Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway

Archives of Toxicology

Volumn 85, Issue 3, 2011, Pages 209-218

  Chuang, Chi Yuan ^a,c   Chen, Ta Liang ^a,d   Cherng, Yih Giun ^e   Tai, Yu Tyng ^b   Chen, Tyng Guey ^b   Chen, Ruei Ming ^b,f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e Shuang Ho Hospital   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Alveolar epithelial cells; Apoptosis; Intrinsic mechanism; Lipopolysaccharide; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; BACTERIUM LIPOPOLYSACCHARIDE; CASPASE 6; CASPASE 9; CYTOCHROME C; NITRIC OXIDE; PROTEINASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN; CELL STRAIN A549; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL TYPE 2; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; PRIORITY JOURNAL;

ACETYLCYSTEINE; APOPTOSIS; CASPASE 6; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; DNA FRAGMENTATION; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NITRIC OXIDE; PNEUMOCYTES; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES; TIME FACTORS;

NEGIBACTERIA;

EID: 79954415687     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0585-x     Document Type: Article

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