5-benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1- ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2049-2059

  Sunderland, Peter T ^a   Woon, Esther C Y ^a   Dhami, Archana ^a   Bergin, Aoife B ^a   Mahon, Mary F ^b   Wood, Pauline J ^a   Jones, Louise A ^c   Tully, Sophie R ^c   Lloyd, Matthew D ^a   Thompson, Andrew S ^a   Javaid, Hashim ^c   Martin, Niall M B ^c   Threadgill, Michael D ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b University of Bath   (United Kingdom)

^c KuDOS Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (OMEGA CARBOXYALKYL)ISOQUINOLIN 1 ONE DERIVATIVE; 5 ACYLAMINOISOQUINOLIN 1 ONE; 5 AMINOISOQUINOLIN 1 ONE; 5 BENZAMIDOISOQUINOLIN 1 ONE DERIVATIVE; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION;

ANIMALS; CELL LINE, TUMOR; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; ISOENZYMES; ISOQUINOLINES; LACTAMS; MICE; MODELS, MOLECULAR; OXYGEN; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 79953790546     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1010918     Document Type: Article

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