메뉴 건너뛰기




Volumn 30, Issue 3, 2011, Pages 153-162

Animal models of melanoma: A somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma

Author keywords

Animal models; Melanoma; RCAS TVA

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; RETROVIRUS VECTOR;

EID: 79954466827     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.011.10007     Document Type: Review
Times cited : (24)

References (100)
  • 1
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010 [J]
    • Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010 [J]. CA Cancer J Clin, 2010,60(5):277-300.
    • (2010) CA Cancer J Clin , vol.60 , Issue.5 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3
  • 2
    • 85036693418 scopus 로고    scopus 로고
    • Seer cancer statistics review, 1975-2007, national cancer institute
    • SF A, CL K, M K, et al., eds, Bethesda, MD
    • Seer cancer statistics review, 1975-2007, national cancer institute. SF A, CL K, M K, et al., eds. SEER AYA Monograph. Bethesda, MD, 2007:53-63.
    • (2007) SEER AYA Monograph , pp. 53-63
  • 3
    • 0031421593 scopus 로고    scopus 로고
    • Malignant melanoma: Prognostic indicators [J]
    • Ahmed I. Malignant melanoma: Prognostic indicators [J]. Mayo Clin Proc, 1997,72(4):356-361.
    • (1997) Mayo Clin Proc , vol.72 , Issue.4 , pp. 356-361
    • Ahmed, I.1
  • 4
    • 78751696744 scopus 로고    scopus 로고
    • Narrative review: Braf opens the door for therapeutic advances in melanoma [J]
    • Flaherty KT. Narrative review: Braf opens the door for therapeutic advances in melanoma [J]. Ann Intern Med, 2010,153(9):587-591.
    • (2010) Ann Intern Med , vol.153 , Issue.9 , pp. 587-591
    • Flaherty, K.T.1
  • 5
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, ctivated braf in metastatic melanoma [J]
    • Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, ctivated braf in metastatic melanoma [J]. N Engl J Med, 2010,363(9):809-819.
    • (2010) N Engl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 6
    • 51749094162 scopus 로고    scopus 로고
    • From uvs to metastases: Odeling melanoma initiation and progression in the mouse [J]
    • Zaidi MR, Day CP, Merlino G. From uvs to metastases: odeling melanoma initiation and progression in the mouse [J]. J Invest Dermatol, 2008,128(10):2381-2391.
    • (2008) J Invest Dermatol , vol.128 , Issue.10 , pp. 2381-2391
    • Zaidi, M.R.1    Day, C.P.2    Merlino, G.3
  • 7
    • 0030227584 scopus 로고    scopus 로고
    • Xenograft model systems for human elanoma [J]
    • Rofstad EK, Lyng H. Xenograft model systems for human elanoma [J]. Mol Med Today, 1996,2(9):394-403.
    • (1996) Mol Med Today , vol.2 , Issue.9 , pp. 394-403
    • Rofstad, E.K.1    Lyng, H.2
  • 8
    • 22844445932 scopus 로고    scopus 로고
    • Use of human issue to assess the oncogenic activity of melanoma-associated mutations [J]
    • Chudnovsky Y, Adams AE, Robbins PB, et al. Use of human issue to assess the oncogenic activity of melanoma-associated mutations [J]. Nat Genet, 2005,37(7):745-749.
    • (2005) Nat Genet , vol.37 , Issue.7 , pp. 745-749
    • Chudnovsky, Y.1    Adams, A.E.2    Robbins, P.B.3
  • 9
    • 0027496946 scopus 로고
    • Human cytotoxic T-cells suppress he growth of spontaneous melanoma metastases in scid/hu ice [J]
    • Sabzevari H, Reisfeld RA. Human cytotoxic T-cells suppress he growth of spontaneous melanoma metastases in scid/hu ice [J]. Cancer Res, 1993,53(20):4933-4937.
    • (1993) Cancer Res , vol.53 , Issue.20 , pp. 4933-4937
    • Sabzevari, H.1    Reisfeld, R.A.2
  • 10
    • 0034897511 scopus 로고    scopus 로고
    • Mechanism of 7,12-imethylbenz [ajanthracene-induced immunotoxicity: Role of metabolic activation at the target organ [J]
    • Miyata M, Furukawa M, Takahashi K, et al. Mechanism of 7,12-imethylbenz [ajanthracene-induced immunotoxicity: Role of metabolic activation at the target organ [J]. Jpn J Pharmacol, 2001,86(3):302-309.
    • (2001) Jpn J Pharmacol , vol.86 , Issue.3 , pp. 302-309
    • Miyata, M.1    Furukawa, M.2    Takahashi, K.3
  • 11
    • 0023880172 scopus 로고
    • Protein kinase c as the receptor for the phorbol stertumor promoters: Sixth rhoads memorial award lecture [J]
    • Blumberg PM. Protein kinase c as the receptor for the phorbol stertumor promoters: sixth rhoads memorial award lecture [J]. Cancer Res, 1988,48(1):1-8.
    • (1988) Cancer Res , vol.48 , Issue.1 , pp. 1-8
    • Blumberg, P.M.1
  • 12
    • 0021220257 scopus 로고
    • Protein kinase c phosphorylation of the egf receptor at a threonine residue close to the cytoplasmic face of the plasma membrane [J]
    • Hunter T, Ling N, Cooper JA. Protein kinase c phosphorylation of the egf receptor at a threonine residue close to the cytoplasmic face of the plasma membrane [J]. Nature, 1984,311(5985):480-483.
    • (1984) Nature , vol.311 , Issue.5985 , pp. 480-483
    • Hunter, T.1    Ling, N.2    Cooper, J.A.3
  • 13
    • 33746635503 scopus 로고    scopus 로고
    • Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic cdk4 mutation [J]
    • Tormo D, Ferrer A, Gaffal E, et al. Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic cdk4 mutation [J]. Am J Pathol, 2006,169(2):665-672.
    • (2006) Am J Pathol , vol.169 , Issue.2 , pp. 665-672
    • Tormo, D.1    Ferrer, A.2    Gaffal, E.3
  • 14
    • 77955739838 scopus 로고    scopus 로고
    • Cooperativity of cdk4r24c and ras in melanoma development [J]
    • Chawla R, Procknow JA, Tantravahi RV, et al. Cooperativity of cdk4r24c and ras in melanoma development [J]. Cell Cycle, 2010,9(16):3305-3314.
    • (2010) Cell Cycle , vol.9 , Issue.16 , pp. 3305-3314
    • Chawla, R.1    Procknow, J.A.2    Tantravahi, R.V.3
  • 15
    • 48649110016 scopus 로고    scopus 로고
    • Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis [J]
    • Inoue-Narita T, Hamada K, Sasaki T, et al. Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis [J]. Cancer Res, 2008,68(14):5760-5768.
    • (2008) Cancer Res , vol.68 , Issue.14 , pp. 5760-5768
    • Inoue-Narita, T.1    Hamada, K.2    Sasaki, T.3
  • 16
    • 1542722128 scopus 로고    scopus 로고
    • Topical application of dimethylbenz [ajanthracene results in the generation of multiple melanocytic nevi in c3h/hen mice [J]
    • Elmets CA, Yusuf N, Hamza S, et al. Topical application of dimethylbenz [ajanthracene results in the generation of multiple melanocytic nevi in c3h/hen mice [J]. Toxicol Appl Pharmacol, 2004,195(3):355-360.
    • (2004) Toxicol Appl Pharmacol , vol.195 , Issue.3 , pp. 355-360
    • Elmets, C.A.1    Yusuf, N.2    Hamza, S.3
  • 17
    • 0016759357 scopus 로고
    • Splenic regulation of the clinical appearance of small tumors [J]
    • Nordlund JJ, Gershon RK. Splenic regulation of the clinical appearance of small tumors [J]. J Immunol, 1975,114(5): 1486-1490.
    • (1975) J Immunol , vol.114 , Issue.5 , pp. 1486-1490
    • Nordlund, J.J.1    Gershon, R.K.2
  • 18
    • 0016613806 scopus 로고
    • Tumor immunology with particular reference to malignant melanoma [J]
    • Maguire HC, Jr. Tumor immunology with particular reference to malignant melanoma [J]. Int J Dermatol, 1975,14(1):3-11.
    • (1975) Int J Dermatol , vol.14 , Issue.1 , pp. 3-11
    • Maguire Jr., H.C.1
  • 19
    • 0017091248 scopus 로고
    • Tumoricidal properties of mouse macrophages activated with mediators from ratlymphocytes stimulated with concanavalin a [J]
    • Fidler IJ, Darnell JH, Budmen MB. Tumoricidal properties of mouse macrophages activated with mediators from ratlymphocytes stimulated with concanavalin a [J]. Cancer Res, 1976,36(10):3608-3615.
    • (1976) Cancer Res , vol.36 , Issue.10 , pp. 3608-3615
    • Fidler, I.J.1    Darnell, J.H.2    Budmen, M.B.3
  • 20
    • 0017138981 scopus 로고
    • Organ selectivity for implantation survival and growth of b16 melanoma variant tumor lines [J]
    • Fidler IJ, Nicolson GL. Organ selectivity for implantation survival and growth of b16 melanoma variant tumor lines [J]. J Natl Cancer Inst, 1976,57(5):1199-1202.
    • (1976) J Natl Cancer Inst , vol.57 , Issue.5 , pp. 1199-1202
    • Fidler, I.J.1    Nicolson, G.L.2
  • 21
    • 77954728876 scopus 로고    scopus 로고
    • Targeted delivery of nrasq61r and cre-recombinase to post-natal melanocytes induces melanoma in ink4a/arflox/lox mice [J]
    • VanBrocklin MW, Robinson JP, Lastwika KJ, et al. Targeted delivery of nrasq61r and cre-recombinase to post-natal melanocytes induces melanoma in ink4a/arflox/lox mice [J]. Pigment Cell Melanoma Res, 2010,23(4):531-541.
    • (2010) Pigment Cell Melanoma Res , vol.23 , Issue.4 , pp. 531-541
    • Vanbrocklin, M.W.1    Robinson, J.P.2    Lastwika, K.J.3
  • 22
    • 74949097187 scopus 로고    scopus 로고
    • Mouse models for melanoma: A personal perspective [J]
    • Becker JC, Houben R, Schrama D, et al. Mouse models for melanoma: a personal perspective [J]. Exp Dermatol, 2009,19 (2):157-164
    • (2009) Exp Dermatol , vol.19 , Issue.2 , pp. 157-164
    • Becker, J.C.1    Houben, R.2    Schrama, D.3
  • 23
    • 20144387910 scopus 로고    scopus 로고
    • Potent selection of antigen loss variants of b16 melanoma following inflammatory killing of melanocytes in vivo [J]
    • Sanchez-Perez L, Kottke T, Diaz RM, et al. Potent selection of antigen loss variants of b16 melanoma following inflammatory killing of melanocytes in vivo [J]. Cancer Res, 2005,65(5): 2009-2017.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 2009-2017
    • Sanchez-Perez, L.1    Kottke, T.2    Diaz, R.M.3
  • 24
    • 0032717587 scopus 로고    scopus 로고
    • Genes involved in melanoma: An overview of ink4a and other loci [J]
    • Castellano M, Parmiani G. Genes involved in melanoma: an overview of ink4a and other loci [J]. Melanoma Res, 1999,9(5):421-432.
    • (1999) Melanoma Res , vol.9 , Issue.5 , pp. 421-432
    • Castellano, M.1    Parmiani, G.2
  • 25
    • 33747332544 scopus 로고    scopus 로고
    • Malignant melanoma: Genetics and therapeutics in the genomic era [J]
    • Chin L, Garraway LA, Fisher DE. Malignant melanoma: Genetics and therapeutics in the genomic era [J]. Genes Dev, 2006,20(16):2149-2182.
    • (2006) Genes Dev , vol.20 , Issue.16 , pp. 2149-2182
    • Chin, L.1    Garraway, L.A.2    Fisher, D.E.3
  • 26
    • 65649147543 scopus 로고    scopus 로고
    • Braf (v600e) cooperates with pten loss to induce metastatic melanoma [J]
    • Dankort D, Curley DP, Cartlidge RA, et al. Braf (v600e) cooperates with pten loss to induce metastatic melanoma [J]. Nat Genet, 2009,41 (5):544-552.
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 544-552
    • Dankort, D.1    Curley, D.P.2    Cartlidge, R.A.3
  • 27
    • 77954358935 scopus 로고    scopus 로고
    • A mouse model of melanoma driven by oncogenic kras [J]
    • Milagre C, Dhomen N, Geyer FC, et al. A mouse model of melanoma driven by oncogenic kras [J]. Cancer Res, 2010,70 (13):5549-5557.
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5549-5557
    • Milagre, C.1    Dhomen, N.2    Geyer, F.C.3
  • 28
    • 78049345763 scopus 로고    scopus 로고
    • Somatic p16(ink4a) loss accelerates melanomagenesis [J]
    • Monahan KB, Rozenberg GI, Krishnamurthy J, et al. Somatic p16(ink4a) loss accelerates melanomagenesis [J]. Oncogene, 2010,29(43):5809-5817.
    • (2010) Oncogene , vol.29 , Issue.43 , pp. 5809-5817
    • Monahan, K.B.1    Rozenberg, G.I.2    Krishnamurthy, J.3
  • 29
    • 78649500093 scopus 로고    scopus 로고
    • Cooperative interactions of pten deficiency and ras activation in melanoma metastasis [J]
    • Nogueira C, Kim KH, Sung H, et al. Cooperative interactions of pten deficiency and ras activation in melanoma metastasis [J]. Oncogene, 2010,29(47):6222-6232.
    • (2010) Oncogene , vol.29 , Issue.47 , pp. 6222-6232
    • Nogueira, C.1    Kim, K.H.2    Sung, H.3
  • 30
    • 0030729474 scopus 로고    scopus 로고
    • Cooperative effects of ink4a and ras in melanoma susceptibility in vivo [J]
    • Chin L, Pomerantz J, Polsky D, et al. Cooperative effects of ink4a and ras in melanoma susceptibility in vivo [J]. Genes Dev, 1997,11(21):2822-2834.
    • (1997) Genes Dev , vol.11 , Issue.21 , pp. 2822-2834
    • Chin, L.1    Pomerantz, J.2    Polsky, D.3
  • 31
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead braf and oncogenic ras cooperate to drive tumor progression through craf [J]
    • Heidorn SJ, Milagre C, Whittaker S, et al. Kinase-dead braf and oncogenic ras cooperate to drive tumor progression through craf [J]. Cell, 2010,140(2):209-221.
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3
  • 32
    • 36249026528 scopus 로고    scopus 로고
    • Beta-catenin induces immortalization of melanocytes by suppressing p16ink4a expression and cooperates with n-ras in melanoma development [J]
    • Delmas V, Beermann F, Martinozzi S, et al. Beta-catenin induces immortalization of melanocytes by suppressing p16ink4a expression and cooperates with n-ras in melanoma development [J]. Genes Dev, 2007,21 (22):2923-2935.
    • (2007) Genes Dev , vol.21 , Issue.22 , pp. 2923-2935
    • Delmas, V.1    Beermann, F.2    Martinozzi, S.3
  • 33
    • 78049243108 scopus 로고    scopus 로고
    • Differential roles of the prb and arf/p53 pathways in murine naevus and melanoma genesis [J]
    • Ferguson B, Konrad Muller H, Handoko HY, et al. Differential roles of the prb and arf/p53 pathways in murine naevus and melanoma genesis [J]. Pigment Cell Melanoma Res, 2010,23 (6):771-780.
    • (2010) Pigment Cell Melanoma Res , vol.23 , Issue.6 , pp. 771-780
    • Ferguson, B.1    Konrad Muller, H.2    Handoko, H.Y.3
  • 34
    • 34447569679 scopus 로고    scopus 로고
    • Arf functions as a melanoma tumor suppressor by inducing p53-independent senescence [J]
    • Ha L, Ichikawa T, Anver M, et al. Arf functions as a melanoma tumor suppressor by inducing p53-independent senescence [J]. Proc Natl Acad Sci USA, 2007,104(26):10968-10973.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.26 , pp. 10968-10973
    • Ha, L.1    Ichikawa, T.2    Anver, M.3
  • 35
    • 0037112371 scopus 로고    scopus 로고
    • Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis [J]
    • Recio JA, Noonan FP, Takayama H, et al. Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis [J]. Cancer Res, 2002,62(22):6724-6730.
    • (2002) Cancer Res , vol.62 , Issue.22 , pp. 6724-6730
    • Recio, J.A.1    Noonan, F.P.2    Takayama, H.3
  • 36
    • 75149165632 scopus 로고    scopus 로고
    • Characterization of melanoma cells capable of propagating tumors from a single cell [J]
    • Held MA, Curley DP, Dankort D, et al. Characterization of melanoma cells capable of propagating tumors from a single cell [J]. Cancer Res, 2010,70(1):388-397.
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 388-397
    • Held, M.A.1    Curley, D.P.2    Dankort, D.3
  • 37
    • 0035890354 scopus 로고    scopus 로고
    • Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame [J]
    • Yang J, Luan J, Yu Y, et al. Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame [J]. Cancer Res, 2001,61(22):8150-8157.
    • (2001) Cancer Res , vol.61 , Issue.22 , pp. 8150-8157
    • Yang, J.1    Luan, J.2    Yu, Y.3
  • 38
    • 67349212438 scopus 로고    scopus 로고
    • Melanocytic nevus-like hyperplasia and melanoma in transgenic brafv600e mice [J]
    • Goel VK, Ibrahim N, Jiang G, et al. Melanocytic nevus-like hyperplasia and melanoma in transgenic brafv600e mice [J]. Oncogene, 2009,28(23):2289-2298.
    • (2009) Oncogene , vol.28 , Issue.23 , pp. 2289-2298
    • Goel, V.K.1    Ibrahim, N.2    Jiang, G.3
  • 39
    • 20144375230 scopus 로고    scopus 로고
    • Metastasizing melanoma formation caused by expression of activated n-rasq61k on an ink4a-deficient background [J]
    • Ackermann J, Frutschi M, Kaloulis K, et al. Metastasizing melanoma formation caused by expression of activated n-rasq61k on an ink4a-deficient background [J]. Cancer Res, 2005,65(10):4005-4011.
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4005-4011
    • Ackermann, J.1    Frutschi, M.2    Kaloulis, K.3
  • 40
    • 0034518239 scopus 로고    scopus 로고
    • Ultraviolet radiation induces both full activation of ret kinase and malignant melanocytic tumor promotion in rfp-ret-transgenic mice [J]
    • Kato M, Liu W, Akhand AA, et al. Ultraviolet radiation induces both full activation of ret kinase and malignant melanocytic tumor promotion in rfp-ret-transgenic mice [J]. J Invest Dermatol, 2000,115(6):1157-1158.
    • (2000) J Invest Dermatol , vol.115 , Issue.6 , pp. 1157-1158
    • Kato, M.1    Liu, W.2    Akhand, A.A.3
  • 41
    • 75149129051 scopus 로고    scopus 로고
    • A novel mouse model for de novo melanoma [J]
    • Kumasaka MY, Yajima I, Hossain K, et al. A novel mouse model for de novo melanoma [J]. Cancer Res, 2010,70(1):24-29.
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 24-29
    • Kumasaka, M.Y.1    Yajima, I.2    Hossain, K.3
  • 42
    • 14644425398 scopus 로고    scopus 로고
    • lnterleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma [J]
    • von Felbert V, Cordoba F, Weissenberger J, et al. lnterleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma [J]. Am J Pathol, 2005,166(3):831-841.
    • (2005) Am J Pathol , vol.166 , Issue.3 , pp. 831-841
    • von Felbert, V.1    Cordoba, F.2    Weissenberger, J.3
  • 43
    • 34250831624 scopus 로고    scopus 로고
    • Loss of xeroderma pigmentosum c (xpc) enhances melanoma photocarcinogenesis in ink4a-arf-deficient mice [J]
    • Yang G, Curley D, Bosenberg MW, et al. Loss of xeroderma pigmentosum c (xpc) enhances melanoma photocarcinogenesis in ink4a-arf-deficient mice [J]. Cancer Res, 2007,67(12):5649-5657.
    • (2007) Cancer Res , vol.67 , Issue.12 , pp. 5649-5657
    • Yang, G.1    Curley, D.2    Bosenberg, M.W.3
  • 44
    • 63249105225 scopus 로고    scopus 로고
    • Oncogenic braf induces melanocyte senescence and melanoma in mice [J]
    • Dhomen N, Reis-Filho JS, da Rocha Dias S, et al. Oncogenic braf induces melanocyte senescence and melanoma in mice [J]. Cancer Cell, 2009,15(4):294-303.
    • (2009) Cancer Cell , vol.15 , Issue.4 , pp. 294-303
    • Dhomen, N.1    Reis-Filho, J.S.2    da Rocha Dias, S.3
  • 45
    • 33644797263 scopus 로고    scopus 로고
    • Neonatal ultraviolet radiation exposure is critical for malignant melanoma induction in pigmented tpras transgenic mice [J]
    • Hacker E, Irwin N, Muller HK, et al. Neonatal ultraviolet radiation exposure is critical for malignant melanoma induction in pigmented tpras transgenic mice [J]. J Invest Dermatol, 2005,125(5):1074-1077.
    • (2005) J Invest Dermatol , vol.125 , Issue.5 , pp. 1074-1077
    • Hacker, E.1    Irwin, N.2    Muller, H.K.3
  • 46
    • 33645510413 scopus 로고    scopus 로고
    • Spontaneous and uv radiation-induced multiple metastatic melanomas in cdk4r24c/r24c/tpras mice [J]
    • Hacker E, Muller HK, Irwin N, et al. Spontaneous and uv radiation-induced multiple metastatic melanomas in cdk4r24c/r24c/tpras mice [J]. Cancer Res, 2006,66(6):2946-2952.
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 2946-2952
    • Hacker, E.1    Muller, H.K.2    Irwin, N.3
  • 47
    • 0042785967 scopus 로고    scopus 로고
    • Both products of the mouse ink4a/arf locus suppress melanoma formation in vivo [J]
    • Sharpless NE, Kannan K, Xu J, et al. Both products of the mouse ink4a/arf locus suppress melanoma formation in vivo [J]. Oncogene, 2003,22(32):5055-5059.
    • (2003) Oncogene , vol.22 , Issue.32 , pp. 5055-5059
    • Sharpless, N.E.1    Kannan, K.2    Xu, J.3
  • 48
    • 0037418002 scopus 로고    scopus 로고
    • Components of the rb pathway are critical targets of uv mutagenesis in a murine melanoma model [J]
    • Kannan K, Sharpless NE, Xu J, et al. Components of the rb pathway are critical targets of uv mutagenesis in a murine melanoma model [J]. Proc Natl Acad Sci USA, 2003,100(3): 1221-1225.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.3 , pp. 1221-1225
    • Kannan, K.1    Sharpless, N.E.2    Xu, J.3
  • 49
    • 0034997650 scopus 로고    scopus 로고
    • Dual inactivation of rb and p53 pathways in ras-induced melanomas [J]
    • Bardeesy N, Bastian BC, Hezel A, et al. Dual inactivation of rb and p53 pathways in ras-induced melanomas [J]. Mol Cell Biol, 2001,21(6):2144-2153.
    • (2001) Mol Cell Biol , vol.21 , Issue.6 , pp. 2144-2153
    • Bardeesy, N.1    Bastian, B.C.2    Hezel, A.3
  • 50
    • 0037994016 scopus 로고    scopus 로고
    • Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia [J]
    • Pollock PM, Cohen-Solal K, Sood R, et al. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia [J]. Nat Genet, 2003,34(1):108-112.
    • (2003) Nat Genet , vol.34 , Issue.1 , pp. 108-112
    • Pollock, P.M.1    Cohen-Solal, K.2    Sood, R.3
  • 51
    • 0031894534 scopus 로고    scopus 로고
    • Molecular genetics of familial cutaneous melanoma [J]
    • Haluska FG, Hodi FS. Molecular genetics of familial cutaneous melanoma [J]. J Clin Oncol, 1998,16(2):670-682.
    • (1998) J Clin Oncol , vol.16 , Issue.2 , pp. 670-682
    • Haluska, F.G.1    Hodi, F.S.2
  • 52
    • 0031710479 scopus 로고    scopus 로고
    • The ink4a/arf tumor suppressor: One gene-two products-two pathways [J]
    • Chin L, Pomerantz J, DePinho RA. The ink4a/arf tumor suppressor: One gene-two products-two pathways [J]. Trends Biochem Sci, 1998,23(8):291-296.
    • (1998) Trends Biochem Sci , vol.23 , Issue.8 , pp. 291-296
    • Chin, L.1    Pomerantz, J.2    Depinho, R.A.3
  • 53
    • 0033588882 scopus 로고    scopus 로고
    • The ink4 family of cell cycle inhibitors in cancer [J]
    • Roussel MF. The ink4 family of cell cycle inhibitors in cancer [J]. Oncogene, 1999,18(38):5311-5317.
    • (1999) Oncogene , vol.18 , Issue.38 , pp. 5311-5317
    • Roussel, M.F.1
  • 54
    • 0029993450 scopus 로고    scopus 로고
    • Role of the ink4a locus in tumor suppression and cell mortality [J]
    • Serrano M, Lee H, Chin L, et al. Role of the ink4a locus in tumor suppression and cell mortality [J]. Cell, 1996,85(1):27-37.
    • (1996) Cell , vol.85 , Issue.1 , pp. 27-37
    • Serrano, M.1    Lee, H.2    Chin, L.3
  • 55
    • 0029587551 scopus 로고
    • Alternative reading frames of the ink4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest [J]
    • Quelle DE, Zindy F, Ashmun RA, et al. Alternative reading frames of the ink4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest [J]. Cell, 1995,83(6):993-1000.
    • (1995) Cell , vol.83 , Issue.6 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3
  • 56
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse ink4a locus mediated by the alternative reading frame product p19arf [J]
    • Kamijo T, Zindy F, Roussel MF, et al. Tumor suppression at the mouse ink4a locus mediated by the alternative reading frame product p19arf [J]. Cell, 1997,91 (5):649-659.
    • (1997) Cell , vol.91 , Issue.5 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3
  • 57
    • 0032549711 scopus 로고    scopus 로고
    • Arf promotes mdm2 degradation and stabilizes p53: Arf-ink4a locus deletion impairs both the rb and p53 tumor suppression pathways [J]
    • Zhang Y, Xiong Y, Yarbrough WG. Arf promotes mdm2 degradation and stabilizes p53: Arf-ink4a locus deletion impairs both the rb and p53 tumor suppression pathways [J]. Cell, 1998,92(6):725-734.
    • (1998) Cell , vol.92 , Issue.6 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 58
    • 0032530046 scopus 로고    scopus 로고
    • Molecular events in melanoma development and progression [J]
    • Meier F, Satyamoorthy K, Nesbit M, et al. Molecular events in melanoma development and progression [J]. Front Biosci, 1998,3(D):1005-1010.
    • (1998) Front Biosci , vol.3 , Issue.D , pp. 1005-1010
    • Meier, F.1    Satyamoorthy, K.2    Nesbit, M.3
  • 59
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through map kinase cascades [M]
    • Vande Woude GF, Klein G, eds, San Diego: Academic Press
    • Lewis TS, Shapiro PS, Ahn NG. Signal transduction through map kinase cascades [M]. Vande Woude GF, Klein G, eds. Advances in cancer research. San Diego: Academic Press, 1998:49-139.
    • (1998) Advances In Cancer Research , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 60
    • 0025285159 scopus 로고
    • Ras oncogenes: Their role in neoplasia [J]
    • Barbacid M. Ras oncogenes: their role in neoplasia [J]. Eur J Clin Invest, 1990,20(3):225-235.
    • (1990) Eur J Clin Invest , vol.20 , Issue.3 , pp. 225-235
    • Barbacid, M.1
  • 61
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the braf gene in human cancer [J]
    • Davies H, Bignell GR, Cox C, et al. Mutations of the braf gene in human cancer [J]. Nature, 2002,417(6892):949-954.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 62
    • 0033614962 scopus 로고    scopus 로고
    • Essential role for oncogenic ras in tumour maintenance [J]
    • Chin L, Tarn A, Pomerantz J, et al. Essential role for oncogenic ras in tumour maintenance [J]. Nature, 1999,400(6743):468-472.
    • (1999) Nature , vol.400 , Issue.6743 , pp. 468-472
    • Chin, L.1    Tarn, A.2    Pomerantz, J.3
  • 64
    • 0031704432 scopus 로고    scopus 로고
    • Incidence, risk factors and prevention of melanoma [J]
    • MacKie RM. Incidence, risk factors and prevention of melanoma [J]. Eur J Cancer, 1998,34(Suppl 3):S3-S6.
    • (1998) Eur J Cancer , vol.34 , Issue.SUPPL. 3
    • Mackie, R.M.1
  • 65
    • 0035144754 scopus 로고    scopus 로고
    • Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies [J]
    • Whiteman DC, Whiteman CA, Green AC. Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies [J]. Cancer Causes Control, 2001,12(1): 69-82.
    • (2001) Cancer Causes Control , vol.12 , Issue.1 , pp. 69-82
    • Whiteman, D.C.1    Whiteman, C.A.2    Green, A.C.3
  • 66
    • 0035921950 scopus 로고    scopus 로고
    • Neonatal sunburn and melanoma in mice [J]
    • Noonan FP, Recio JA, Takayama H, et al. Neonatal sunburn and melanoma in mice [J]. Nature, 2001,413(6853):271-272.
    • (2001) Nature , vol.413 , Issue.6853 , pp. 271-272
    • Noonan, F.P.1    Recio, J.A.2    Takayama, H.3
  • 67
    • 0034660887 scopus 로고    scopus 로고
    • Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice [J]
    • Noonan FP, Otsuka T, Bang S, et al. Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice [J]. Cancer Res, 2000,60(14):3738-3743.
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3738-3743
    • Noonan, F.P.1    Otsuka, T.2    Bang, S.3
  • 68
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis [J]
    • Fearon E, Vogelstein B. A genetic model for colorectal tumorigenesis [J]. Cell, 1990,61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.1    Vogelstein, B.2
  • 69
    • 0032102650 scopus 로고    scopus 로고
    • Jacks T. Tumor suppressor mutations in mice: The next generation [J]
    • McClatchey Al, Jacks T. Tumor suppressor mutations in mice: The next generation [J]. Curr Opin Genet Dev, 1998,8(3):304-310.
    • (1998) Curr Opin Genet Dev , vol.8 , Issue.3 , pp. 304-310
    • Al, M.1
  • 70
    • 0034104182 scopus 로고    scopus 로고
    • Animal models of melanoma: Recent advances and future prospects [J]
    • Bardeesy N, Wong KK, DePinho RA, et al. Animal models of melanoma: Recent advances and future prospects [J]. Adv Cancer Res, 2000,79:123-156.
    • (2000) Adv Cancer Res , vol.79 , pp. 123-156
    • Bardeesy, N.1    Wong, K.K.2    Depinho, R.A.3
  • 71
    • 0028071115 scopus 로고
    • Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter [J]
    • Furth PA, St Onge L, Boger H, et al. Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter [J]. Proc Natl Acad Sci USA, 1994,91(20):9302-9306.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.20 , pp. 9302-9306
    • Furth, P.A.1    St Onge, L.2    Boger, H.3
  • 72
    • 0028027484 scopus 로고
    • Inducible gene expression systems for higher eukaryotic cells [J]
    • Gossen M, Bonin AL, Freundlieb S, et al. Inducible gene expression systems for higher eukaryotic cells [J]. Curr Opin Biotechnol, 1994,5(5):516-520.
    • (1994) Curr Opin Biotechnol , vol.5 , Issue.5 , pp. 516-520
    • Gossen, M.1    Bonin, A.L.2    Freundlieb, S.3
  • 73
    • 0029021083 scopus 로고
    • A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice [J]
    • Shockett P, Difilippantonio M, Hellman N, et al. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice [J].Proc Natl Acad Sci USA, 1995,92(14):6522-6526.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.14 , pp. 6522-6526
    • Shockett, P.1    Difilippantonio, M.2    Hellman, N.3
  • 74
    • 0032954092 scopus 로고    scopus 로고
    • Insights into cancer from transgenic mouse models [J]
    • Macleod KF, Jacks T. Insights into cancer from transgenic mouse models [J]. J Pathol, 1999,187(1):43-60.
    • (1999) J Pathol , vol.187 , Issue.1 , pp. 43-60
    • Macleod, K.F.1    Jacks, T.2
  • 75
    • 0027968207 scopus 로고
    • Extensive contribution of rb-deficient cells to adult chimeric mice with limited histopathological consequences [J]
    • Williams BO, Schmitt EM, Remington L, et al. Extensive contribution of rb-deficient cells to adult chimeric mice with limited histopathological consequences [J]. Embo J, 1994,13 (18):4251-4259.
    • (1994) Embo J , vol.13 , Issue.18 , pp. 4251-4259
    • Williams, B.O.1    Schmitt, E.M.2    Remington, L.3
  • 77
    • 0027421873 scopus 로고
    • Receptor for subgroup a rous sarcoma virus is related to the low density lipoprotein receptor [J]
    • Bates P, Young J, Varmus H. Receptor for subgroup a rous sarcoma virus is related to the low density lipoprotein receptor [J]. Cell, 1993,74:1043-1051.
    • (1993) Cell , vol.74 , pp. 1043-1051
    • Bates, P.1    Young, J.2    Varmus, H.3
  • 78
    • 0027461928 scopus 로고
    • Isolation of a chicken gene that confers susceptibility to infection by subgroup a avian leukosis and sarcoma viruses [J]
    • Young J, Bates P, Varmus H. Isolation of a chicken gene that confers susceptibility to infection by subgroup a avian leukosis and sarcoma viruses [J]. Journal of Virology, 1993,67(4):1811-1816.
    • (1993) Journal of Virology , vol.67 , Issue.4 , pp. 1811-1816
    • Young, J.1    Bates, P.2    Varmus, H.3
  • 79
    • 0028117777 scopus 로고
    • A system for tissue-specific gene targeting: Transgenic mice susceptible to subgroup a avian leukosis virus-based retroviral vectors [J]
    • Federspiel MJ, Bates P, Young JA, et al. A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup a avian leukosis virus-based retroviral vectors [J]. Proc Natl Acad Sci USA, 1994,91(23):11241-11245.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.23 , pp. 11241-11245
    • Federspiel, M.J.1    Bates, P.2    Young, J.A.3
  • 80
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption of Gi cell-cycle arrest pathways to induce glioma-like lesions in mice [J]
    • Holland EC, Hively WP, DePinho RA, et al. A constitutively active epidermal growth factor receptor cooperates with disruption of Gi cell-cycle arrest pathways to induce glioma-like lesions in mice [J]. Genes Dev, 1998,12(23):3675-3685.
    • (1998) Genes Dev , vol.12 , Issue.23 , pp. 3675-3685
    • Holland, E.C.1    Hively, W.P.2    Depinho, R.A.3
  • 81
    • 0033046971 scopus 로고    scopus 로고
    • A model for studying megakaryocyte development and biology [J]
    • Murphy GJ, Leavitt AD. A model for studying megakaryocyte development and biology [J]. Proc Natl Acad Sci USA, 1999,96(6):3065-3070.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.6 , pp. 3065-3070
    • Murphy, G.J.1    Leavitt, A.D.2
  • 82
    • 0027260333 scopus 로고
    • A new defective retroviral vector system based on the bryan strain of rous sarcoma virus [J]
    • Boerkoel CF, Federspiel MJ, Salter DW, et al. A new defective retroviral vector system based on the bryan strain of rous sarcoma virus [J]. Virology, 1993,195(2):669-679.
    • (1993) Virology , vol.195 , Issue.2 , pp. 669-679
    • Boerkoel, C.F.1    Federspiel, M.J.2    Salter, D.W.3
  • 83
    • 0032169950 scopus 로고    scopus 로고
    • The df-1 chicken fibroblast cell line: Transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses [J]
    • Himly M, Foster DN, Bottoli I, et al. The df-1 chicken fibroblast cell line: transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses [J]. Virology, 1998,248(2):295-304.
    • (1998) Virology , vol.248 , Issue.2 , pp. 295-304
    • Himly, M.1    Foster, D.N.2    Bottoli, I.3
  • 84
    • 0032168060 scopus 로고    scopus 로고
    • The ev-o-derived cell line df-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors [J]
    • Schaefer-Klein J, Givol I, Barsov EV, et al. The ev-o-derived cell line df-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors [J]. Virology, 1998,248(2):305-311.
    • (1998) Virology , vol.248 , Issue.2 , pp. 305-311
    • Schaefer-Klein, J.1    Givol, I.2    Barsov, E.V.3
  • 85
    • 0031717379 scopus 로고    scopus 로고
    • Inducible gene targeting in mice using the cre/lox system [J]
    • Sauer B. Inducible gene targeting in mice using the cre/lox system [J]. Methods, 1998,14(4):381-392.
    • (1998) Methods , vol.14 , Issue.4 , pp. 381-392
    • Sauer, B.1
  • 86
    • 48249128709 scopus 로고    scopus 로고
    • A cre-loxp-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors [J]
    • Seidler B, Schmidt A, Mayr U, et al. A cre-loxp-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors [J]. Proc Natl Acad Sci USA, 2008,105(29):10137-10142.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.29 , pp. 10137-10142
    • Seidler, B.1    Schmidt, A.2    Mayr, U.3
  • 87
    • 0033588840 scopus 로고    scopus 로고
    • Development of a flexible and specific gene delivery system for production of murine tumor models [J]
    • Fisher GH, Orsulic S, Holland E, et al. Development of a flexible and specific gene delivery system for production of murine tumor models [J]. Oncogene, 1999,18(38):5253-5260.
    • (1999) Oncogene , vol.18 , Issue.38 , pp. 5253-5260
    • Fisher, G.H.1    Orsulic, S.2    Holland, E.3
  • 88
    • 0036802652 scopus 로고    scopus 로고
    • An rcas-tva-based approach to designer mouse models [J]
    • Orsulic S. An rcas-tva-based approach to designer mouse models [J]. Mamm Genome, 2002,13(10):543-547.
    • (2002) Mamm Genome , vol.13 , Issue.10 , pp. 543-547
    • Orsulic, S.1
  • 89
    • 0034730204 scopus 로고    scopus 로고
    • Neural crest-directed gene transfer demonstrates wntl role in melanocyte expansion and differentiation during mouse development [J]
    • Dunn KJ, Williams BO, Li Y, et al. Neural crest-directed gene transfer demonstrates wntl role in melanocyte expansion and differentiation during mouse development [J]. Proc Natl Acad Sci USA, 2000,97(18):10050-10055.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.18 , pp. 10050-10055
    • Dunn, K.J.1    Williams, B.O.2    Li, Y.3
  • 90
    • 19544365754 scopus 로고    scopus 로고
    • Wnt1 and wnt3a promote expansion of melanocytes through distinct modes of action [J]
    • Dunn KJ, Brady M, Ochsenbauer-Jambor C, et al. Wnt1 and wnt3a promote expansion of melanocytes through distinct modes of action [J]. Pigment Cell Res, 2005,18(3):167-180.
    • (2005) Pigment Cell Res , vol.18 , Issue.3 , pp. 167-180
    • Dunn, K.J.1    Brady, M.2    Ochsenbauer-Jambor, C.3
  • 91
    • 0036720668 scopus 로고    scopus 로고
    • Functional studies of the kidney of living animals using multicolor two-photon microscopy [J]
    • Dunn KW, Sandoval RM, Kelly KJ, et al. Functional studies of the kidney of living animals using multicolor two-photon microscopy [J]. Am J Physiol Cell Physiol, 2002,283(3):C905-C916.
    • (2002) Am J Physiol Cell Physiol , vol.283 , Issue.3
    • Dunn, K.W.1    Sandoval, R.M.2    Kelly, K.J.3
  • 92
    • 0026446976 scopus 로고
    • Trp-2/dct, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor [J]
    • Steel KP, Davidson DR, Jackson IJ. Trp-2/dct, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor [J]. Development, 1992,115(4): 1111-1119.
    • (1992) Development , vol.115 , Issue.4 , pp. 1111-1119
    • Steel, K.P.1    Davidson, D.R.2    Jackson, I.J.3
  • 93
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering rnas in mammalian cells [J]
    • Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering rnas in mammalian cells [J]. Science, 2002,296(5567):550-553.
    • (2002) Science , vol.296 , Issue.5567 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 94
    • 0037370309 scopus 로고    scopus 로고
    • An epi-allelic series of p53 hypomorphs created by stable rnai produces distinct tumor phenotypes in vivo [J]
    • Hemann MT, Fridman JS, Zilfou JT, et al. An epi-allelic series of p53 hypomorphs created by stable rnai produces distinct tumor phenotypes in vivo [J]. Nat Genet, 2003,33(3):396-400.
    • (2003) Nat Genet , vol.33 , Issue.3 , pp. 396-400
    • Hemann, M.T.1    Fridman, J.S.2    Zilfou, J.T.3
  • 95
    • 0037370498 scopus 로고    scopus 로고
    • A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by rna interference [J]
    • Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by rna interference [J]. Nat Genet, 2003,33(3):401-406.
    • (2003) Nat Genet , vol.33 , Issue.3 , pp. 401-406
    • Rubinson, D.A.1    Dillon, C.P.2    Kwiatkowski, A.V.3
  • 96
    • 4344570338 scopus 로고    scopus 로고
    • Delivery of short hairpin rna sequences by using a replication-competent avian retroviral vector [J]
    • Bromberg-White JL, Webb CP, Patacsil VS, et al. Delivery of short hairpin rna sequences by using a replication-competent avian retroviral vector [J]. J Virol, 2004,78(9):4914-4916.
    • (2004) J Virol , vol.78 , Issue.9 , pp. 4914-4916
    • Bromberg-White, J.L.1    Webb, C.P.2    Patacsil, V.S.3
  • 97
    • 66149173789 scopus 로고    scopus 로고
    • The pten-regulating microrna mir-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo [J]
    • Huse JT, Brennan C, Hambardzumyan D, et al. The pten-regulating microrna mir-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo [J]. Genes Dev, 2009,23 (11):1327-1337.
    • (2009) Genes Dev , vol.23 , Issue.11 , pp. 1327-1337
    • Huse, J.T.1    Brennan, C.2    Hambardzumyan, D.3
  • 98
    • 20444376156 scopus 로고    scopus 로고
    • Essential role of beta-catenin in postnatal bone acquisition [J]
    • Holmen SL, Zylstra CR, Mukherjee A, et al. Essential role of beta-catenin in postnatal bone acquisition [J]. J Biol Chem, 2005,280(22):21162-21168.
    • (2005) J Biol Chem , vol.280 , Issue.22 , pp. 21162-21168
    • Holmen, S.L.1    Zylstra, C.R.2    Mukherjee, A.3
  • 99
    • 0029763587 scopus 로고    scopus 로고
    • Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice [J]
    • Kistner A, Gossen M, Zimmermann F, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice [J]. Proc Natl Acad Sci USA, 1996,93(20): 10933-10938.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.20 , pp. 10933-10938
    • Kistner, A.1    Gossen, M.2    Zimmermann, F.3
  • 100
    • 0034855638 scopus 로고    scopus 로고
    • Development of an avian leukosis-sarcoma virus subgroup a pseudotyped lentiviral vector [J]
    • Lewis BC, Chinnasamy N, Morgan RA, et al. Development of an avian leukosis-sarcoma virus subgroup a pseudotyped lentiviral vector [J]. J Virol, 2001,75(19):9339-9344.
    • (2001) J Virol , vol.75 , Issue.19 , pp. 9339-9344
    • Lewis, B.C.1    Chinnasamy, N.2    Morgan, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.