A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)- 5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 3, 2004, Pages 1114-1124

  Iwashita, Akinori ^a   Mihara, Kayoko ^a   Yamazaki, Syunji ^a   Matsuura, Shigeru ^a   Ishida, Junya ^a   Yamamoto, Hirofumi ^a   Hattori, Kouji ^a   Matsuoka, Nobuya ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLOROPHENYL) 5 QUINOXALINECARBOXAMIDE; DOPAMINE; DRUG VEHICLE; ENZYME INHIBITOR; FR 261529; HYDROGEN PEROXIDE; METHAMPHETAMINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DEGENERATIVE DISEASE; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; DRUG ABUSE; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; MOUSE; NERVE ENDING; NEUROTOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STRIATONIGRAL DEGENERATION;

ANIMALS; BENZAMIDES; BODY TEMPERATURE; BRAIN; CORPUS STRIATUM; DOPAMINE; ENZYME INHIBITORS; LIPID PEROXIDATION; METHAMPHETAMINE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PC12 CELLS; POLY(ADP-RIBOSE) POLYMERASES; QUINOXALINES; RATS; SUBSTANTIA NIGRA;

EID: 4243184854     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.068932     Document Type: Article

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