Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice

Pigment Cell and Melanoma Research

Volumn 23, Issue 4, 2010, Pages 531-541

  Vanbrocklin, Matthew W ^a   Robinson, James P ^a   Lastwika, Kristin J ^a   Khoury, Joseph D ^a   Holmen, Sheri L ^a  

^a NEVADA CANCER INSTITUTE   (United States)

Author keywords

Ink4a Arf; melanocytes; melanoma; Ras; Somatic cell gene delivery

Indexed keywords

ASPARAGINASE; CRE RECOMBINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DOPACHROME TAUTOMERASE; PROTEIN NRAS Q61R; RAS PROTEIN; TVA RECEPTOR; UNCLASSIFIED DRUG; VIRUS RECEPTOR; BACTERIOPHAGE RECEPTOR; INTEGRASE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; MELANOCYTE; MELANOMA; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; RETROVIRUS; ANIMAL; DISEASE MODEL; GENE TRANSFER; GENETICS; METABOLISM; MOUSE STRAIN; PATHOLOGY;

MUS;

ANIMALS; ATTACHMENT SITES, MICROBIOLOGICAL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; INTEGRASES; MELANOCYTES; MELANOMA; MICE; MICE, INBRED STRAINS; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 77954728876     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2010.00717.x     Document Type: Article

References (43)

1. Ackermann, J., Frutschi, M., Kaloulis, K., Mckee, T., Trumpp, A. Beermann, F. (2005). Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 65, 4005 4011.
2. Aguirre, A.J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D.A., Horner, J., Redston, M.S. Depinho, R.A. (2003). Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112 3126.
3. Ahmed, I. (1997). Malignant melanoma: prognostic indicators. Mayo Clin. Proc. 72, 356 361.
4. Barbacid, M. (1990). Ras oncogenes: their role in neoplasia. Eur. J. Clin. Invest. 20, 225 235.
5. Bromberg-White, J.L., Webb, C.P., Patacsil, V.S., Miranti, C.K., Williams, B.O. Holmen, S.L. (2004). Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector. J. Virol. 78, 4914 4916.
6. Broome Powell, M., Gause, P.R., Hyman, P., Gregus, J., Lluria-Prevatt, M., Nagle, R. Bowden, G.T. (1999). Induction of melanoma in TPras transgenic mice. Carcinogenesis 20, 1747 1753.
7. Castellano, M. Parmiani, G. (1999). Genes involved in melanoma: an overview of INK4a and other loci. Melanoma Res. 9, 421 432.
8. Chin, L., Pomerantz, J., Polsky, D., Jacobson, M., Cohen, C., Cordon-Cardo, C., Horner II., J.W. Depinho, R.A. (1997). Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 11, 2822 2834.
9. Chin, L., Tam, A., Pomerantz, J. et al. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468 472.
10. Chin, L., Garraway, L.A. Fisher, D.E. (2006). Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev. 20, 2149 2182.
11. Dankort, D., Curley, D.P., Cartlidge, R.A., Nelson, B., Karnezis, A.N., Damsky, W.E. Jr., You, M.J., Depinho, R.A., Mcmahon, M. Bosenberg, M. (2009). Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat. Genet. 41, 544 552.
12. Davies, H., Bignell, G.R., Cox, C. et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417, 949 954.
13. Dhomen, N., Reis-Filho, J.S., Da Rocha Dias, S., Hayward, R., Savage, K., Delmas, V., Larue, L., Pritchard, C. Marais, R. (2009). Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell 15, 294 303.
14. Du, Z., Podsypanina, K., Huang, S. et al. (2006). Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc. Natl. Acad. Sci. U S A 103, 17396 17401.
15. Dunn, K.J., Williams, B.O., Li, Y. Pavan, W.J. (2000). Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc. Natl. Acad. Sci. U S A 97, 10050 10055.
16. Dunn, K.J., Incao, A., Watkins-Chow, D., Li, Y. Pavan, W.J. (2001). In utero complementation of a neural crest-derived melanocyte defect using cell directed gene transfer. Genesis 30, 70 76.
17. Dunn, K.J., Brady, M., Ochsenbauer-Jambor, C., Snyder, S., Incao, A. Pavan, W.J. (2005). WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action. Pigment Cell Res. 18, 167 180.
18. Federspiel, M. Hughes, S 1997) Retroviral gene delivery. In Methods in Cell Biology: Methods in Muscle Biology, Emerson, C. Sweeney, H., eds
19. Federspiel, M.J., Bates, P., Young, J.A., Varmus, H.E. Hughes, S.H. (1994). A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors. Proc. Natl. Acad. Sci. USA 91, 11241 11245.
20. Fisher, G.H., Orsulic, S., Holland, E., Hively, W.P., Li, Y., Lewis, B.C., Williams, B.O. Varmus, H.E. (1999). Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene 18, 5253 5260.
21. Giehl, K. (2005). Oncogenic Ras in tumour progression and metastasis. Biol. Chem. 386, 193 205.
22. Goel, V.K., Ibrahim, N., Jiang, G., Singhal, M., Fee, S., Flotte, T., Westmoreland, S., Haluska, F.S., Hinds, P.W. Haluska, F.G. (2009). Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene 28, 2289 2298.
23. Haluska, F.G. Hodi, F.S. (1998). Molecular genetics of familial cutaneous melanoma. J. Clin. Oncol. 16, 670 682.
24. Hoffman, R.M. (2007). The potential of nestin-expressing hair follicle stem cells in regenerative medicine. Expert. Opin. Biol. Ther. 7, 289 291.
25. Holmen, S.L. Williams, B.O. (2005). Essential role for Ras signaling in glioblastoma maintenance. Cancer Res. 65, 8250 8255.
26. Holmen, S.L., Salter, D.W., Payne, W.S., Dodgson, J.B., Hughes, S.H. Federspiel, M.J. (1999). Soluble forms of the subgroup A avian leukosis virus [ALV(A)] receptor Tva significantly inhibit ALV(A) infection in vitro and in vivo. J. Virol. 73, 10051 10060.
27. Inoue-Narita, T., Hamada, K., Sasaki, T. et al. (2008). Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res. 68, 5760 5768.
28. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J. Thun, M.J. (2009). Cancer statistics, 2009. CA Cancer J. Clin. 59, 225 249.
29. Lewis, T. S., Shapiro, P. S. Ahn, N. G 1998) Signal transduction through MAP kinase cascades. In Advances in Cancer Research, Vande Woude, G. F. Klein, G., eds
30. Meier, F., Satyamoorthy, K., Nesbit, M., Hsu, M.Y., Schittek, B., Garbe, C. Herlyn, M. (1998). Molecular events in melanoma development and progression. Front. Biosci. 3, D1005 D1010.
31. Ohsie, S.J., Sarantopoulos, G.P., Cochran, A.J. Binder, S.W. (2008). Immunohistochemical characteristics of melanoma. J. Cutan. Pathol. 35, 433 444.
32. Pao, W., Klimstra, D.S., Fisher, G.H. Varmus, H.E. (2003). Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance. Proc. Natl. Acad. Sci. U S A 100, 8764 8769.
33. Pho, L., Grossman, D. Leachman, S.A. (2006). Melanoma genetics: a review of genetic factors and clinical phenotypes in familial melanoma. Curr. Opin. Oncol. 18, 73 179.
34. Reifenberger, J., Knobbe, C.B., Sterzinger, A.A., Blaschke, B., Schulte, K.W., Ruzicka, T. Reifenberger, G. (2004). Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. Int. J. Cancer 109, 377 384.
35. Robinson, J.P., Vanbrocklin, M.W., Guilbeault, A.R., Signorelli, D.L., Brandner, S. Holmen, S.L. (2010). Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation. Oncogene 29, 335 344.
36. Schaefer-Klein, J., Givol, I., Barsov, E.V., Whitcomb, J.M., Vanbrocklin, M., Foster, D.N., Federspiel, M.J. Hughes, S.H. (1998). The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vectors. Virology 248, 305 311.
37. Seidler, B., Schmidt, A., Mayr, U., Nakhai, H., Schmid, R.M., Schneider, G. Saur, D. (2008). A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc. Natl. Acad. Sci. U S A 105, 10137 10142.
38. Shukla, V.K., Hughes, D.C., Hughes, L.E., Mccormick, F. Padua, R.A. (1989). ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development. Oncogene Res 5, 121 127.
39. Smith, E.J., Fadly, A. Okazaki, W. (1979). An enzyme-linked immunosorbent assay for detecting avian leukosis-sarcoma viruses. Avian Dis. 23, 698 707.
40. Steel, K.P., Davidson, D.R. Jackson, I.J. (1992). TRP-2/DCT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 115, 1111 1119.
41. Tobin, D.J., Hagen, E., Botchkarev, V.A. Paus, R. (1998). Do hair bulb melanocytes undergo apoptosis during hair follicle regression (catagen)? J. Invest. Dermatol. 111, 941 947.
42. Whitwam, T., Vanbrocklin, M.W., Russo, M.E., Haak, P.T., Bilgili, D., Resau, J.H., Koo, H.M. Holmen, S.L. (2007). Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene 26, 4563 4570.
43. Zhao, S. Overbeek, P.A. (1999). Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev. Biol. 216, 154 163.