Pathophysiological response to hypoxia - From the molecular mechanisms of malady to drug discovery: Epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes

Journal of Pharmacological Sciences

Volumn 115, Issue 4, 2011, Pages 453-458

  Mimura, Imari ^a,b   Tanaka, Tetsuhiro ^a   Wada, Youichiro ^b   Kodama, Tatsuhiko ^b   Nangaku, Masaomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Epigenetics; Histone demethylase; Hypoxia; Hypoxia inducible factor (HIF); JMJD1A

Indexed keywords

HISTONE DEMETHYLASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METHYLTRANSFERASE; OXYGENASE; PROTEIN JARID1C; PROTEIN JMJD1A; PROTEIN JMJD2B; PROTEIN JMJD2C; PROTEIN KDM6A; REGULATOR PROTEIN; REPTIN; SIRTUIN 1; SIRTUIN 6; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

CANCER GROWTH; CANCER THERAPY; CHROMATIN STRUCTURE; CONFORMATIONAL TRANSITION; DEMETHYLATION; DNA MODIFICATION; EPIGENETICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HYPOXIA; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METHYLATION; SHORT SURVEY;

EID: 79955014357     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10R19FM     Document Type: Short Survey

References (41)

1. Park JW, Chun YS, Kim MS. Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools. J Pharmacol Sci. 2004;94:221-232.
2. Gordon JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev. 2007;17: 71-77. (Pubitemid 46109295)
3. Tanaka T, Wiesener M, Bernhardt W, Eckard KU, Warnecke C. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoic gene induction. Biochem J. 2009;424:143-151.
4. Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature. 2001;414:550-554. (Pubitemid 33131538)
5. Maynard MA, Evans AJ, Hosomi T, Hara S, Jewett MA, Ohh M. Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB J. 2005; 19:1396-1406. (Pubitemid 41278998)
6. Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008; 30;393-402. (Pubitemid 351681994)
7. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721-732. (Pubitemid 37328811)
8. Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol. 2004;5:343-354. (Pubitemid 38579472)
9. Yang J, Ledaki I, Turley H, Gatter KC, Montero JC, Li JL, et al. Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases. Ann N Y Acad Sci. 2009;1177:185-197.
10. Calvani M, Trisciuoglio D, Bergamaschi C, Shoemaker RH, Melillo G. Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. Cancer Res. 2008;68:285-291. (Pubitemid 351380130)
11. Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 2006; 441;437-443. (Pubitemid 44050138)
12. Robin ED, Murphy BJ, Theodore J. Coordinate regulation of glycolysis by hypoxia in mammalian cells. J Cell Physiol. 1984; 118:287-290. (Pubitemid 14162998)
13. Lan F, Nottke AC, Shi Y. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol. 2008;20: 316-325.
14. Cloos PA, Christensen J, Agger K, Helin K. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev. 2008;22:1115-1140. (Pubitemid 351656572)
15. Klose RJ, Y Zhang. Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol. 2007; 8:307-318. (Pubitemid 46474659)
16. Ruthenburg AJ, Allis CD, Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell. 2007;25:15-30. (Pubitemid 46049068)
17. Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res. 2008;640:174-179.
18. Shi Y. Histone lysine demethylases: emerging roles in development, physiology and disease. Nat Rev Genet. 2007;8:829-833. (Pubitemid 47609092)
19. Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, Gunther T, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. 2005;437:436-439. (Pubitemid 41613508)
20. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004;119:941-953. (Pubitemid 40037608)
21. Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, et al. Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun. 2008; 372:892-897.
22. Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, et al. Regulation of Jumonjidomain-containing histone demethylases by hypoxiainducible factor (HIF)-1alpha. Biochem J. 2008;416:387-394.
23. Beyer S, Kristensen MM, Jensen KS, Johansen JV, Staller P. The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem. 2008; 283:36542-36552.
24. Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, et al. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A. 2008;106:4260-4265.
25. Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, et al. JHDM2a, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006;125:483-495.
26. Hoog C, Schalling M, Grunder-Brundell E, Daneholt B. Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein. Mol Reprod Dev. 1991;30:173-181.
27. Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature. 2007;450:119-123. (Pubitemid 350070569)
28. Tateishi K, Okada Y, Kallin EM, Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature. 2009;458:757-761.
29. Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, et al. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells. 2009;14:991-1001.
30. Melillo G. Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res. 2006;4:601-605. (Pubitemid 44497213)
31. Dhirst MW, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 2008;8:425-437. (Pubitemid 351744964)
32. Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, et al. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and Hypoxia, and is a key mediator of estrogen induced growth. Cancer Res. 2010;15:6456-6466.
33. Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst. 2002;21: 309-314. (Pubitemid 32219818)
34. Cao P, Deng Z, Wan M, Huang W, Cramer SD, Xu J, et al. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β. Mol Cancer. 2010;9:108.
35. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. Role of histone H3 lysine 27 methylation in Polycombgroup silencing. Science. 2002;298:1039-1043. (Pubitemid 35247314)
36. Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal cell carcinoma reveals inactivation of histone modifying genes. Nature. 2010;463: 360-363.
37. van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009;41: 521-523.
38. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia- inducible factor 1 alpha. Mol Cell. 2010;38:864-878.
39. Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin1. Science. 2009; 324:1289-1293.
40. Zhong L, DUrso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via HIF-1β. Cell. 2010;140:280-293.
41. Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, et al. Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell. 2010;39:71-85.