Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

Biochemical Journal

Volumn 435, Issue 3, 2011, Pages 755-769

  Mackenzie, Kirsty F ^a,b   Wallace, Derek A ^a   Hill, Elaine V ^a   Anthony, Diana F ^a   Henderson, David J P ^a   Houslay, Daniel M ^a   Arthur, J Simon C ^b   Baillie, George S ^a   Houslay, Miles D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Aryl hydrocarbon receptor interacting protein (AIP, also called XAP2); cAMP specific phosphodiesterase 4 (PDE4); Disrupted in schizophrenia 1 (DISC1); Mitogen activated protein kinase activated protein kinase 2 (MK2, also called MAPKAPK2); Protein kinase A (PKA); Tumour necrosis factor (TNF )

Indexed keywords

ADENYLATE CYCLASE; AROMATIC HYDROCARBON RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHODIESTERASE 4A5; PHOSPHODIESTERASE IV; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MACROPHAGE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 79954527672     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101184     Document Type: Article

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