Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade

Neuropharmacology

Volumn 51, Issue 3, 2006, Pages 474-486

  Takada Takatori, Yuki ^a   Kume, Toshiaki ^a   Sugimoto, Mitsuhiro ^a   Katsuki, Hiroshi ^a   Sugimoto, Hachiro ^a   Akaike, Akinori ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Cortical culture; Glutamate; Neurotoxicity; Nicotinic acetylcholine receptor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHOLINESTERASE INHIBITOR; DIHYDRO BETA ERYTHROIDINE; DONEPEZIL; GALANTAMINE; GLUTAMIC ACID; JANUS KINASE 2; MECAMYLAMINE; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; TACRINE;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FETUS; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL COUNT; CELLS, CULTURED; CEREBRAL CORTEX; CHOLINERGIC ANTAGONISTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GLUTAMIC ACID; NEURONS; NEUROTOXICITY SYNDROMES; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; TIME FACTORS;

EID: 33747044365     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.04.007     Document Type: Article

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