Constitutive androgen receptor-null mice are sensitive to the toxic effects of parathion: Association with reduced cytochrome P450-mediated parathion metabolism

Drug Metabolism and Disposition

Volumn 38, Issue 9, 2010, Pages 1582-1588

  Mota, Linda C ^a   Hernandez, Juan P ^b,c   Baldwin, William S ^a  

^a CLEMSON UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT EL PASO   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B9; CYTOCHROME P450 3A11; NITROPHENOL; PARAOXON; PARATHION;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; INSECTICIDES; MALE; MICE; MICE, KNOCKOUT; PARATHION;

ANIMALIA; MUS;

EID: 77955999905     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.032961     Document Type: Article

References (40)

1. 14C]methyl parathion in rats. Toxicol Sci 53:5-12.
2. Baldwin WS and Roling JA (2009) A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures. Toxicol Sci 107:93-105.
3. Costa LG, McDonald BE, Murphy SD, Omenn GS, Richter RJ, Motulsky AG, and Furlong CE (1990) Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats. Toxicol Appl Pharmacol 103:66-76.
4. Environmental Protection Agency (2002) Organophosphate Pesticides: Revised Cumulative Risk Assessment: Executive Summary, p 11, Environmental Protection Agency, Washington, DC.
5. Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, and Olson JR (2007) Human hepatic cytochrome P450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos 35:189-193.
6. Gallow MA and Lawryk NJ (1991) Organophosphorus Pesticides. Academic Press, San Diego.
7. Green T, Swain C, Van Miller JP, and Joiner RL (2003) Absorption, bioavailability, and metabolism of para-nonylphenol in the rat. Regul Toxicol Pharmacol 38:43-51.
8. Griffin P, Mason H, Heywood K, and Cocker J (1999) Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup Environ Med 56:10-13.
9. Hashita T, Sakuma T, Akada M, Nakajima A, Yamahara H, Ito S, Takesako H, and Nemoto N (2008) Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene. Drug Metab Dispos 36:1080-1087.
10. Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, and Baldwin WS (2007) The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicol Sci 98:416-426. (Pubitemid 47244812)
11. Hernandez JP, Mota LC, and Baldwin WS (2009a) Activation of CAR and PXR by dietary, environmental and occupational chemicals alters drug metabolism, intermediary metabolism, and cell proliferation. Curr Pharmacogenomics Person Med 7:81-105.
12. Hernandez JP, Mota LC, Huang W, Moore DD, and Baldwin WS (2009b) Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR). Toxicology 256:53-64.
13. Huang S and Huang K (2007) Increased U.S. imports of fresh fruits and vegetables, in A Report from the Economic Research Service, p 20, U.S. Department of Agriculture, Washington, DC.
14. Iven H and Feldbusch E (1983) Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Naunyn Schmiedebergs Arch Pharmacol 324: 153-159.
15. Kiely T, Donaldson D, and Grube R (2004) Pesticide Industry Sales and Usage: 2000-2001 Market Estimates, p 33, Biological and Economic Analysis Division Office of Pesticide Programs, Office of Prevention, Pesticides, and Toxic Substances. U.S. Environmental Protection Agency, Washington, DC.
16. Kim DO, Lee SK, Jeon TW, Jin CH, Hyun SH, Kim EJ, Moon GI, Kim JA, Lee ES, Lee BM, et al. (2005) Role of metabolism in parathion-induced hepatotoxicity and immunotoxicity. J Toxicol Environ Health A 68:2187-2205.
17. Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, and Windshügel B (2008) Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor. Biochem Pharmacol 76:1288-1297.
18. Maxwell DM (1992) The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds. Toxicol Appl Pharmacol 114:306-312.
19. Muller PY, Janovjak H, Miserez AR, and Dobbie Z (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32:1372-1379.
20. Muller S, Schmid P, and Schlatter C (1998) Pharmacokinetic behavior of 4-nonylphenol in humans. Environ Toxicol Pharmacol 5:257-265.
21. Murcia AM and Stashenko E (2008) Determinacion de plaguicidas organofosforados en vegetales producidos en Colombia. Agro Sur 36:71-81.
22. Mutch E and Williams FM (2006) Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology 224:22-32. (Pubitemid 43912967)
23. Padilla S, Buzzard J, and Moser VC (2000) Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos. Neurotoxicology 21:49-56.
24. Perez MA, Segura A, Garcia R, Colinas T, Perez M, Vazquez A, and Navarro H (2009) Residuos de plaguicidas organofosforados en cabezuela de brocoli (Brassica oleracea) determinados por cromatografia de gases. Rev Int Contam Ambient 25:103-110.
25. Parliamentary Office of Science and Technology (1998) Post Note 122: Organophosphates, Parliamentary Office of Science and Technology, London.
26. Ragnarsdottir KV (2000) Environmental fate and toxicology of organophosphate pesticides. J Geol Soc 157:859-876.
27. Reiner E, Pavković E, Radić Z, and Simeon V (1993) Differentiation of esterases reacting with organophosphorus compounds. Chem Biol Interact 87:77-83.
28. Saller J, Reyes P, Maldonado PA, Gibbs SG, and Byrd TL (2007) Children's exposure to pesticides used in homes and farms. J Environ Health 69:27-31. (Pubitemid 46432819)
29. Sheets LP (2000) A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicology 21:57-63.
30. Singh BK and Walker A (2006) Microbial degradation of organophosphorus compounds. FEMS Microbiol Rev 30:428-471.
31. Sobarzo C and Bustos-Obregón E (2000) Sperm quality in mice acutely treated with parathion. Asian J Androl 2:147-150.
32. Sueyoshi T and Negishi M (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41:123-143.
33. Sultatos LG and Minor LD (1986) Factors affecting the biotransformation of the pesticide parathion by the isolated perfused mouse liver. Drug Metab Dispos 14:214-220.
34. Tzameli I, Pissios P, Schuetz EG, and Moore DD (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol 20:2951-2958.
35. Vyhlidal CA, Gaedigk R, and Leeder JS (2006) Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression. Drug Metab Dispos 34:131-137.
36. Wei P, Zhang J, Egan-Hafley M, Liang S, and Moore DD (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407:920-923.
37. Weitman SD, Vodicnik MJ, and Lech JJ (1983) Influence of pregnancy on parathion toxicity and disposition. Toxicol Appl Pharmacol 71:215-224.
38. Wiwi CA, Gupte M, and Waxman DJ (2004) Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4a-deficient mice. Mol Endocrinol 18:1975-1987. (Pubitemid 39006502)
39. Wortham M, Czerwinski M, He L, Parkinson A, and Wan YJ (2007) Expression of constitutive androstane receptor, hepatic nuclear factor 4 α, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metab Dispos 35:1700-1710.
40. Xu C, Wang X, and Staudinger JL (2009) Regulation of tissue-specific carboxylesterase expression by pregnane X receptor and constitutive androstane receptor. Drug Metab Dispos 37:1539-1547.