Expression of Apoptosis-Regulatory Genes in Renal Proximal Tubular Epithelial Cells Exposed to High Ambient Glucose and in Diabetic Kidneys

Journal of Investigative Medicine

Volumn 45, Issue 2, 1997, Pages 50-56

  Ortiz, Alberto ^a   Ziyadeh, Fuad N ^b   Neilson, Eric G ^b  

^a Laboratorio de Nefrologia   (Spain)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; bax; bcl 2; bclx; Diabetic nephropathy; Tubular epithelium

Indexed keywords

GLUCOSE;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CYTOLOGY; DIABETIC NEPHROPATHY; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; KIDNEY PROXIMAL TUBULE; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROTO ONCOGENE;

ANIMALS; APOPTOSIS; CELL LINE; DIABETIC NEPHROPATHIES; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, BCL-2; GLUCOSE; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED NOD;

EID: 0031062401     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Raff M. Social controls on cell survival and cell death. Nature 1992; 356:397-400.
2. Reed J. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994; 124:1-6.
3. Oltvai Z, Milliman C, Korsmeyer S. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell 1993; 74:609-19.
4. Boise L, Gonzalez-Garcia M, Postema C, Ding L, Lindsten T, Turka L, Mao X, Nunez G, Thompson C. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of cell death. Cell 1993; 74:597-608.
5. Hockenbery D, Oltvai Z, Yin X, Milliman C, Korsmeyer S. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75:241-51.
6. Kane D, Sarafian T, Anton R, Hahn H, Gralla E, Valentine J, Ord T, Bredesen D. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993; 262:1274-7.
7. Rasch R. Tubular lesions in streptozotocin diabetic rats. Diabetologia 1984; 27:32-7.
8. Ziyadeh FN. Renal tubular basement membrane and collagen type IV in diabetes mellitus. Kidney Int 1993; 43:114-20.
9. Mauer SM, Steffes MW, Ellis EN, Sutherland DER, Brown DM, Goetz FC. Structural-functional relationships in diabetic nephropathy. J Clin Invest 1984; 74:1143-55.
10. Ziyadeh FN, Goldfarb S. The renal tubulointerstitium in diabetes mellitus. Kidney Int 1991; 39:464-75.
11. Lane PH, Steffes MW, Fioretto P, Mauer SM. Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney Int 1993; 43:661-7.
12. Jin T, Nordberg GF, Sehlin J, Leffler P, Wu J. The susceptibility of spontaneously diabetic mice to cadmium metallothionein nephrotoxicity. Toxicology 1994; 89:81-90.
13. Lorenzi M, Caagliero E, Toledo S. Glucose toxicity for human endothelial cells in culture: delayed replication, disturbed cell cycle, and accelerated death. Diabetes 1985; 34:621-7.
14. Lorenzi M, Nordberg JA, Toledo S. High glucose prolongs cell cycle traversal of cultured human endothelial cells. Diabetes 1987; 36:1261-7.
15. Wolf G, Sharma K, Chen Y, Ericksen M, Ziyadeh FN. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-b. Kidney Int 1992; 42:647-56.
16. Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, Haverty TP. High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 1990; 259:F704-14.
17. Wolf G, Neilson EG, Goldfarb S, Ziyadeh FN. The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture. Biochem Biophys Res Commun 1991; 176:902-9.
18. Ziyadeh FN, Simmons DA, Snipes ER, Goldfarb S. Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose. J Am Soc Nephrol 1991; 1:1220-9.
19. Rocco MV, Chen Y, Goldfarb S, Ziyadeh FN. Elevated glucose stimulates TGF-b gene expression and bioactivity in proximal tubule. Kidney Int. 1992; 41:107-14.
20. Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-β. J Clin Invest 1994; 93:536-42.
21. Haverty T, Kelly C, Hines W, Amenta P, Watanabe M, Harper R, Kefalides N, Neilson E. Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol 1988; 107:1359-68.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
23. Negrini M, Silini E, Kozak C, Tsujimoto Y, Croce C. Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 1987; 49:455-63.
24. Maniatis F, Fritsch EF, Sambrook J. Molecular cloning. Cold Spring Harbor, New York: New York Press, 1989.
25. Sharma K, Ziyadeh FN. Renal hypertrophy is associated with upregulation of TGF-b1 gene expression in diabetic BB rat and NOD mouse. Am J Physiol 1994;267:F1094-101.
26. Like AA, Lavine RL, Poffenbarger PL, Chick WL. Studies in the diabetic mutant mouse. Amer J Path 1972; 66:193-204.
27. Lee SM, Graham A. Early immunopathologic events in experimental diabetic nephropathy: a study in db/db mice. Exp Mol Pathol 1980; 33:323-32.
28. Ginevri F, Piccotti E, Alinovi R, DeToni T, Biagini C, Chiggeri GM, Gusmano R. Reversible tubular proteinuria precedes microalbuminuria and correlates with metabolic status in diabetic children. Pediatr Nephrol 1993; 7:23-6.
29. Vaamonde CA, Perez GO. Tubular function in diabetes mellitus. Sem in Nephrol 1990; 10:203-18.
30. Hostetter T. Diabetic nephropathy. In: Brenner BM, Rector FC, eds. The kidney. Philadelphia: WB Saunders. 1991:1695-727.
31. Schumer M, Colombel M, Sawczuk I, Gobe G, Connor J, Otoole K, Olsson C, Wise G, Buttyan R. Morphologic, biochemical and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 1992; 140:831-8.
32. Gobe G, Axelsen R. Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Lab Invest 1987; 56:273-81.
33. Ellis RE, Yuan J, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol 1991; 7: 663-98.
34. Savill JS, Wylie AH, Henson JE, Walport MJ, Henson PM, Haslett C. Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 1989; 83: 865-7.
35. Coles HSR, Brune JF, Raff MC. Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Dev 1993; 118: 777-84.
36. Perry VH, Henderson Z, Linden R. Postnatal changes in retinal ganglion cell and optic axon populations in pigmented rat. J Comp Neurol 1983; 219: 356-68.
37. Savill J, Monney A, Hughes J. Apoptosis in acute renal inflammation. In: Neilson EG, WC Couser, eds. Immunologic renal diseases. Philadelphia: Lippincott-Raven. In press.
38. Sharma K, Jin Y, Guo J, Ziyadeh FN: Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in streptozotocin-induced diabetic mice. Diabetes 1996; 45:522-30.