메뉴 건너뛰기




Volumn 65, Issue SUPPL. 3, 2006, Pages

The BLyS/BAFF family of ligands and receptors: Key targets in the therapy and understanding of autoimmunity

Author keywords

[No Author keywords available]

Indexed keywords

APRIL PROTEIN; B CELL MATURATION ANTIGEN; B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; B LYMPHOCYTE RECEPTOR 3; INTERLEUKIN 4; UNCLASSIFIED DRUG;

EID: 33750341510     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2006.058412     Document Type: Conference Paper
Times cited : (45)

References (37)
  • 1
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    • Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56.
    • (1999) J Exp Med , vol.189 , pp. 1747-1756
    • Schneider, P.1    MacKay, F.2    Steiner, V.3    Hofmann, K.4    Bodmer, J.L.5    Holler, N.6
  • 2
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3    Pieri, K.4    LaFleur, D.W.5    Feng, P.6
  • 3
    • 0036634390 scopus 로고    scopus 로고
    • BAFF: A fundamental survival factor for B cells
    • Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2002;2:465-75.
    • (2002) Nat Rev Immunol , vol.2 , pp. 465-475
    • Mackay, F.1    Browning, J.L.2
  • 4
    • 0142218540 scopus 로고    scopus 로고
    • Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease
    • Melchers F. Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease. Ann Rheum Dis 2003;62(suppl 2):ii25-7.
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL. 2
    • Melchers, F.1
  • 5
    • 9644266695 scopus 로고    scopus 로고
    • The BLyS family of ligands and receptors: An archetype for niche-specific homeostatic regulation
    • Cancro MP. The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation. Immunol Rev 2004;202:237-49.
    • (2004) Immunol Rev , vol.202 , pp. 237-249
    • Cancro, M.P.1
  • 6
    • 16844373775 scopus 로고    scopus 로고
    • Homeostatic niche specification among naive and activated B cells: A growing role for the BLyS family of receptors and ligands
    • Crowley JE, Treml LS, Stadanlick JE, Carpenter E, Cancro MP. Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin Immunol 2005;17:193-9.
    • (2005) Semin Immunol , vol.17 , pp. 193-199
    • Crowley, J.E.1    Treml, L.S.2    Stadanlick, J.E.3    Carpenter, E.4    Cancro, M.P.5
  • 7
    • 16244423682 scopus 로고    scopus 로고
    • The role of BAFF in immune function and implications for autoimmunity
    • Kalled SL. The role of BAFF in immune function and implications for autoimmunity. Immunol Rev 2005;204:43-54.
    • (2005) Immunol Rev , vol.204 , pp. 43-54
    • Kalled, S.L.1
  • 8
    • 18844447818 scopus 로고    scopus 로고
    • The role of APRIL and BAFF in lymphocyte activation
    • Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol 2005;17:282-9.
    • (2005) Curr Opin Immunol , vol.17 , pp. 282-289
    • Schneider, P.1
  • 9
    • 0036306125 scopus 로고    scopus 로고
    • B lymphocyte stimulator (BLyS): A therapeutic trichotomy for the treatment of B lymphocyte diseases
    • Nardelli B, Moore PA, Li Y, Hilbert DS. B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma 2002;43:1367-73.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1367-1373
    • Nardelli, B.1    Moore, P.A.2    Li, Y.3    Hilbert, D.S.4
  • 11
    • 2942737094 scopus 로고    scopus 로고
    • A therapeutic role for BLyS antagonists
    • Stahl W. A therapeutic role for BLyS antagonists. Lupus 2004;13:317-22.
    • (2004) Lupus , vol.13 , pp. 317-322
    • Stahl, W.1
  • 12
    • 16544363235 scopus 로고    scopus 로고
    • Human B lymphocyte malignancies: Exploitation of BLyS and APRIL and their receptors
    • Jelinek DF, Darce JR. Human B lymphocyte malignancies: exploitation of BLyS and APRIL and their receptors. Curr Dir Autoimmun 2005;8:266-88.
    • (2005) Curr Dir Autoimmun , vol.8 , pp. 266-288
    • Jelinek, D.F.1    Darce, J.R.2
  • 13
    • 16544378081 scopus 로고    scopus 로고
    • The BAFF/APRIL system: An important player in systemic rheumatic diseases
    • Mackay F, Sierro F, Grey ST, Gordon TP. The BAFF/APRIL system: an important player in systemic rheumatic diseases. Curr Dir Autoimmun 2005;8:243-65.
    • (2005) Curr Dir Autoimmun , vol.8 , pp. 243-265
    • Mackay, F.1    Sierro, F.2    Grey, S.T.3    Gordon, T.P.4
  • 14
    • 18644369740 scopus 로고    scopus 로고
    • BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2
    • Kayogaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity 2002;17:515-24.
    • (2002) Immunity , vol.17 , pp. 515-524
    • Kayogaki, N.1    Yan, M.2    Seshasayee, D.3    Wang, H.4    Lee, W.5    French, D.M.6
  • 15
    • 20044366916 scopus 로고    scopus 로고
    • Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding
    • Hymowitz SG, Patel DR, Wallweber HJ, Runyon S, Yan M, Yin J, et al. Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding. J Biol Chem 2005;280:7218-27.
    • (2005) J Biol Chem , vol.280 , pp. 7218-7227
    • Hymowitz, S.G.1    Patel, D.R.2    Wallweber, H.J.3    Runyon, S.4    Yan, M.5    Yin, J.6
  • 16
    • 0037846097 scopus 로고    scopus 로고
    • BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
    • Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, et al. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry 2003;42:5977-83.
    • (2003) Biochemistry , vol.42 , pp. 5977-5983
    • Gordon, N.C.1    Pan, B.2    Hymowitz, S.G.3    Yin, J.4    Kelley, R.F.5    Cochran, A.G.6
  • 17
    • 0026644137 scopus 로고
    • Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigen(hi) and exhibit unique signaling characteristics
    • Allman DM, Ferguson SE, Cancro MP. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigen(hi) and exhibit unique signaling characteristics. J Immunol 1992;149:2533-40.
    • (1992) J Immunol , vol.149 , pp. 2533-2540
    • Allman, D.M.1    Ferguson, S.E.2    Cancro, M.P.3
  • 18
    • 0027379716 scopus 로고
    • Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
    • Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol 1993;151:4431-44.
    • (1993) J Immunol , vol.151 , pp. 4431-4444
    • Allman, D.M.1    Ferguson, S.E.2    Lentz, V.M.3    Cancro, M.P.4
  • 19
    • 0031738699 scopus 로고    scopus 로고
    • Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
    • Rolink AG, Andersson J, Melchers F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur J Immunol 1998;28:3738-48.
    • (1998) Eur J Immunol , vol.28 , pp. 3738-3748
    • Rolink, A.G.1    Andersson, J.2    Melchers, F.3
  • 20
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Loder F, Mutschler B, Ray RJ, Paige CJ, Sideras P, Torres R, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med 1999;190:75-89.
    • (1999) J Exp Med , vol.190 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6
  • 21
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 2001;167:6834-40.
    • (2001) J Immunol , vol.167 , pp. 6834-6840
    • Allman, D.1    Lindsley, R.C.2    DeMuth, W.3    Rudd, K.4    Shinton, S.A.5    Hardy, R.R.6
  • 22
    • 0942268734 scopus 로고    scopus 로고
    • Peripheral B-cell maturation: The intersection of selection and homeostasis
    • Cancro MP. Peripheral B-cell maturation: the intersection of selection and homeostasis. Immunol Rev 2004;197:89-101.
    • (2004) Immunol Rev , vol.197 , pp. 89-101
    • Cancro, M.P.1
  • 23
    • 0037097665 scopus 로고    scopus 로고
    • Cutting edge: BLyS enables survival of transitional and mature β cells through distinct mediators
    • Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge: BLyS enables survival of transitional and mature β cells through distinct mediators. J Immunol 2002;168:5993-6.
    • (2002) J Immunol , vol.168 , pp. 5993-5996
    • Hsu, B.L.1    Harless, S.M.2    Lindsley, R.C.3    Hilbert, D.M.4    Cancro, M.P.5
  • 24
    • 17944375043 scopus 로고    scopus 로고
    • TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS
    • Gross JA, Dillon SR, Mudri S, Johnston J, Littau A, Roque R, et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity 2001;15:289-302.
    • (2001) Immunity , vol.15 , pp. 289-302
    • Gross, J.A.1    Dillon, S.R.2    Mudri, S.3    Johnston, J.4    Littau, A.5    Roque, R.6
  • 25
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann B, Gommerman JL, Vora K, Cachero TG, Shulga-Morskaya S, Dobles M, et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001;293:2111-14.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1    Gommerman, J.L.2    Vora, K.3    Cachero, T.G.4    Shulga-Morskaya, S.5    Dobles, M.6
  • 26
    • 0035846593 scopus 로고    scopus 로고
    • Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers
    • Harless SM, Lentz VM, Sah AP, Hsu BL, Clise-Dwyer K, Hilbert DM, et al. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol 2001;11:1986-9.
    • (2001) Curr Biol , vol.11 , pp. 1986-1989
    • Harless, S.M.1    Lentz, V.M.2    Sah, A.P.3    Hsu, B.L.4    Clise-Dwyer, K.5    Hilbert, D.M.6
  • 27
    • 0035797908 scopus 로고    scopus 로고
    • Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
    • Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S, et al. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr Biol 2001;11:1547-52.
    • (2001) Curr Biol , vol.11 , pp. 1547-1552
    • Yan, M.1    Brady, J.R.2    Chan, B.3    Lee, W.P.4    Hsu, B.5    Harless, S.6
  • 29
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
    • Hartley SB, Crosbie J, Brink R, Kantor AB, Basten A, Goodnow CC. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 1991;353:765-9.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 30
    • 0028064578 scopus 로고
    • Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
    • Cyster JG, Hartley SB, Goodnow CC. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 1994;371:389-95.
    • (1994) Nature , vol.371 , pp. 389-395
    • Cyster, J.G.1    Hartley, S.B.2    Goodnow, C.C.3
  • 31
    • 0028057419 scopus 로고
    • Reduced life span of anergic self-reactive B cells in a double-transgenic model
    • Fulcher DA, Basten A. Reduced life span of anergic self-reactive B cells in a double-transgenic model. J Exp Med 1994;179:125-34.
    • (1994) J Exp Med , vol.179 , pp. 125-134
    • Fulcher, D.A.1    Basten, A.2
  • 32
    • 0030008694 scopus 로고    scopus 로고
    • The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help
    • Fulcher DA, Lyons AB, Korn SL, Cook MC, Koleda C, Parish C, et al. The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J Exp Med 1996;183:2313-28.
    • (1996) J Exp Med , vol.183 , pp. 2313-2328
    • Fulcher, D.A.1    Lyons, A.B.2    Korn, S.L.3    Cook, M.C.4    Koleda, C.5    Parish, C.6
  • 33
    • 0031004822 scopus 로고    scopus 로고
    • Signaling thresholds and interclonal competition in preimmune B-cell selection
    • Cyster JG. Signaling thresholds and interclonal competition in preimmune B-cell selection. Immunol Rev 1997;156:87-101.
    • (1997) Immunol Rev , vol.156 , pp. 87-101
    • Cyster, J.G.1
  • 34
    • 1842633887 scopus 로고    scopus 로고
    • Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    • Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, Shu HB, et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004;20:441-53.
    • (2004) Immunity , vol.20 , pp. 441-453
    • Lesley, R.1    Xu, Y.2    Kalled, S.L.3    Hess, D.M.4    Schwab, S.R.5    Shu, H.B.6
  • 35
    • 2942518502 scopus 로고    scopus 로고
    • Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
    • Thien M, Phan TG, Gardam S, Amesbury M, Basten A, Mackay F, et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 2004;20:785-98.
    • (2004) Immunity , vol.20 , pp. 785-798
    • Thien, M.1    Phan, T.G.2    Gardam, S.3    Amesbury, M.4    Basten, A.5    Mackay, F.6
  • 36
    • 33646891951 scopus 로고    scopus 로고
    • Space, selection and surveillance: Setting boundaries with BLyS
    • Miller JP, Stadanlick JE, Cancro MP. Space, selection and surveillance: setting boundaries with BLyS. J Immunol 2006;176:6405-10.
    • (2006) J Immunol , vol.176 , pp. 6405-6410
    • Miller, J.P.1    Stadanlick, J.E.2    Cancro, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.