Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

Cellular Signalling

Volumn 15, Issue 10, 2003, Pages 955-971

  Terry, Robert ^a   Cheung, York Fong ^b   Praestegaard, Morten ^a   Baillie, George S ^b   Huston, Elaine ^b   Gall, Irene ^b   Adams, David R ^c   Houslay, Miles D ^b  

^a BioImage AS   (Denmark)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Cyclic AMP phosphodiesterase; Green flourescent protein; PDE4A4; Protein kinase A; Rolipram

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ADENYLATE CYCLASE ACTIVATOR; CILOMILAST; CYCLIC AMP; FORSKOLIN; ISOENZYME; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PICLAMILAST; ROLIPRAM; RS 25344;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SPECIFICITY; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

RODENTIA;

EID: 0038573885     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(03)00092-5     Document Type: Article

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