Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment

Toxicology and Applied Pharmacology

Volumn 252, Issue 3, 2011, Pages 259-267

  Mota, Linda C ^a   Barfield, Christina ^a   Hernandez, Juan P ^b   Baldwin, William S ^a  

^a CLEMSON UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT EL PASO   (United States)

Author keywords

CAR; Nonylphenol; P450s; PXR

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 3A; NONYLPHENOL; PREGNANE X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DRUG STRUCTURE; ENZYME INDUCTION; ENZYME METABOLISM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSACTIVATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DNA; ENZYME INDUCTION; FEMALE; HEPATOCYTES; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOBLOTTING; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOLS; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; RECEPTORS, STEROID;

MUS;

EID: 79954629616     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.02.017     Document Type: Article

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