Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function

Drug Metabolism and Disposition

Volumn 37, Issue 1, 2009, Pages 24-31

  Chang, Huai Chia ^a,b   Chen, Ta Liang ^c   Chen, Ruei Ming ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME P450 3A4; F ACTIN; KETAMINE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANESTHESIA; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; DRUG EFFECT; DRUG TRANSFORMATION; ENZYME ACTIVITY; GENE REPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; MICROTUBULE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; CALCIUM; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; CYTOSKELETON; DNA PRIMERS; HUMANS; KETAMINE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 58149463742     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.023325     Document Type: Article

References (40)

1. Adamíková L, Straube A, Schulz L, and Steinberg G(2QQ4) Calcium signaling is involved in dynein-dependent microtubule organization. Mol Biol Cell 15:1969-1980.
2. Adrain C, Duriez PJ, Brumatti G, Delivani P, and Martin SJ (2006) The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics. J Biol Chem 281:8118-8125.
3. Akata T, Izumi K, and Nakashima M (2001) Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries. Anesthesiology 95:452-462.
4. Bourgoin A, Albanèse J, Wereszczynski N, Charbit M, Vialet R, and Martin C (2003) Safety of sedation with ketamine in severe head injury patients: comparison with sufentanil. Crit Care Med 31:711-717.
5. Canton DA and Litchfield DW (2006) The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cell Signal 18:267-275.
6. Chan WH, Chen TL, Chen RM, Sun WZ, and Ueng TH (2006) Propofol metabolism is enhanced after repetitive ketamine administration in rats: the role of cytochrome P-450 2B induction. Br J Anaesth 97:351-358.
7. Chan WH, Sun WZ, and Ueng TH (2005) Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. J Toxicol Environ Health A 68:1581-1597.
8. Chang CC, Liao YS, Lin YL, and Chen RM (2006) Nitric oxide protects osteoblasts from oxidative stress-induced apoptotic insults via a mitochondria-dependent mechanism. J Orthop Res 24:1917-1925.
9. Chang Y, Chen TL, Sheu JR, and Chen RM (2005) Suppressive effects of ketamine on macrophage functions. Toxicol Appi Pharmacol 204:27-35.
10. Chen RM, Chen TL, Lin YL, Chen TG, and Tai YT (2005) Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells through down-regulating endothelial nitric oxide syuthase expression and intracellular calcium levels. Crit Care Med 33:1044-1049.
11. Chen RM, Chou MW, and Ueng TH (2000) Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene. Toxicol Lett 117:69-77.
12. Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR, and Chen TL (2003) Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. Anesthesiology 98:1178-1185.
13. Cherng YG, Chang HC, Lin YL, Kuo ML, Chiu WT, and Chen RM (2008) Apoptotic insults to human chondrocytes induced by nitric oxide are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1, and Bax-mitochondria-mediated caspase activation. J Orthop Res 26:1018-1026.
14. Cook DJ, Carton EG, and Housmans PR (1991) Mechanism of the positive inotropic effect of ketamine in isolated ferret ventricular papillary muscle. Atiesthesiology 74:880-888.
15. Domino EF, Zsigmond EK, Domino LE, Domino KE, Kothary SP, and Domino SE (1982) Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentographic assay. Anesth Analg 61:87-92.
16. DvorákZ, Ulrichova J, and Modriansky M (2005) Role of microtubules network in CYP genes expression. Curr Drug Metab 6:545-552.
17. Fache S, Dalous J, Engelund M, Hansen C, Chamaraux F, Fourcade B, Satre M, Devreotes P, and Bruckert F (2005) Calcium mobilization stimulates Dictyostelium discoideuin shear-flowinduced cell motility. J Cell Sci 118:3445-3447.
18. Fleming I and Busse R (1999) Signal transduction of eNOS activation. Cardiovasc Res 43:532-541.
19. Gourlay CW and Ayscough KR (2005) The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol 6:583-589.
20. Grant IS, Nimmo WS, McNicol LR, and Clements JA (1983) Ketamine disposition in children and adults. Br J Anaesth 55:1107-1110.
21. Hijazi Y and Boulieu R (2002) Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos 30:853-858.
22. Hill TL (1981) Microfilament or microtubule assembly or disassembly against a force. Proc Natl Acad Sci USA 78:5613-5617.
23. Martínez-JiménezCP, Jover R, Donato MT, Castell JV, and Gómez-Lechón MJ (2007) Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drag Metab 8:185-194.
24. Meneguz A, Fortuna S, Lorenzini P, and Volpe MT (1999) Influence of urethane and ketamine on rat hepatic cytochrome P450 in vivo. Exp Toxicol Pathol 51:392-396.
25. Molitoris BA, Dahl R, and Hosford M (1996) Cellular ATP depletion induces disruption of the spectrin cytoskeletal network. Am J Physiol 271:F790-F798.
26. Nash T (1953) The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem J 55:416-421.
27. Nishimura Y, Romer LH, and Lemasters JJ (1998) Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine. Hepatology 27:1039-1049.
28. Pallone TL, Silldorff EP, and Cheung JY (1998) Response of isolated rat descending vasa recta to bradykinin. Am J Physiol 274:H752-H759.
29. Papucci L, Schiavone N, Witort E, Donnini M, Lapucci A, Tempestini A, Formigli L, Zecchi-Orlandini S, Orlandini G, Carella G, et al. (2003) Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 278:28220- 28228.
30. Ready S, Ozgur K, Lu M, Chang W, Mohan SR, Kumar CC, and Ruley HE (1990) Structure of the human smooth muscle α-actin gene. J Biol Chem 265:1683-1687.
31. Suurna MV, Ashworth SL, Hosford M, Sandoval RM, Wean SE, Shah BM, Bamburg JR, and Molitoris BA (2006) Cofilin mediates ATP depletion-induced endothelial cell actin alterations. Am J Physiol Renal Physiol 290:F1398- F1407.
32. Takadera T, Ishida A, and Ohyashiki T (2006) Ketamine-induced apoptosis in cultured rat cortical neurons. Toxicol Appl Pharmacol 210:100-107.
33. Thai H, Castellano L, Juneman E, Phan H, Do R, Gaballa MA, and Goldman S (2006) Pretreatment with angiotensin receptor blockade prevents left ventricular dysfunction and blunts left ventricular remodeling associated with acute myocardial infarction. Circulation 114:1933-1939.
34. Wang RW, Newton DJ, Scheri TD, and Lu AY (1997) Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis. Drug Metab Dispos 25:502-507.
35. Weigand MA, Schmidt H, Zhao Q, Plaschke K, Martin E, and Bardenheuer HJ (2000) Ketamine modulates the stimulated adhesion molecule expression on human neutrophils in vitro. Anesth Analg 90:206-212.
36. White PF, Way WL, and Trevor AJ (1982) Ketamine: its pharmacology and therapeutic uses. Anesthesiology 56:119-136.
37. Wu GJ, Chen TG, Chang HC, Chiu WT, Chang CC, and Chen RM (2007) Nitric oxide from both exogenous and endogenous sources activates mitochondria- dependent events and induces insults to human chondrocytes. J Cell Biochem 101:1520-1531.
38. Wu GJ, Chen TL, Ueng YF, and Chen RM (2008) Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide- stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun n-terminal kinase phosphorylation and activator protein-1 activation. Toxicol Appl Pharmacol 228:105-113.
39. Wu GJ, Tai YT, Chen TL, Lin LL, and Chen RM (2005) Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity thus reducing cellular ATP biosynthesis and migration of macrophages. Ann N Y Acad Sci 1042:168-176.
40. Yayama K, Sugiyama K, Miyagi R, and Okamoto H (2007) Angiotensin- converting enzyme inhibitor enhances liver regeneration following partial hepatectomy: involvement of bradykinin B2 and angiotensin AT1 receptors. Biol Pharm Bull 30:591-594.