Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 3, 2009, Pages

  Vallon, Volker ^a,b,c,g   Schroth, Jana ^c   Lang, Florian ^d   Kuhl, Dietmar ^e   Uchida, Shinichi ^f  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e HUMBOLDT UNIVERSITY   (Germany)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diuretic; Epithelial sodium channel; Intake; Sodium chloride; With no lysine kinases

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; POTASSIUM; SERINE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHLORIDE; SODIUM CHLORIDE COTRANSPORTER; THREONINE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH POTASSIUM INTAKE; HOMEOSTASIS; IN VIVO CULTURE; MOUSE; NONHUMAN; POTASSIUM EXCRETION; POTASSIUM INTAKE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SALT INTAKE; SODIUM RESTRICTION; SODIUM RETENTION; WILD TYPE;

EID: 69449100055     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00030.2009     Document Type: Article

References (52)

1. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol 291: F714-F721, 2006. (Pubitemid 44506967)
2. Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74: 1403-1409, 2008.
3. De Jong JC, Willems PH, Mooren FJ, van den Heuvel LP, Knoers NV, Bindels RJ. The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer. J Biol Chem 278: 24302-24307, 2003.
4. Delpire E, Gagnon KB. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J 409: 321-331, 2008. (Pubitemid 351184951)
5. Ecelbarger CA, Kim GH, Wade JB, Knepper MA. Regulation of the abundance of renal sodium transporters and channels by vasopressin. Exp Neurol 171: 227-234, 2001. (Pubitemid 32955284)
6. + channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol 294: F1298-F1305, 2008.
7. Flatman PW. Cotransporters, WNKs and hypertension: an update. Curr Opin Nephrol Hypertens 17: 186-192, 2008.
8. Frindt G, Ergonul Z, Palmer LG. Surface expression of epithelial Na channel protein in rat kidney. J Gen Physiol 131: 617-627, 2008. (Pubitemid 351749201)
9. Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians 79: 221-235, 1966.
10. Guyton AC. Physiologic regulation of arterial pressure. Am J Cardiol 8: 401-407, 1961.
11. Huang CL, Yang SS, Lin SH. Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 17: 519-525, 2008.
12. + elimination in the sgk1-knockout mouse. J Am Soc Nephrol 15: 885-891, 2004.
13. Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases. Annu Rev Physiol 70: 329-355, 2008.
14. Kim GH, Martin SW, Fernandez-Llama P, Masilamani S, Packer RK, Knepper MA. Long-term regulation of renal Na-dependent cotransporters and ENaC: response to altered acid-base intake. Am J Physiol Renal Physiol 279: F459-F467, 2000.
15. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998. (Pubitemid 28549405)
16. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86: 1151-1178, 2006. (Pubitemid 44521650)
17. Li J, Wang DH. Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model. J Hypertens 25: 1065-1072, 2007. (Pubitemid 46573126)
18. Loffing J, Flores SY, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol 68: 461-490, 2006.
19. 2+ handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol 15: 2276-2288, 2004.
20. McCormick JA, Yang CL, Ellison DH. WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension 51: 588-596, 2008.
21. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H. WNK1 regulates phosphorylation of cation-chloride- coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005. (Pubitemid 43049227)
22. Morris RG, Hoorn EJ, Knepper MA. Hypokalemia in a mouse model of Gitelman's syndrome. Am J Physiol Renal Physiol 290: F1416-F1420, 2006. (Pubitemid 43830767)
23. Nielsen J, Kwon TH, Masilamani S, Beutler K, Hager H, Nielsen S, Knepper MA. Sodium transporter abundance profiling in kidney: effect of spironolactone. Am J Physiol Renal Physiol 283: F923-F933, 2002. (Pubitemid 35192458)
24. O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW. Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17: 2402-2413, 2006. (Pubitemid 44300956)
25. - cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. J Biol Chem 281: 28755-28763, 2006.
26. + channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1. Biochem Biophys Res Commun 311: 629-634, 2003.
27. Pearce D. SGK1 regulation of epithelial sodium transport. Cell Physiol Biochem 13: 13-20, 2003. (Pubitemid 36359377)
28. Richardson C, Alessi DR. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci 121: 3293-3304, 2008.
29. - cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008.
30. + and water reabsorption. FASEB J 21: 3717-3726, 2007.
31. Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H. The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int 72: 566-573, 2007. (Pubitemid 47312793)
32. - cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci USA 102: 16777-16782, 2005.
33. + homeostasis. Proc Natl Acad Sci USA 104: 4025-4029, 2007.
34. Riveira-Munoz E, Chang Q, Bindels RJ, Devuyst O. Gitelman's syndrome: towards genotype-phenotype correlations? Pediatr Nephrol 22: 326-332, 2007. (Pubitemid 46766753)
35. - cotransporter. Am J Physiol Renal Physiol 295: F1199-F1206, 2008.
36. - cotransporter of the distal convoluted tubule. J Biol Chem 273: 29150-29155, 1998.
37. Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996. (Pubitemid 26011315)
38. - cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone. Kidney Int 74: 1373-1375, 2008.
39. Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol 19: 1732-1740, 2008.
40. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F. KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci USA 102: 17864-17869, 2005. (Pubitemid 41803588)
41. Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B, Cunard R, Stockand J. Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity. J Am Soc Nephrol 20: 721-729, 2009.
42. Vallon V, Wulff P, Huang DY, Loffing J, Volkl H, Kuhl D, Lang F. Role of Sgk1 in salt and potassium homeostasis. Am J Physiol Regul Integr Comp Physiol 288: R4-R10, 2005. (Pubitemid 40023904)
43. Verlander JW, Tran TM, Zhang L, Kaplan MR, Hebert SC. Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats. J Clin Invest 101: 1661-1669, 1998. (Pubitemid 28198495)
44. Verrey F, Fakitsas P, Adam G, Staub O. Early transcriptional control of ENaC (de)ubiquitylation by aldosterone. Kidney Int 73: 691-696, 2008. (Pubitemid 351323253)
45. Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005. (Pubitemid 41445471)
46. Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP. Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci USA 106: 226-231, 2009.
47. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001. (Pubitemid 32758085)
48. + retention in the sgk1-knockout mouse. J Clin Invest 110: 1263-1268, 2002.
49. Yang CL, Zhu X, Ellison DH. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest 117: 3403-3411, 2007. (Pubitemid 350096996)
50. Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5: 331-344, 2007. (Pubitemid 46679517)
51. Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, Welling PA. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem 278: 23066-23075, 2003. (Pubitemid 36830372)
52. + channel alpha. J Clin Invest 117: 773-783, 2007.