Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists

Toxicological Sciences

Volumn 81, Issue 1, 2004, Pages 69-77

  Wilson, Vickie S ^a   Bobseine, Kathy ^a   Gray Jr , L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Estrogen responsive luciferase reporter; Estrogenicity; in vitro screening assay

Indexed keywords

1,1,1 TRICHLORO 2,2 BIS(4 HYDROXYPHENYL)ETHANE; 4 NONYLPHENOL; ANDROSTANOLONE; ANTIESTROGEN; CADMIUM; DEXAMETHASONE; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; FULVESTRANT; GENISTEIN; LUCIFERASE; METHOXYCHLOR; TAMOXIFEN; TRICHLOROETHANE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; GENE CONSTRUCT; GENE EXPRESSION SYSTEM; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; PROMOTER REGION; REPORTER GENE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BREAST NEOPLASMS; CELL LINE; CLONING, MOLECULAR; DEXAMETHASONE; DIHYDROTESTOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; ESTROGENS, NON-STEROIDAL; FEMALE; GENES, REPORTER; HUMANS; LIGANDS; LIGHT; LUCIFERASES; LUMINESCENT MEASUREMENTS; PLASMIDS; RECEPTORS, ESTROGEN; TATA BOX; TRANSFECTION;

EID: 4444304724     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh180     Document Type: Article

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