Compound Astragalus and Salvia miltiorrhiza Extract exerts anti-fibrosis by mediating TGF-β/Smad signaling in myofibroblasts

Journal of Ethnopharmacology

Volumn 118, Issue 2, 2008, Pages 264-270

  Yang, Yan ^a,b,c   Yang, Sen ^b,c   Chen, Minzhu ^a   Zhang, Xiaoxiang ^d   Zou, Yuhong ^a,e   Zhang, Xuejun ^b,c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b First Affiliated Hospital   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d HEFEI UNIVERSITY OF TECHNOLOGY   (China)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Astragalus membranaceus Bunge (Leguminosae); Compound Astragalus and Salvia miltiorrhiza Extract (CASE); Hepatic fibrosis; Myofibroblast; Salvia miltiorhiza Bunge (Lamiaceae); Smad; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ASTRAGALUS EXTRACT; CARBON TETRACHLORIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SALVIA MILTIORRHIZA EXTRACT; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MALE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; TALUS; TREATMENT RESPONSE; WESTERN BLOTTING;

ANIMALS; ASTRAGALUS MEMBRANACEUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FEMALE; FIBROBLASTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER CIRRHOSIS; MALE; PHOSPHORYLATION; PLANT EXTRACTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

ASTRAGALUS (ANGIOSPERM); ASTRAGALUS MEMBRANACEUS; FABACEAE; LAMIACEAE; RATTUS; SALVIA MILTIORRHIZA;

EID: 45449097043     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.04.012     Document Type: Article

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