Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal

Biological Chemistry

Volumn 392, Issue 5, 2011, Pages 475-481

  Gesing, Adam ^a,b   Bartke, Andrzej ^a   Wang, Feiya ^a   Karbownik Lewinska, Malgorzata ^b,c   Masternak, Michal M ^a,d  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^d INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

apoptosis; caspases; GHRKO mice; kidney; proteins; visceral fat removal

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GROWTH HORMONE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; INTRAABDOMINAL FAT; KIDNEY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SURGICAL TECHNIQUE; VISCERAL FAT REMOVAL;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROMES C; INTRA-ABDOMINAL FAT; KIDNEY; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; RECEPTORS, SOMATOTROPIN;

ANIMALIA; MUS; RATTUS;

EID: 79953869913     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2011.051     Document Type: Article

References (44)

1. Adrain, C. and Martin, S.J. (2001). The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem. Sci. 26, 390-397. (Pubitemid 32530658)
2. Ali, S.M., Wong, V.Y., Kikly, K., Fredrickson, T.A., Keller, P.M., DeWolf, Jr. W.E., Lee, D., and Brooks, D.P. (2000). Apoptosis in polycystic kidney disease: involvement of caspases. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R763-R769. (Pubitemid 30158139)
3. Ashkenazi, A. (2008). Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev. Drug Discov. 7, 1001-1012.
4. Bartke, A. and Brown-Borg, H. (2004). Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63, 189-225. (Pubitemid 39752388)
5. Bartke, A., Chandrashekar, V., Bailey, B., Zaczek, D., and Turyn, D. (2002). Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36, 201-208.
6. Barzilai, N., She, L., Liu, B-Q., Vuguin, P., Cohen, P., Wang, J., and Rossetti, L. (1999). Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98. (Pubitemid 29019357)
7. Boatright, K.M. and Salvesen, G.S. (2003). Mechanisms ofcaspase activation. Curr. Opin. Cell Biol. 15, 725-731.
8. Budihardjo, I., Oliver, H., Lutter, M., Luo, X., and Wang, X. (1999). Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15, 269-290. (Pubitemid 32250377)
9. Campisi, J. (2005). Senescent cells, tumor suppression, and organ-ismal aging: good citizens, bad neighbors. Cell 120, 513-522. (Pubitemid 40269765)
10. Coschigano, K.T. (2006). Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice. AGE 28, 191-200. (Pubitemid 44197729)
11. Coschigano, K.T., Clemmons, D., Bellush, L.L., and Kopchick, J.J. (2000). Assessment of growth parameters and life span of GHR/BP gene disrupted mice. Endocrinology 141, 2608-2613. (Pubitemid 32269083)
12. Coschigano, K.T., Holland, A.N., Riders, M.E., List, E.O., Flyvb-jerg, A., and Kopchick, JJ. (2003). Deletion, but not antago-nism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased lifespan. Endocrinology 144, 3799-3810. (Pubitemid 37088732)
13. Fasshauer, M. and Paschke, R. (2003). Regulation of adipocytokines and insulin resistance. Diabetologia 46, 1594-1603. (Pubitemid 38005321)
14. Faubel, S. and Edelstein, C.L. (2005). Caspases as drug targets in ischemic organ injury. Curr. Drug Targets Immune Endocr. Metabol. Disord. 5, 269-287. (Pubitemid 41131706)
15. Gesing, A., Masternak, M.M., Wang, F., Karbownik-Lewinska, M., Bartke, A. (2011). Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of life span extension. Age, In press.
16. Ghosh, S., Khazaei, M., Moien-Afshari, F., Ang, L.S., Granville, DJ., Verchere, C.B., Dunn, S.R., McCue, P., Mizisin, A., Shar-ma, K., et al. (2009). Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am. J. Physiol. Renal. Physiol. 296, F700-F708.
17. Harper, J.M., Salmon, A.B., Chang, Y., Bonkowski, M., Bartke, A., and Miller, R.A. (2006). Stress resistance and aging: influence of genes and nutrition. Mech. Ageing Dev. 127, 687-694.
18. Henry-Mowatt, J., Dive, C., Martinou, J.C., and James, D. (2004). Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 23, 2850-2860. (Pubitemid 38638847)
19. Holland, W.L., Miller, R.A., Wang, Z.V., Sun, K., Barth, B.M., Bui, H.H., Davis, K.E., Bikman, B.T., Halberg, N., Rutkowski, J.M., et al. (2011). Receptor-mediated activation ofceramidase activ-ity initiates the pleiotropic actions ofadiponectin. Nat. Med. 17, 55-63.
20. Ikeno, Y., Hubbard, G.B., Lee, S., Cortez, L.A., Lew, C.M., Webb, C.R., Berryman, D.E., List, E.O., Kopchick, JJ., and Bartke, A. (2009). Reduced incidence and delayed occurrence of fatal neo-plastic diseases in growth hormone receptor/binding protein knockout mice. J. Gerontol. A Biol. Sci. Med. Sci. 64, 522-529.
21. Jin, Z. and El-Deiry, W.S. (2005). Overview of cell death signaling pathways. Cancer Biol. Ther. 4, 139-163. (Pubitemid 41351311)
22. Kopchick, J.J. and Laron, Z. (1999). Is the Laron mouse an accurate model of Laron syndrome? Mol. Genet. Metab. 68, 232-236. (Pubitemid 29501095)
23. Lagathu, C., Bastard, J.P., Auclair, M., Maachi, M., Capeau, J., and Caron, M. (2003). Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adi-pocyte: prevention by rosiglitazone. Biochem. Biophys. Res. Commun. 311, 372-379. (Pubitemid 37340087)
24. Liu, J.L., Coschigano, K.T., Robertson, K., Lipsett, M., Guo, Y., Kopchick, JJ., Kumar, U., and Liu, Y.L. (2004). Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am. J. Physiol. Endocrinol. Metab. 287, E405-E413. (Pubitemid 39095873)
25. Muzumdar, R., Allison, D.B., Huffman, D.M., Ma, X., Atzmon, G., Einstein, F.H., Fishman, S., Poduval, A.D., McVei, T., Keith, S., et al. (2008). Visceral adipose tissue modulates mammalian lon-gevity. Aging Cell 7, 438-440. (Pubitemid 351663912)
26. Ortiz, A., Ziyadeh, F.N., and Neilson, E.G. (1997). Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J. Investig. Med. 45, 50-56. (Pubitemid 127453337)
27. Renaldi, O., Pramono, B., Sinorita, H., Purnomo, L.B., Asdie, R.H., and Asdie, A.H. (2009). Hypoadiponectinemia: a risk factor for metabolic syndrome. Acta Med. Indones. 41, 20-24.
28. Salmon, A.B., Murakami, S., Bartke, A., Kopchick, JJ., Yasumura, K., and Miller, R.A. (2005). Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am. J. Physiol. Endocrinol. Metab. 289, E23-E29. (Pubitemid 40874930)
29. Shi, H., Strader, A.D., Woods, S.C., and Seeley, RJ. (2007). The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am. J. Physiol. Endocrinol. Metab. 293, E1012-E1020. (Pubitemid 47535832)
30. Shieh, S-Y., Ikeda, M., Taya, Y., and Prives, C. (1997). DNA dam-age-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334. (Pubitemid 27467963)
31. Sorenson, C.M. (2004). Bcl-2 family members and disease. Bio-chim. Biophys. Acta 1644, 169-177. (Pubitemid 38281273)
32. -/- mouse. Am. J. Physiol. 271, F184-F193.
33. Srinivasula, S.M., Datta, P., Fan, X.J., Fernandes-Alnemri, T., Huang, Z., and Alnemri, E.S. (2000). Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway J. Biol. Chem. 275, 36152-36157.
34. Sun, L.Y., Steinbaugh, MJ., Masternak, M.M., Bartke, A., and Mil-ler, R.A. (2009). Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic. Biol. Med. 47, 1753-1761.
35. Tao, Y., Zafar, I., Kim, J., Schrier, R.W., and Edelstein, C.L. (2008). Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J. Am. Soc. Nephrol. 19, 749-755.
36. Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53. (Pubitemid 34062443)
37. Wang, Z., Havasi, A., Gall, J.M., Mao, H., Schwartz, J.H., and Bor-kan, S.C. (2009). β-catenin promotes survival of renal epithelial cells by inhibiting bax. J. Am. Soc. Nephrol. 20, 1919-1928.
38. Wei, Q., Dong, G., Yang, T., Megyesi, J., Price, P.M., and Dong, Z. (2007). Activation and involvement of p53 in cisplatin-induced nephrotoxicity Am. J. Physiol. Renal Physiol. 293, F1282-F1291. (Pubitemid 47583963)
39. L. Cell 87, 619-628. (Pubitemid 26386936)
40. Zhang, H.H., Kumar, S., Barnett, A.H., and Eggo, M.C. (2001). Dexamethasone inhibits tumor necrosis factor-α-induced apop-tosis and interleukin-1β release in human subcutaneous adipo-cytes and preadipocytes. J. Clin. Endocrinol. Metab. 86, 2817-2825. (Pubitemid 32545745)
41. Zhang, X., Zheng, X., Sun, H., Feng, B., Chen, G., Vladau, C., Li, M., Chen, D., Suzuki, M., Min, L., et al. (2006). Prevention of renal ischemic injury by silencing the expression of renal cas-pase 3 and caspase 8. Transplantation 82, 1728-1732. (Pubitemid 46035659)
42. Zhou, L., Fu, P., Huang, X.R., Liu, F., Lai, K.N., and Lan, H.Y. (2010). Activation of p53 promotes renal injury in acute aris-tolochic acid nephropathy J. Am. Soc. Nephrol. 21, 31-41.
43. Zhou, Y., Xu, B.C., Maheshwari, H.G., He, L., Reed, M., Lozy-kowski, M., Okada, S., Cataldo, L., Coschigano, K., Wagner, T.E., et al. (1997). A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl. Acad. Sci. USA 94, 13215-13220. (Pubitemid 27518502)
44. Zou, H., Li, Y., Liu, X., and Wang, X. (1999). An APAF-1. cyto-chrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274, 11549-11556.