SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2

Molecular and Cellular Biology

Volumn 30, Issue 12, 2010, Pages 3027-3037

  Reiche, Juliane ^a   Theilig, Franziska ^a   Rafiqi, Fatema H ^b   Carlo, Anne Sophie ^a   Militz, Daniel ^a   Mutig, Kerim ^a   Todiras, Mihail ^a   Christensen, Erik Ilsø ^c   Ellison, David H ^d   Bader, Michael ^a   Nykjaer, Anders ^c   Bachmann, Sebastian ^a   Alessi, Dario ^b   Willnow, Thomas E ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c AARHUS UNIVERSITY   (Denmark)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVATOR; PROTEIN KINASE; SIGNAL PEPTIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; SORTING PROTEIN RELATED RECEPTOR WITH A TYPE REPEAT; STE 20 RELATED PROLINE ALANINE RICH KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; GENETIC ASSOCIATION; HENLE LOOP; MOUSE; NEPHRON; NONHUMAN; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SODIUM ABSORPTION;

ANIMALS; ENDOCRINE SYSTEM; EPITHELIAL SODIUM CHANNEL; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IONS; KIDNEY; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, BIOLOGICAL; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, LDL; SALTS; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SUBCELLULAR FRACTIONS; TISSUE EXTRACTS;

MUS;

EID: 77953446507     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01560-09     Document Type: Article

References (30)

1. Andersen, O. M., J. Reiche, V. Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C. A. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K. R. Bales, R. Cappai, C. L. Masters, J. Gliemann, E. J. Mufson, B. T. Hyman, S. M. Paul, A. Nykjaer, and T. E. Willnow. 2005. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U. S. A. 102:13461-13466.
2. Benziane, B., S. Demaretz, N. Defontaine, N. Zaarour, L. Cheval, S. Bourgeois, C. Klein, M. Froissart, A. Blanchard, M. Paillard, G. Gamba, P. Houillier, and K. Laghmani. 2007. NKCC2 surface expression in mammalian cells: down-regulation by novel interaction with aldolase B. J. Biol. Chem. 282:33817-33830.
3. Darman, R. B., and B. Forbush. 2002. A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J. Biol. Chem. 277:37542-37550.
4. Delpire, E., and K. B. Gagnon. 2008. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem. J. 409:321-331.
5. Dowd, B. F., and B. Forbush. 2003. PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J. Biol. Chem. 278:27347-27353.
6. Flemmer, A. W., I. Gimenez, B. F. Dowd, R. B. Darman, and B. Forbush. 2002. Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J. Biol. Chem. 277:37551-37558.
7. Geng, Y., A. Hoke, and E. Delpire. 2009. The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. J. Biol. Chem. 284:14020-14028.
8. Giménez, I. 2006. Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters. Curr. Opin. Nephrol. Hypertens. 15:517-523.
9. Giménez, I., and B. Forbush. 2003. Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein. J. Biol. Chem. 278:26946-26951.
10. Gross, V., J. Tank, M. Obst, R. Plehm, K. J. Blumer, A. Diedrich, J. Jordan, and F. C. Luft. 2005. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288:R1134-R1142.
11. Jacobsen, L., P. Madsen, S. K. Moestrup, A. H. Lund, N. Tommerup, A. Nykjaer, L. Sottrup-Jensen, J. Gliemann, and C. M. Petersen. 1996. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J. Biol. Chem. 271:31379-31383.
12. Marcusson, E. G., B. F. Horazdovsky, J. L. Cereghino, E. Gharakhanian, and S. D. Emr. 1994. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77:579-586.
13. Meade, P., R. S. Hoover, C. Plata, N. Vazquez, N. A. Bobadilla, G. Gamba, and S. C. Hebert. 2003. cAMP-dependent activation of the renal-specific Na+-K+-2Cl- cotransporter is mediated by regulation of cotransporter trafficking. Am. J. Physiol. Renal Physiol. 284:F1145-F1154.
14. Moriguchi, T., S. Urushiyama, N. Hisamoto, S. Iemura, S. Uchida, T. Natsume, K. Matsumoto, and H. Shibuya. 2005. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J. Biol. Chem. 280:42685-42693.
15. Mörwald, S., H. Yamazaki, H. Bujo, J. Kusunoki, T. Kanaki, K. Seimiya, N. Morisaki, J. Nimpf, W. J. Schneider, and Y. Saito. 1997. A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens. Arterioscler. Thromb. Vasc. Biol. 17:996-1002.
16. Nielsen, M. S., C. Gustafsen, P. Madsen, J. R. Nyengaard, G. Hermey, O. Bakke, M. Mari, P. Schu, R. Pohlmann, A. Dennes, and C. M. Petersen. 2007. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol. Cell. Biol. 27:6842-6851.
17. Offe, K., S. E. Dodson, J. T. Shoemaker, J. J. Fritz, M. Gearing, A. I. Levey, and J. J. Lah. 2006. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J. Neurosci. 26:1596-1603.
18. Ortiz, P. A. 2006. cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP. Am. J. Physiol. Renal Physiol. 290:F608-F616.
19. Piechotta, K., J. Lu, and E. Delpire. 2002. Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J. Biol. Chem. 277:50812-50819.
20. Rafiqi, F. H., A. M. Zuber, M. Glover, C. Richardson, S. Fleming, S. Jovanovic, A. Jovanovic, K. M. O'Shaughnessy, and D. R. Alessi. 2010. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol. Med. 2:63-75.
21. Richardson, C., and D. R. Alessi. 2008. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J. Cell Sci. 121:3293-3304.
22. Richardson, C., F. H. Rafiqi, H. K. Karlsson, N. Moleleki, A. Vandewalle, D. G. Campbell, N. A. Morrice, and D. R. Alessi. 2008. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J. Cell Sci. 121:675-684.
23. Riedel, I. B., I. Hermans-Borgmeyer, and C. A. Hubner. 2002. SorLA, a member of the LDL receptor family, is expressed in the collecting duct of the murine kidney. Histochem. Cell Biol. 118:183-191.
24. Rohe, M., A. S. Carlo, H. Breyhan, A. Sporbert, D. Militz, V. Schmidt, C. Wozny, A. Harmeier, B. Erdmann, K. R. Bales, S. Wolf, G. Kempermann, S. M. Paul, D. Schmitz, T. A. Bayer, T. E. Willnow, and O. M. Andersen. 2008. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J. Biol. Chem. 283:14826-14834.
25. Russell, J. M. 2000. Sodium-potassium-chloride cotransport. Physiol. Rev. 80:211-276.
26. Schmidt, V., A. Sporbert, M. Rohe, T. Reimer, A. Rehm, O. M. Andersen, and T. E. Willnow. 2007. SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J. Biol. Chem. 282:32956-32964.
27. Simon, D. B., F. E. Karet, J. M. Hamdan, A. DiPietro, S. A. Sanjad, and R. P. Lifton. 1996. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat. Genet. 13:183-188.
28. Takahashi, N., D. R. Chernavvsky, R. A. Gomez, P. Igarashi, H. J. Gitelman, and O. Smithies. 2000. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc. Natl. Acad. Sci. U. S. A. 97:5434-5439.
29. Willnow, T. E., C. M. Petersen, and A. Nykjaer. 2008. VPS10P-domain receptors - regulators of neuronal viability and function. Nat. Rev. Neurosci. 9:899-909.
30. Yamazaki, H., H. Bujo, J. Kusunoki, K. Seimiya, T. Kanaki, N. Morisaki, W. J. Schneider, and Y. Saito. 1996. Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J. Biol. Chem. 271:24761-24768.