Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4050-4054

  Miyashiro, Julie ^a   Woods, Keith W ^a   Park, Chang H ^a   Liu, Xuesong ^a   Shi, Yan ^a   Johnson, Eric F ^a   Bouska, Jennifer J ^a   Olson, Amanda M ^a   Luo, Yan ^a   Fry, Elizabeth H ^a   Giranda, Vincent L ^a   Penning, Thomas D ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

DNA repair; Nicotinamide; Nuclear enzyme; PARP 1; Poly(ADP ribose)polymerase; Programmed cell death; Quinoxalinone

Indexed keywords

IMIDAZOQUINOXALINONE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PYRROLOQUINOXALINONE; QUINOXALINONE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; SAPONIFICATION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL NUCLEUS; CHEMISTRY, PHARMACEUTICAL; DNA REPAIR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649983992     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.016     Document Type: Article

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21. The coordinates of compound 9c have been deposited in the RCSB Protein Data Bank (PDB ID code 3GJW).
22. +, 200 nM biotinylated histone H1, 200 nM slDNA and 1 nM PARP-1 enzyme. The details are described in Ref. 10b.
23. 2 for 10 min. The details are described in Ref. 10b.