Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues

Hypertension

Volumn 52, Issue 6, 2008, Pages 1149-1154

  Delaloy, Céline ^a,b,c,f   Elvira Matelot, Emilie ^a,b,c   Clemessy, Maud ^c   Zhou, Xiao Ou ^a,b,c   Imbert Teboul, Martine ^d,e   Houot, Anne Marie ^a,b,c   Jeunemaitre, Xavier ^a,b,c   Hadchouel, Juliette ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e CNRS   (France)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

FHHt; Hypertension; Insulator; Repressor; Transgenic; WNK1

Indexed keywords

PROTEIN KINASE WNK1;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; GENE DELETION; GENE IDENTIFICATION; GENE INTERACTION; GENE OVEREXPRESSION; HYPERKALEMIA; HYPERTENSION; INSULATOR ELEMENT; INTRON; KIDNEY DISTAL TUBULE; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRESSOR GENE; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DOGS; EMBRYONIC STEM CELLS; FEMALE; GENE DELETION; GENES, REPORTER; HUMANS; HYPERKALEMIA; HYPERTENSION, RENAL; INTRONS; KIDNEY; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SKELETAL; PROTEIN-SERINE-THREONINE KINASES; SPECIES SPECIFICITY;

EID: 57449120881     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.120899     Document Type: Article

References (20)

1. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science. 2001;293:1107-1112.
2. Kahle KT, Wilson FH, Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends Endocrinol Metab. 2005;16:98-103.
3. Hadchouel J, Delaloy C, Faure S, Achard JM, Jeunemaitre X. Familial hyperkalemic hypertension. J Am Soc Nephrol. 2006;17:208-217.
4. McCormick JA, Yang CL, Ellison DH. WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension. 2008; 51:588-596.
5. Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol. 2003;23:9208-9221.
6. Delaloy C, Hadchouel J, Imbert-Teboul M, Clemessy M, Houot AM, Jeunemaitre X. Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay. Am J Pathol. 2006;169:105-118.
7. Belteki G, Gertsenstein M, Ow DW, Nagy A. Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat Biotechnol. 2003;21:321-324.
8. Kress C, Vandormael-Pournin S, Baldacci P, Cohen-Tannoudji M, Babinet C. Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation. Mamm Genome. 1998;9:998-1001.
9. Hogan B, Beddington R, Costantini F, Lacy E. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1994.
10. Lallemand Y, Luria V, Haffner-Krausz R, Lonai P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Res. 1998;7:105-112.
11. Davissen RL, Nuutinen N, Coleman ST, Sigmund CD. Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res. 1996;24:4023-4028.
12. Nobrega MA, Ovcharenko I, Afzal V, Rubin EM. Scanning human gene deserts for long-range enhancers. Science. 2003;302:413.
13. Bao L, Zhou M, Cui Y. CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res. 2008;36(database issue):D83-D87.
14. Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest. 2005;115:1379-1387.
15. Lazrak A, Liu Z, Huang CL. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A. 2006; 103:1615-1620.
16. Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA. WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci U S A. 2006;103: 8558-8563.
17. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A. 2005;102:10315-10320.
18. Disse-Nicodeme S, Corvol P, Jeunemaitre X, Achard JM. Two genes involved in human familial hypertension. M S-Med Sci. 2001;17:959-962.
19. Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP. WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc Natl Acad Sci U S A. 2007;104:4020-4024.
20. Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter U, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003;100:14109-14114.