dis 2008, 67:iii87-iii89.
    • (2008) Ann Rheum Dis , vol.67
    • Hoyer, B.F.1    Mumtaz, I.M.2    Yoshida, T.3    Hiepe, F.4    Radbruch, A.5
  • 3
    • 2942692040 scopus 로고    scopus 로고
    • Targeting plasma cells in autoimmune diseases
    • Tarlinton D.M., Hodgkin P.D. Targeting plasma cells in autoimmune diseases. J Exp Med 2004, 199:1451-1454.
    • (2004) J Exp Med , vol.199 , pp. 1451-1454
    • Tarlinton, D.M.1    Hodgkin, P.D.2
  • 5
    • 39649084660 scopus 로고    scopus 로고
    • Plasma cell development: from B-cell subsets to long-term survival niches
    • Fairfax K.A., Kallies A., Nutt S.L., Tarlinton D.M. Plasma cell development: from B-cell subsets to long-term survival niches. Semin Immunol 2008, 20:49-58.
    • (2008) Semin Immunol , vol.20 , pp. 49-58
    • Fairfax, K.A.1    Kallies, A.2    Nutt, S.L.3    Tarlinton, D.M.4
  • 6
    • 33745662565 scopus 로고    scopus 로고
    • B cells move to centre stage: novel opportunities for autoimmune disease treatment
    • Browning J.L. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nature 2006, 5:564-576.
    • (2006) Nature , vol.5 , pp. 564-576
    • Browning, J.L.1
  • 8
    • 33746503135 scopus 로고    scopus 로고
    • Role of B-1a cells in autoimmunity
    • Duan B., Morel L. Role of B-1a cells in autoimmunity. Autoimmun Rev 2006, 6:403-408.
    • (2006) Autoimmun Rev , vol.6 , pp. 403-408
    • Duan, B.1    Morel, L.2
  • 10
    • 33947644970 scopus 로고    scopus 로고
    • Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene
    • Fairfax K., Corcoran L.M., Pridans C., Huntington N.D., Kallies A., Nutt S.L., et al. Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene. J Immunol 2007, 178:4104-4111.
    • (2007) J Immunol , vol.178 , pp. 4104-4111
    • Fairfax, K.1    Corcoran, L.M.2    Pridans, C.3    Huntington, N.D.4    Kallies, A.5    Nutt, S.L.6
  • 11
    • 17144418984 scopus 로고    scopus 로고
    • Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
    • Gatto D., Pfister T., Jegerlehner A., Martin S.W., Kopf M., Bachmann M.F. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med 2005, 201:993-1005.
    • (2005) J Exp Med , vol.201 , pp. 993-1005
    • Gatto, D.1    Pfister, T.2    Jegerlehner, A.3    Martin, S.W.4    Kopf, M.5    Bachmann, M.F.6
  • 12
    • 0242663862 scopus 로고    scopus 로고
    • Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis
    • Mongini P.K.A., Jackson A.E., Tolani S., Fattah R.J., Inman JK J.K. Role of complement-binding CD21/CD19/CD81 in enhancing human B cell protection from Fas-mediated apoptosis. J Immunol 2003, 171:5244-5254.
    • (2003) J Immunol , vol.171 , pp. 5244-5254
    • Mongini, P.K.A.1    Jackson, A.E.2    Tolani, S.3    Fattah, R.J.4    Inman, J.K.J.K.5
  • 13
  • 14
    • 73949120281 scopus 로고    scopus 로고
    • VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy
    • Arons E., Suntum T., Stetler-Stevenson M., Kreitman R.J. VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy. Blood 2009, 114:4687-4695.
    • (2009) Blood , vol.114 , pp. 4687-4695
    • Arons, E.1    Suntum, T.2    Stetler-Stevenson, M.3    Kreitman, R.J.4
  • 15
    • 0026611386 scopus 로고
    • VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities
    • Pascual V., Victor K., Spellerberg M., Hamblin T.J., Stevenson F.K., Capra J.D. VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992, 149:2337-2344.
    • (1992) J Immunol , vol.149 , pp. 2337-2344
    • Pascual, V.1    Victor, K.2    Spellerberg, M.3    Hamblin, T.J.4    Stevenson, F.K.5    Capra, J.D.6
  • 16
    • 0035796411 scopus 로고    scopus 로고
    • A coordinated change in chemokine responsiveness guides plasma cell movements
    • Hargreaves D.C., Hyman P.L., Lu T.T., Ngo V.N., Bidgol A., Suzuki G., et al. A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med 2001, 194:45-56.
    • (2001) J Exp Med , vol.194 , pp. 45-56
    • Hargreaves, D.C.1    Hyman, P.L.2    Lu, T.T.3    Ngo, V.N.4    Bidgol, A.5    Suzuki, G.6
  • 17
    • 20844450563 scopus 로고    scopus 로고
    • Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells
    • Muehlinghaus G., Cigliano L., Huehn S., Peddinghaus A., Leyendeckers H., Hauser A.E., et al. Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 2005, 105:3965-3971.
    • (2005) Blood , vol.105 , pp. 3965-3971
    • Muehlinghaus, G.1    Cigliano, L.2    Huehn, S.3    Peddinghaus, A.4    Leyendeckers, H.5    Hauser, A.E.6
  • 18
    • 70249099586 scopus 로고    scopus 로고
    • Organization and maintenance of immunological memory by stroma niches
    • Tokoyoda K., Zehentmeier S., Chang H., Radbruch A. Organization and maintenance of immunological memory by stroma niches. Eur J Immunol 2009, 39:2095-2099.
    • (2009) Eur J Immunol , vol.39 , pp. 2095-2099
    • Tokoyoda, K.1    Zehentmeier, S.2    Chang, H.3    Radbruch, A.4
  • 19
    • 14944362858 scopus 로고    scopus 로고
    • Regulation of plasma-cell development
    • Shapiro-Shelef M., Calame K. Regulation of plasma-cell development. Nature 2005, 5:230-242.
    • (2005) Nature , vol.5 , pp. 230-242
    • Shapiro-Shelef, M.1    Calame, K.2
  • 20
    • 33751253159 scopus 로고    scopus 로고
    • VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF
    • Schaumann D.H.S., Tuischer J., Ebell W., Manz R.A., Lauster R. VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF. Mol Immunol 2007, 44:1606-1612.
    • (2007) Mol Immunol , vol.44 , pp. 1606-1612
    • Schaumann, D.H.S.1    Tuischer, J.2    Ebell, W.3    Manz, R.A.4    Lauster, R.5
  • 21
    • 20844432040 scopus 로고    scopus 로고
    • Identification of proteoglycans as the APRIL-specific binding partners
    • Ingold K., Zumsteg A., Tardivel A., Huard B., Steiner Q., Cachero T.G., et al. Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med 2005, 201:1375-1383.
    • (2005) J Exp Med , vol.201 , pp. 1375-1383
    • Ingold, K.1    Zumsteg, A.2    Tardivel, A.3    Huard, B.4    Steiner, Q.5    Cachero, T.G.6
  • 22
    • 0042591464 scopus 로고    scopus 로고
    • Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
    • Cassesse G., Arce S., Hauser A.E., Lehnert K., Moewes B., Mostarac M., et al. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol 2003, 171:1684-1690.
    • (2003) J Immunol , vol.171 , pp. 1684-1690
    • Cassesse, G.1    Arce, S.2    Hauser, A.E.3    Lehnert, K.4    Moewes, B.5    Mostarac, M.6
  • 23
    • 36148944492 scopus 로고    scopus 로고
    • B cells in SLE: different biologic drugs for different pathogenic mechanisms
    • Diamanti A.P., Rosado M.M., Carsetti R., Valesini G. B cells in SLE: different biologic drugs for different pathogenic mechanisms. Autoimmun Rev 2007, 7:143-148.
    • (2007) Autoimmun Rev , vol.7 , pp. 143-148
    • Diamanti, A.P.1    Rosado, M.M.2    Carsetti, R.3    Valesini, G.4
  • 24
    • 40449117122 scopus 로고    scopus 로고
    • CD22 regulates time course of both B cell division and antibody response
    • Onodera T., Poe J.C., Tedder T.F., Tsubata T. CD22 regulates time course of both B cell division and antibody response. J Immunol 2008, 180:907-913.
    • (2008) J Immunol , vol.180 , pp. 907-913
    • Onodera, T.1    Poe, J.C.2    Tedder, T.F.3    Tsubata, T.4
  • 25
    • 0033519233 scopus 로고    scopus 로고
    • Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B Cells
    • Nitschke L., Flyd H., Ferguson D.J.P., Crocker P.R. Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B Cells. J Exp Med 1999, 189:1513-1518.
    • (1999) J Exp Med , vol.189 , pp. 1513-1518
    • Nitschke, L.1    Flyd, H.2    Ferguson, D.J.P.3    Crocker, P.R.4
  • 26
    • 34248543774 scopus 로고    scopus 로고
    • Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
    • Kallies A., Hasbold J., Fairfax K., Pridans C., Emslie D., McKenzie B.S., et al. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 2007, 26:555-566.
    • (2007) Immunity , vol.26 , pp. 555-566
    • Kallies, A.1    Hasbold, J.2    Fairfax, K.3    Pridans, C.4    Emslie, D.5    McKenzie, B.S.6
  • 27
    • 5344280456 scopus 로고    scopus 로고
    • MTA3 and the Mi/NuRD complex regulate cell fate during B lymphocyte differentiation
    • Fujita N., Jaye D.L., Geigerman C., Akyildiz A., Mooney R., Boss J.M., et al. MTA3 and the Mi/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 2004, 119:75-86.
    • (2004) Cell , vol.119 , pp. 75-86
    • Fujita, N.1    Jaye, D.L.2    Geigerman, C.3    Akyildiz, A.4    Mooney, R.5    Boss, J.M.6
  • 28
    • 2142750272 scopus 로고    scopus 로고
    • Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation
    • Sciammas R., Davis M.M. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol 2004, 172:5427-5440.
    • (2004) J Immunol , vol.172 , pp. 5427-5440
    • Sciammas, R.1    Davis, M.M.2
  • 29
    • 18444395232 scopus 로고    scopus 로고
    • Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program
    • Shaffer A.L., Lin K., Kuo T.C., Yu X., Hurt E.M., Rosenwald A., et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002, 17:51-62.
    • (2002) Immunity , vol.17 , pp. 51-62
    • Shaffer, A.L.1    Lin, K.2    Kuo, T.C.3    Yu, X.4    Hurt, E.M.5    Rosenwald, A.6
  • 30
    • 37549012597 scopus 로고    scopus 로고
    • Induction of apoptosis in plasma cells by B lymphocyte-induced maturation Proein-1 knockdown
    • Lin F., Kuo H., Ying H., Yang F., Lin K. Induction of apoptosis in plasma cells by B lymphocyte-induced maturation Proein-1 knockdown. Cancer Res 2007, 67:1914-1923.
    • (2007) Cancer Res , vol.67 , pp. 1914-1923
    • Lin, F.1    Kuo, H.2    Ying, H.3    Yang, F.4    Lin, K.5
  • 31
    • 33947644970 scopus 로고    scopus 로고
    • Different kinetics of Blimp-1 induction in B cells subsets revealed by reporter gene
    • Fairfax K.A., Corcoran L.M., Pridans C., Huntington N.D., Kallies A., Nutt S.L., et al. Different kinetics of Blimp-1 induction in B cells subsets revealed by reporter gene. J Immunol 2007, 178:4104-4111.
    • (2007) J Immunol , vol.178 , pp. 4104-4111
    • Fairfax, K.A.1    Corcoran, L.M.2    Pridans, C.3    Huntington, N.D.4    Kallies, A.5    Nutt, S.L.6
  • 32
    • 28544444025 scopus 로고    scopus 로고
    • Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow
    • Shapiro-Shelef M., Lin K., Savitsky D., Liao J. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med 2005, 202:1471-1476.
    • (2005) J Exp Med , vol.202 , pp. 1471-1476
    • Shapiro-Shelef, M.1    Lin, K.2    Savitsky, D.3    Liao, J.4
  • 33
    • 0343340028 scopus 로고    scopus 로고
    • Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family
    • Knödel M., Kuss A.W., Lindemann D., Berberich I., Schimpl A. Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family. Eur J Immunol 1999, 29:2988-2998.
    • (1999) Eur J Immunol , vol.29 , pp. 2988-2998
    • Knödel, M.1    Kuss, A.W.2    Lindemann, D.3    Berberich, I.4    Schimpl, A.5
  • 34
    • 0031883536 scopus 로고    scopus 로고
    • Long-lived B cells are distinguished by elevated expression of A1
    • Tomayko M.M., Cancro M.P. Long-lived B cells are distinguished by elevated expression of A1. J Immunol 1998, 160:107-111.
    • (1998) J Immunol , vol.160 , pp. 107-111
    • Tomayko, M.M.1    Cancro, M.P.2
  • 35
    • 3142658576 scopus 로고    scopus 로고
    • XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    • Shaffer A.L., Shapiro-Shelef M., Iwakoshi N.N., Lee A., Qian S., Zhao H., et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 2004, 21:81-93.
    • (2004) Immunity , vol.21 , pp. 81-93
    • Shaffer, A.L.1    Shapiro-Shelef, M.2    Iwakoshi, N.N.3    Lee, A.4    Qian, S.5    Zhao, H.6
  • 36
    • 0037385313 scopus 로고    scopus 로고
    • Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    • Iwakoshi N.N., Lee A., Vallabhajosyula P., Otipoby K.L., Rajewsky K., Glimcher L.H. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nature 2003, 4:321-329.
    • (2003) Nature , vol.4 , pp. 321-329
    • Iwakoshi, N.N.1    Lee, A.2    Vallabhajosyula, P.3    Otipoby, K.L.4    Rajewsky, K.5    Glimcher, L.H.6
  • 37
    • 33749531054 scopus 로고    scopus 로고
    • Kinetics of human B cell behaviour and amplification of proliferative responses following stimulation with IL-21
    • Good K.L., Bryant V.L., Tangye S.G. Kinetics of human B cell behaviour and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006, 177:5236-5247.
    • (2006) J Immunol , vol.177 , pp. 5236-5247
    • Good, K.L.1    Bryant, V.L.2    Tangye, S.G.3
  • 38
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt K., Bulfone-Paus S., Foster D.C., Ruckert R. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 2003, 102:4090-4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Ruckert, R.4
  • 39
    • 38049110981 scopus 로고    scopus 로고
    • Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    • Kuchen S., Robbins R., Sims G.P., Sheng C., Phillips T.M., Lipsky P.E., et al. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol 2007, 179:5886-5896.
    • (2007) J Immunol , vol.179 , pp. 5886-5896
    • Kuchen, S.1    Robbins, R.2    Sims, G.P.3    Sheng, C.4    Phillips, T.M.5    Lipsky, P.E.6
  • 40
    • 61449255987 scopus 로고    scopus 로고
    • IL-21: an executor of B cell fate
    • Konforte D., Simard N., Paige C.J. IL-21: an executor of B cell fate. J Immunol 2009, 182:1781-1787.
    • (2009) J Immunol , vol.182 , pp. 1781-1787
    • Konforte, D.1    Simard, N.2    Paige, C.J.3
  • 41
  • 42
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    • Bryant V.L., Ma C.S., Avery D.T., Li Y., GoodL K.L., Corcoran L.M., et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 2007, 179:8180-8190.
    • (2007) J Immunol , vol.179 , pp. 8180-8190
    • Bryant, V.L.1    Ma, C.S.2    Avery, D.T.3    Li, Y.4    GoodL, K.L.5    Corcoran, L.M.6
  • 43
    • 33646463021 scopus 로고    scopus 로고
    • Induction of high Bcl6 expression and its roles in germinal center B cells
    • Arguni E., Tsuruoka N., Arima M., Sakamoto A., Hatano M., Tokuhisa T. Induction of high Bcl6 expression and its roles in germinal center B cells. Int Congr 2005, 1285:130-136.
    • (2005) Int Congr , vol.1285 , pp. 130-136
    • Arguni, E.1    Tsuruoka, N.2    Arima, M.3    Sakamoto, A.4    Hatano, M.5    Tokuhisa, T.6
  • 44
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman M.A., Beaton L., Yu D., Ramiscal R.R., Srivastava M., Hogan J.J., et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010, 207:353-363.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3    Ramiscal, R.R.4    Srivastava, M.5    Hogan, J.J.6
  • 45
    • 0036634390 scopus 로고    scopus 로고
    • BAFF: a fundamental survival factor for B cells
    • Mackay F., Browning J.L. BAFF: a fundamental survival factor for B cells. Nature 2002, 2:465-475.
    • (2002) Nature , vol.2 , pp. 465-475
    • Mackay, F.1    Browning, J.L.2
  • 47
    • 33847342813 scopus 로고    scopus 로고
    • IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    • Ettinger R., Sims G.P., Robbins R., Withers D., Fischer R.T., Grammer A.C., et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J Immunol 2007, 178:2872-2882.
    • (2007) J Immunol , vol.178 , pp. 2872-2882
    • Ettinger, R.1    Sims, G.P.2    Robbins, R.3    Withers, D.4    Fischer, R.T.5    Grammer, A.C.6
  • 48
    • 63749101171 scopus 로고    scopus 로고
    • Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance
    • Wang X.F., Yuan S.L., Jiang L., Zhang X.L., Li S.F., Guo Y., et al. Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance. Chin J Cell Mol Immunol 2007, 23:1041-1042.
    • (2007) Chin J Cell Mol Immunol , vol.23 , pp. 1041-1042
    • Wang, X.F.1    Yuan, S.L.2    Jiang, L.3    Zhang, X.L.4    Li, S.F.5    Guo, Y.6
  • 49
    • 29144519767 scopus 로고    scopus 로고
    • IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    • Ettinger R., Sims G.P., Fairhurst A.M., Robbins R., Silva Y.S., Spolski R., et al. IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol 2005, 176:7867-7879.
    • (2005) J Immunol , vol.176 , pp. 7867-7879
    • Ettinger, R.1    Sims, G.P.2    Fairhurst, A.M.3    Robbins, R.4    Silva, Y.S.5    Spolski, R.6
  • 50
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D., Brown T.P., Liang S., Young D.A., Collins M., Dunussi-Joannopoulus K. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J Immunol 2007, 178:3822-3830.
    • (2007) J Immunol , vol.178 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulus, K.6
  • 51
    • 35748930247 scopus 로고    scopus 로고
    • Treatment of BXSB-Yaa mice with IL-21R.Fc fusion protein minimally attenuates systemic lupus erythematosus
    • Bubier J.A., Bennett S.M., Sproule T.J., Lyons B.L., Olland S., Young D.A., et al. Treatment of BXSB-Yaa mice with IL-21R.Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann NY Acad Sci 2007, 1110:590-601.
    • (2007) Ann NY Acad Sci , vol.1110 , pp. 590-601
    • Bubier, J.A.1    Bennett, S.M.2    Sproule, T.J.3    Lyons, B.L.4    Olland, S.5    Young, D.A.6
  • 52
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signalling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier J.A., Sproule T.J., Foreman O., Spolski R., Shaffer D.J., Morse H.C., et al. A critical role for IL-21 receptor signalling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci USA 2009, 106:1518-1523.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3    Spolski, R.4    Shaffer, D.J.5    Morse, H.C.6
  • 53
    • 34247257447 scopus 로고    scopus 로고
    • Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    • Young D.A., Hegen M., Ma H.L., Whitters M.J., Albert L.M., Lowe L., et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007, 56:1152-1163.
    • (2007) Arthritis Rheum , vol.56 , pp. 1152-1163
    • Young, D.A.1    Hegen, M.2    Ma, H.L.3    Whitters, M.J.4    Albert, L.M.5    Lowe, L.6
  • 54
    • 2342491493 scopus 로고    scopus 로고
    • Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
    • Jungel A., Distler J.H.W., Kurowska-Stolarska M., Seemayer C.A., Seibl R., Forster A., et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum 2004, 50:1468-1476.
    • (2004) Arthritis Rheum , vol.50 , pp. 1468-1476
    • Jungel, A.1    Distler, J.H.W.2    Kurowska-Stolarska, M.3    Seemayer, C.A.4    Seibl, R.5    Forster, A.6
  • 55
    • 59849091674 scopus 로고    scopus 로고
    • Serum IL-21 level in patients with primary Sjögren's syndrome and clinical significance of IL-21
    • Yuan S.L., Jiang L., Zhang X.L., Li S.F., Duan H.M., Wang X.F. Serum IL-21 level in patients with primary Sjögren's syndrome and clinical significance of IL-21. Chin J Cell Mol Immunol 2007, 23:124-126.
    • (2007) Chin J Cell Mol Immunol , vol.23 , pp. 124-126
    • Yuan, S.L.1    Jiang, L.2    Zhang, X.L.3    Li, S.F.4    Duan, H.M.5    Wang, X.F.6
  • 56
    • 58149279490 scopus 로고    scopus 로고
    • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    • Odegard J.M., Marks B.R., DiPlacido L.D., Poholek A.C., Kono D.H., Dong C., et al. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J Exp Med 2008, 205:2873-2886.
    • (2008) J Exp Med , vol.205 , pp. 2873-2886
    • Odegard, J.M.1    Marks, B.R.2    DiPlacido, L.D.3    Poholek, A.C.4    Kono, D.H.5    Dong, C.6
  • 57
    • 0041331737 scopus 로고    scopus 로고
    • Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis
    • Iwai H., Abe M., Hirose S., Tsushima F., Tezuka K., Akiba H., et al. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 2003, 171:2848-2854.
    • (2003) J Immunol , vol.171 , pp. 2848-2854
    • Iwai, H.1    Abe, M.2    Hirose, S.3    Tsushima, F.4    Tezuka, K.5    Akiba, H.6
  • 58
    • 5644273872 scopus 로고    scopus 로고
    • Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus
    • Hutloff A., Bϋchner K., Reiter K., Baelde H.J., Odendahl M., Jacobi A., et al. Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum 2004, 50:3211-3220.
    • (2004) Arthritis Rheum , vol.50 , pp. 3211-3220
    • Hutloff, A.1    Bϋchner, K.2    Reiter, K.3    Baelde, H.J.4    Odendahl, M.5    Jacobi, A.6
  • 59
    • 1642500083 scopus 로고    scopus 로고
    • Aiolos Is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity
    • Cortés M., Georgopoulos K. Aiolos Is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. J Exp Med 2004, 199:209-219.
    • (2004) J Exp Med , vol.199 , pp. 209-219
    • Cortés, M.1    Georgopoulos, K.2
  • 60
    • 3342877696 scopus 로고    scopus 로고
    • BLyS - an essential survival factor for B cells: basic biology, links to pathology and therapeutic target
    • Baker K.P. BLyS - an essential survival factor for B cells: basic biology, links to pathology and therapeutic target. Autoimmun Rev 2004, 3:368-375.
    • (2004) Autoimmun Rev , vol.3 , pp. 368-375
    • Baker, K.P.1
  • 61
    • 18844447818 scopus 로고    scopus 로고
    • The role of APRIL and BAFF in lymphocyte activation
    • Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol 2005, 17:282-289.
    • (2005) Curr Opin Immunol , vol.17 , pp. 282-289
    • Schneider, P.1
  • 62
    • 33750341510 scopus 로고    scopus 로고
    • The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity
    • Cancro M.P. The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity. Ann Rheum Dis 2006, 65:34-36.
    • (2006) Ann Rheum Dis , vol.65 , pp. 34-36
    • Cancro, M.P.1
  • 64
    • 85047690330 scopus 로고    scopus 로고
    • BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    • Avery D.T., Kalled S.L., Ellyard J.I., Ambrose C., Bixler S.A., Thien M., et al. BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. J Clin Invest 2003, 112:286-297.
    • (2003) J Clin Invest , vol.112 , pp. 286-297
    • Avery, D.T.1    Kalled, S.L.2    Ellyard, J.I.3    Ambrose, C.4    Bixler, S.A.5    Thien, M.6
  • 65
    • 66449126945 scopus 로고    scopus 로고
    • The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
    • Cancro M.P., Cruz D.P., Khamashta A. The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest 2009, 119:1066-1073.
    • (2009) J Clin Invest , vol.119 , pp. 1066-1073
    • Cancro, M.P.1    Cruz, D.P.2    Khamashta, A.3
  • 66
    • 41949138741 scopus 로고    scopus 로고
    • APRIL is critical for plasmablast survival in bone marrow and poorly expressed in early-life bone marrow stromal cells
    • Belnoue E., Pihlgren M., McGaha T.L., Tougne C., Rochat A., Bossen C., et al. APRIL is critical for plasmablast survival in bone marrow and poorly expressed in early-life bone marrow stromal cells. Blood 2008, 111:2755-2764.
    • (2008) Blood , vol.111 , pp. 2755-2764
    • Belnoue, E.1    Pihlgren, M.2    McGaha, T.L.3    Tougne, C.4    Rochat, A.5    Bossen, C.6
  • 68
    • 55749115444 scopus 로고    scopus 로고
    • BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
    • Scholz J.L., Crowley J.E., Tomayko M.M., Steinel N., O'Neill P.J., Quinn W.J., et al. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc Natl Acad Sci USA 2008, 105:15517-15522.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15517-15522
    • Scholz, J.L.1    Crowley, J.E.2    Tomayko, M.M.3    Steinel, N.4    O'Neill, P.J.5    Quinn, W.J.6
  • 69
    • 70350517490 scopus 로고    scopus 로고
    • Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
    • Vallerskog T., Heimbϋrger M., Gunnarsson I., Zhou W., Wahren-Herlenius M., Trollmo C., et al. Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther 2006, 8:R167.
    • (2006) Arthritis Res Ther , vol.8
    • Vallerskog, T.1    Heimbϋrger, M.2    Gunnarsson, I.3    Zhou, W.4    Wahren-Herlenius, M.5    Trollmo, C.6
  • 70
    • 49449092839 scopus 로고    scopus 로고
    • Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    • Petri M., Stohl W., Chatham W., McCune W.J., Chevrier M., Ryel J., et al. Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus. Arthritis Rheum 2008, 58:2453-2459.
    • (2008) Arthritis Rheum , vol.58 , pp. 2453-2459
    • Petri, M.1    Stohl, W.2    Chatham, W.3    McCune, W.J.4    Chevrier, M.5    Ryel, J.6
  • 71
    • 78649314600 scopus 로고    scopus 로고
    • Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients
    • Zhao L.D., Li Y., Smith M.F., Wang J.S., Zhang W., Tang F.L., et al. Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients. Lupus 2010, 19:1534-1549.
    • (2010) Lupus , vol.19 , pp. 1534-1549
    • Zhao, L.D.1    Li, Y.2    Smith, M.F.3    Wang, J.S.4    Zhang, W.5    Tang, F.L.6
  • 72
    • 70350520105 scopus 로고    scopus 로고
    • B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
    • Collins C.E., Gavin A.L., Migone T., Hilbert D.M., Nemazee D., Stohl W. B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. Arthritis Res Ther 2006, 8:R6.
    • (2006) Arthritis Res Ther , vol.8
    • Collins, C.E.1    Gavin, A.L.2    Migone, T.3    Hilbert, D.M.4    Nemazee, D.5    Stohl, W.6
  • 73
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema G.S., Roschke V., Hilbert D.M., Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum 2001, 44:1313-1319.
    • (2001) Arthritis Rheum , vol.44 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3    Stohl, W.4
  • 75
    • 0036144353 scopus 로고    scopus 로고
    • Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome
    • Groom J., Kalled S.L., Cutler A.H., Olson C., Woodcock S.A., Schneider P., et al. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest 2002, 109:59-68.
    • (2002) J Clin Invest , vol.109 , pp. 59-68
    • Groom, J.1    Kalled, S.L.2    Cutler, A.H.3    Olson, C.4    Woodcock, S.A.5    Schneider, P.6
  • 76
    • 0037344227 scopus 로고    scopus 로고
    • Attenuated apoptosis of B cell activating factor-expressing cells in primary Sjögren's syndrome
    • Szodoray P., Jellestad S., Teague M.O., Jonsson R. Attenuated apoptosis of B cell activating factor-expressing cells in primary Sjögren's syndrome. Lab Invest 2003, 83:357-365.
    • (2003) Lab Invest , vol.83 , pp. 357-365
    • Szodoray, P.1    Jellestad, S.2    Teague, M.O.3    Jonsson, R.4
  • 77
    • 0037310430 scopus 로고    scopus 로고
    • The level of BLyS (BAFF) correlates with the titer of autoantibodies in human Sjögren's syndrome
    • Mariette X., Roux S., Zhang J., Bengoufa D., Lavie F., Zhou T., et al. The level of BLyS (BAFF) correlates with the titer of autoantibodies in human Sjögren's syndrome. Ann Rheum Dis 2003, 62:168-171.
    • (2003) Ann Rheum Dis , vol.62 , pp. 168-171
    • Mariette, X.1    Roux, S.2    Zhang, J.3    Bengoufa, D.4    Lavie, F.5    Zhou, T.6
  • 80
    • 3042569128 scopus 로고    scopus 로고
    • Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis
    • Thangarajh M., Gomes A., Masterman T., Hillert J., Hjelmström P. Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J Neuroimmunol 2004, 152:183-190.
    • (2004) J Neuroimmunol , vol.152 , pp. 183-190
    • Thangarajh, M.1    Gomes, A.2    Masterman, T.3    Hillert, J.4    Hjelmström, P.5
  • 82
    • 33845864446 scopus 로고    scopus 로고
    • High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura
    • Emmerich F., Bal G., Barakat A., Milz J., Mϋhle C., Martinez-Gamboa L., et al. High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura. Br J Haematol 2006, 136:309-314.
    • (2006) Br J Haematol , vol.136 , pp. 309-314
    • Emmerich, F.1    Bal, G.2    Barakat, A.3    Milz, J.4    Mϋhle, C.5    Martinez-Gamboa, L.6
  • 83
    • 34250327100 scopus 로고    scopus 로고
    • Elevated serum BAFF levels in patients with autoimmune hepatitis
    • Migita K., Abiru S., Maeda Y., Nakamura M., Komori A., Ito M., et al. Elevated serum BAFF levels in patients with autoimmune hepatitis. Hum Immunol 2007, 68:586-591.
    • (2007) Hum Immunol , vol.68 , pp. 586-591
    • Migita, K.1    Abiru, S.2    Maeda, Y.3    Nakamura, M.4    Komori, A.5    Ito, M.6
  • 84
    • 0036940946 scopus 로고    scopus 로고
    • Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes
    • Mackay I.R., Groom J., Mackay C.R. Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes. Autoimmunity 2002, 35:551-553.
    • (2002) Autoimmunity , vol.35 , pp. 551-553
    • Mackay, I.R.1    Groom, J.2    Mackay, C.R.3
  • 85
    • 33749514258 scopus 로고    scopus 로고
    • Elevated serum B-lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: Association with autoimmunity
    • Toubi E., Gordon S., Kessel A., Rosner I., Rozenbaum M., Shoenfeld Y., et al. Elevated serum B-lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: Association with autoimmunity. J Autoimmun 2006, 27:134-139.
    • (2006) J Autoimmun , vol.27 , pp. 134-139
    • Toubi, E.1    Gordon, S.2    Kessel, A.3    Rosner, I.4    Rozenbaum, M.5    Shoenfeld, Y.6
  • 86
    • 0037108490 scopus 로고    scopus 로고
    • BLyS and APRIL form biologically active heterodimers that are expressed in patients with systemic immune-based rheumatic diseases
    • Roschke V., Sosnovtseva S., Ward C.D., Hong J.S., Smith R., Albert V., et al. BLyS and APRIL form biologically active heterodimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol 2002, 169:4314-4321.
    • (2002) J Immunol , vol.169 , pp. 4314-4321
    • Roschke, V.1    Sosnovtseva, S.2    Ward, C.D.3    Hong, J.S.4    Smith, R.5    Albert, V.6
  • 88
    • 34447535192 scopus 로고    scopus 로고
    • Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion
    • Katsenelson N., Kanswal S., Puig M., Mostowski H., Verthelyi D., Akkoyunlu M. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur J Immunol 2007, 37:1785-1795.
    • (2007) Eur J Immunol , vol.37 , pp. 1785-1795
    • Katsenelson, N.1    Kanswal, S.2    Puig, M.3    Mostowski, H.4    Verthelyi, D.5    Akkoyunlu, M.6
  • 89
    • 49649119208 scopus 로고    scopus 로고
    • Excessive production of IFN-{gamma} in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B
    • Harigai M., Kawamoto M., Hara M., Kubota T., Kamatani N., Miyasaka N. Excessive production of IFN-{gamma} in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol 2008, 181:2211-2219.
    • (2008) J Immunol , vol.181 , pp. 2211-2219
    • Harigai, M.1    Kawamoto, M.2    Hara, M.3    Kubota, T.4    Kamatani, N.5    Miyasaka, N.6
  • 91
    • 0141643347 scopus 로고    scopus 로고
    • {Delta}BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF
    • Gavin A.L., Aït-Azzouzene D., Ware C.F., Namazee D. {Delta}BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. J Biol Chem 2003, 278:38220-38228.
    • (2003) J Biol Chem , vol.278 , pp. 38220-38228
    • Gavin, A.L.1    Aït-Azzouzene, D.2    Ware, C.F.3    Namazee, D.4
  • 92
    • 77956924542 scopus 로고    scopus 로고
    • The late news on BAFF in autoimmune diseases
    • Youinou P., Pers J. The late news on BAFF in autoimmune diseases. Autoimmun Rev 2010, 9:804-806.
    • (2010) Autoimmun Rev , vol.9 , pp. 804-806
    • Youinou, P.1    Pers, J.2
  • 93
    • 21244506678 scopus 로고    scopus 로고
    • {Delta}BAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models
    • Gavin A.L., Duong B., Skog P., Aït-Azzouzene D., Greaves D.R., Scott M.L., et al. {Delta}BAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models. J Immunol 2005, 175:319-328.
    • (2005) J Immunol , vol.175 , pp. 319-328
    • Gavin, A.L.1    Duong, B.2    Skog, P.3    Aït-Azzouzene, D.4    Greaves, D.R.5    Scott, M.L.6
  • 94
    • 0035129411 scopus 로고    scopus 로고
    • Interleukin 10 - a new therapeutic target in systemic lupus erythematosus?
    • Emilie D., Mariette X. Interleukin 10 - a new therapeutic target in systemic lupus erythematosus?. Joint Bone Spine 2001, 68:4-5.
    • (2001) Joint Bone Spine , vol.68 , pp. 4-5
    • Emilie, D.1    Mariette, X.2
  • 95
    • 0037108354 scopus 로고    scopus 로고
    • The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity
    • Wols M.H.A., Underhill G.H., Kansas G.S., Witte P.L. The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J Immunol 2002, 169:4213-4221.
    • (2002) J Immunol , vol.169 , pp. 4213-4221
    • Wols, M.H.A.1    Underhill, G.H.2    Kansas, G.S.3    Witte, P.L.4
  • 96
    • 62649159900 scopus 로고    scopus 로고
    • CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
    • Chevrier S., Genton C., Kallies A., Karnowski A., Otten L.A., Malissen B., et al. CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci USA 2009, 106:3895-3900.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3895-3900
    • Chevrier, S.1    Genton, C.2    Kallies, A.3    Karnowski, A.4    Otten, L.A.5    Malissen, B.6
  • 97
    • 34247562214 scopus 로고    scopus 로고
    • B cell targeted therapy in autoimmunity
    • Blank M., Shoenfeld Y. B cell targeted therapy in autoimmunity. J Autoimmun 2007, 28:62-68.
    • (2007) J Autoimmun , vol.28 , pp. 62-68
    • Blank, M.1    Shoenfeld, Y.2
  • 100
    • 18844447818 scopus 로고    scopus 로고
    • The role of APRIL and BAFF in lymphocyte activation
    • Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol 2005, 17:282-289.
    • (2005) Curr Opin Immunol , vol.17 , pp. 282-289
    • Schneider, P.1
  • 101
    • 38149098399 scopus 로고    scopus 로고
    • B cell-directed therapies for autoimmune disease and correlates of disease response and relapse
    • Levesque M.C., Clair E.W. B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. J Allergy Clin Immunol 2008, 121:13-21.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 13-21
    • Levesque, M.C.1    Clair, E.W.2
  • 102
    • 67349186964 scopus 로고    scopus 로고
    • Critical analysis of rituximab-induced serological changes in connective tissue diseases
    • Cornec D., Avouac J., Youinou P., Saraux A. Critical analysis of rituximab-induced serological changes in connective tissue diseases. Autoimmun Rev 2009, 8:515-519.
    • (2009) Autoimmun Rev , vol.8 , pp. 515-519
    • Cornec, D.1    Avouac, J.2    Youinou, P.3    Saraux, A.4
  • 103
    • 1842633887 scopus 로고    scopus 로고
    • Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    • Lesley R., Xu Y., Kalled S.L., Hess D.M., Schwab S.R., Shu H.B., et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004, 20:441-453.
    • (2004) Immunity , vol.20 , pp. 441-453
    • Lesley, R.1    Xu, Y.2    Kalled, S.L.3    Hess, D.M.4    Schwab, S.R.5    Shu, H.B.6
  • 104
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    • Liang B., Gardner D.B., Griswold D.E., Bugelski P.J., Song X.Y.R. Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 2006, 119:296-305.
    • (2006) Immunology , vol.119 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Song, X.Y.R.5
  • 105
    • 70349397424 scopus 로고    scopus 로고
    • Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus
    • Chong B.F., Mohan C. Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus. Expert Opin Ther Targets 2009, 13:1147-1153.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 1147-1153
    • Chong, B.F.1    Mohan, C.2


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