Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

Nature Genetics

Volumn 34, Issue 1, 2003, Pages 108-112

  Pollock, Pamela M ^a   Cohen Solal, Karine ^b   Sood, Raman ^a   Namkoong, Jin ^b   Martino, Jeffrey J ^b   Koganti, Aruna ^b   Zhu, Hua ^b   Robbins, Christiane ^a   Makalowska, Izabela ^a   Shin, Seung Shick ^b   Marin, Yari ^b   Roberts, Kathleen G ^b   Yudt, Laura M ^a   Chen, Amy ^a   Cheng, Jun ^a   Incao, Arturo ^a   Pinkett, Heather W ^a   Graham, Christopher L ^a   Dunn, Karen ^a   Crespo Carbone, Steven M ^b   Mackason, Kerine R ^b   Ryan, Kevin B ^b   Sinsimer, Daniel ^b   Goydos, James ^c,d   Reuhl, Kenneth R ^b   Eckhaus, Michael ^e   Meltzer, Paul S ^a   Pavan, William J ^a   Trent, Jeffrey M ^a   Chen, Suzie ^b,d   more..

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE STRUCTURE; GENETIC CODE; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MOUSE; NEVUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUMOR BIOPSY;

ANIMALS; DNA, COMPLEMENTARY; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; MELANOMA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TRANSFECTION;

ANIMALIA; INSERTION SEQUENCES; MUS MUSCULUS;

EID: 0037994016     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1148     Document Type: Article

References (20)

1. Chen, S., Zhu, H., Wetzel, W.J. & Philbert, M.A. Spontaneous melanocytosis in transgenic mice. J. Invest. Dermatol. 106, 1145-1150 (1996).
2. Zhu, H. et al. Development of heritable melanoma in transgenic mice. J. Invest. Dermatol. 110, 247-252 (1998).
3. Colon-Teicher, L. et al. Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 21, 2223-2228 (1993).
4. Budd, P.S. & Jackson, I.J. Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty alleles. Genomics 29, 35-43 (1995).
5. Mackenzie, M.A., Jordan, S.A., Budd, P.S. & Jackson, I.J. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev. Biol. 192, 99-107 (1997).
6. Reedy, M.V., Parichy, D.M., Erickson, C.A., Mason, K.A. & Frost-Mason, S.K. Regulation of Melanoblast Migration and Differentiation. in The Pigmentary System: Physiology and Pathophysiology (eds. Nordlund, JJ., Boissy, R.E., Hearing, V.J., King, R.A. & Ortonne, J.P.) (Oxford University Press, New York, 1998).
7. Skerry, T.M. & Genever, P.G. Glutamate signalling in non-neuronal tissues. Trends Pharmacol. Sci. 22, 174-181 (2001).
8. Hermans, E. & Challiss, R.A. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem. J. 359, 465-484 (2001).
9. Aiba, A. et al. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79, 377-388 (1994).
10. Aiba, A. et al. Reduced hippocampal long-term potentiation and ontext-specific deficit in associative learning in mGluR1 mutant mice. Cell 79, 365-375 (1994).
11. Conquet, F. et al. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372, 237-243 (1994).
12. Dhanasekaran, N., Heasley, L.E. & Johnson, G.L. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr. Rev. 16, 259-270 (1995).
13. Gutkind, J.S. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17, 1331-1342 (1998).
14. Takano, T. et al. Glutamate release promotes growth of malignant gliomas. Nat. Med. 7, 1010-1015 (2001).
15. Rzeski, W., Turski, L. & Ikonomidou, C. Glutamate antagonists limit tumor growth. Proc. Natl. Acad. Sci. USA 98, 6372-6377 (2001).
16. Frati, C. et al. Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes. J. Cell Physiol. 183, 364-372 (2000).
17. Jhappan, C. et al. TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61, 1137-1146 (1990).
18. Zhu, H., Ryan, K. & Chen, S. Cloning of novel splice variants of mouse mGluR1. Brain Res. Mol. Brain Res. 73, 93-103 (1999).
19. Sood, R. et al. Cloning and characterization of a novel gene SHPRH encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from 6q24 region. Genomics (in the press).
20. Zhu, H. et al. Development of early melanocytic lesions in transgenic mice predisposed to melanoma. Pigment Cell Res. 13, 158-164 (2000).