Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes

Free Radical Biology and Medicine

Volumn 47, Issue 12, 2009, Pages 1753-1761

  Sun, Liou Y ^a   Steinbaugh, Michael J ^a   Masternak, Michal M ^b   Bartke, Andrzej ^b   Miller, Richard A ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; ERK; Fibroblast; Free radicals; Hydrogen peroxide; Longevity; Snell dwarf mice; Stress resistance

Indexed keywords

CADMIUM; GROWTH HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PARAQUAT; PEROXIDE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; FIBROBLAST; FIBROBLAST CULTURE; GENE INDUCTION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MALE; MOLECULAR MECHANICS; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ANIMALS; EARLY GROWTH RESPONSE PROTEIN 1; FIBROBLASTS; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; LONGEVITY; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; ONCOGENE PROTEINS V-FOS; OXIDATIVE STRESS; PARAQUAT; PHOSPHORYLATION; RECEPTORS, SOMATOTROPIN; SKIN;

MUS;

EID: 70449523451     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.09.021     Document Type: Article

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