Regulation of diverse ion transport pathways by WNK4 kinase: A novel molecular switch

Trends in Endocrinology and Metabolism

Volumn 16, Issue 3, 2005, Pages 98-103

  Kahle, Kristopher T ^a   Wilson, Frederick H ^a   Lifton, Richard P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PHOSPHOTRANSFERASE; POTASSIUM; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SODIUM CHANNEL; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

BLOOD PRESSURE; BRAIN; CARBOXY TERMINAL SEQUENCE; CHLORIDE TRANSPORT; CHROMOSOME 1; CHROMOSOME 12; CONFOCAL MICROSCOPY; DRUG EFFECT; GENE DELETION; GENE MUTATION; GENETIC HETEROGENEITY; GENOME ANALYSIS; HEART; HOMEOSTASIS; HUMAN; HYPERKALEMIA; HYPERTENSION; IMMUNOHISTOCHEMISTRY; ION TRANSPORT; MOLECULAR GENETICS; NEPHRON; PATHOGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 15944412561     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2005.02.012     Document Type: Review

References (39)

1. W.K. Paver, and G.J. Paulilne Hypertension and hyperpotassaemia without renal disease in a young male Med. J. Aust. 35 1964 305 306
2. R.D. Gordon Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate Hypertension 8 1986 93 102
3. M. Schambelan Mineralocorticoid-resistant renal hyperkalemia without NaCl wasting (type II pseudohypoaldosteronism): role of increased renal Cl- reabsorption Kidney Int. 19 1981 716 727
4. R.P. Lifton Molecular mechanisms of human hypertension Cell 104 2001 545 556
5. B.E. Xu WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension Cell Res. 15 2005 6 10
6. G. Gamba Role of WNK kinases in regulating tubular NaCl and K+ transport and in the development of hypertension Am. J. Physiol. Renal Physiol. 288 2005 F245 F252
7. J. Hadchouel WNK1 and WNK4, new players in NaCl and water homeostasis Med Sci (Paris). 21 2005 55 60
8. T.A. Mansfield Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21 Nat. Genet. 16 1997 202 205
9. F.H. Wilson Human hypertension caused by mutations in WNK kinases Science 293 2001 1107 1112
10. B. Xu WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II J. Biol. Chem. 275 2000 16795 16801
11. F. Verissimo, and P. Jordan WNK kinases, a novel protein kinase subfamily in multi-cellular organisms Oncogene 20 2001 5562 5569
12. B.E. Xu Regulation of WNK1 by an autoinhibitory domain and autophosphorylation J. Biol. Chem. 277 2002 48456 48462
13. X. Min Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension Structure 12 2004 1303 1311
14. A.C. Vitari WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate Biochem. J. 378 2004 257 268
15. B.E. Xu WNK1 activates ERK5 by an MEKK2/3-dependent mechanism J. Biol. Chem. 279 2004 7826 7831
16. D.B. Simon Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter Nat. Genet. 12 1996 24 30
17. F.H. Wilson Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 Proc. Natl. Acad. Sci. U. S. A. 100 2003 680 684
18. C.L. Yang WNK kinases regulate thiazide-sensitive Na-Cl cotransport J. Clin. Invest. 111 2003 1039 1045
19. K.T. Kahle WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion Nat. Genet. 35 2003 372 376
20. R.J. Bindels A molecular switch controlling renal sodium and K+ excretion Nat. Genet. 35 2003 302 303
21. C.M. Van Itallie, and J.M. Anderson The molecular physiology of tight junction pores Physiology (Bethesda). 19 2004 331 338
22. S Tsukita, and M. Furuse Claudin-based barrier in simple and stratified cellular sheets Curr. Opin. Cell. Biol. 14 2002 531 536
23. J.L. Madara Regulation of the movement of solutes across tight junctions Annu. Rev. Physiol. 60 1998 143 159
24. Y. Peter, and D. Goodenough Claudins Curr. Biol. 14 2004 R293 R294
25. D.B. Simon Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption Science 285 1999 103 106
26. E.R. Wilcox Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29 Cell 104 2001 165 172
27. O.R. Colegio Claudins create charge-selective channels in the paracellular pathway between epithelial cells Am. J. Physiol. 283 2002 C14 C147
28. V.W. Tang, and D.A. Goodenough Paracellular ion channel at the tight junction Biophys. J. 84 2003 1660 1673
29. K. Yamauchi Disease-causing mutant WNK4 increases paracellular Cl- permeability and phosphorylates claudins Proc. Natl. Acad. Sci. U. S. A. 101 2004 4690 4694
30. K.T. Kahle Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension Proc. Natl. Acad. Sci. U. S. A. 101 2004 14877 14882
31. K.T. Kahle WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia Proc. Natl. Acad. Sci. U. S. A. 101 2004 2064 2069
32. K.A. Choate WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl - transporting epithelia Proc. Natl. Acad. Sci. U. S. A. 100 2003 663 668
33. K. Piechotta Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase J. Biol. Chem. 278 2003 52848 52856
34. B.F. Dowd, and B. Forbush PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1) J. Biol. Chem. 278 2003 27347 27353
35. B.H. Lee WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding Mol. Cell 15 2004 741 751
36. B.P. Zambrowicz Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention Proc. Natl. Acad. Sci. U. S. A. 100 2003 14109 14114
37. M. Ito Regulation of blood pressure by the type 1A angiotensin II receptor gene Proc. Natl. Acad. Sci. U. S. A. 92 1995 3521 3525
38. T. Sugaya Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia J. Biol. Chem. 270 1995 18719 18722
39. J.H. Krege Male-female differences in fertility and blood pressure in ACE-deficient mice Nature 375 1995 146 148