Renal and brain isoforms of WNK3 have opposite effects on NCCT expression

Journal of the American Society of Nephrology

Volumn 20, Issue 6, 2009, Pages 1314-1322

  Glover, Mark ^a   Zuber, Annie Mercier ^a   O'Shaughnessy, Kevin M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN KINASE; PROTEIN KINASE SPAK; PROTEIN KINASE WNK1; PROTEIN KINASE WNK3; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SCAFFOLD PROTEIN; SODIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME INHIBITION; EXON; GENE MUTATION; KIDNEY; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SODIUM TRANSPORT; TISSUE DISTRIBUTION; UPREGULATION; XENOPUS;

EID: 67449090606     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008050542     Document Type: Article

References (25)

1. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial: Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid- Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) [published erratum appears in JAMA 289: 178, 2003 and JAMA 291: 2196, 2004]. JAMA 288: 2981-2997, 2002
2. Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, Sever PS, McInnes GT, Thom S: Guidelines for management of hypertension: Report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens 18: 139-185, 2004 (Pubitemid 38425770)
3. Wilson FH, Disse-Nicodeme S, Chate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunal M, Milford DV, Lipkin GW, Achard JM, Feeley MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP: Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001 (Pubitemid 32758085)
4. Golbang AP, Murthy M, Hamad A, Liu C-H, Cope G, Van't Hoff W, Cuthbert AW, O'Shaughnessy KM: A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension 46: 295-300, 2005
5. Golbang AP, Cope G, Hamad A, Murthy M, Liu C-H, Cuthbert AW, O'Shaughnessy KM: Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: Evidence that accelerated dynamindependent endocytosis is not involved. Am J Physiol Renal Physiol 291: F1369-F1376, 2006 (Pubitemid 44887251)
6. Cope G, Golbang AP, O'Shaughnessy KM: WNK kinases and the control of blood pressure. Pharmacol Ther 106: 221-231, 2006
7. Subramanya AR, Wade JB, Ellison DH, Welling PA: The carboxyl terminus of WNK4 suppresses forward trafficking of the thiazidesensitive cotransporter. FASEB J 21: 938.14-2007. www.fasebj.org/ cgi/content/meeting/abstract/21/6/ A1337-a. Accessed April 9, 2009.
8. Yang CL, Zhu X, Ellison DH: The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest 117: 3403-3411, 2007 (Pubitemid 350096996)
9. Richardson C, Rafiq FH, Karlsson HKR, Molelek N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR: Activation of the thiazide-sensitive Na-Cl cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008
10. De los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vazquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G: WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci U S A 103: 1976-1981, 2006
11. Gagnon KB, England R, Diehl L, Delpire E: Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-Cl cotransporter regulation. Am J Physiol Cell Physiol 292: C1809-C1815, 2007 (Pubitemid 47080541)
12. Holden S, Cox J, Raymond FL: Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). Gene 335: 109-119, 2004 (Pubitemid 38759757)
13. Kahle KT, Rinehart J, De los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP: WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci U S A 102: 16783-16788, 2005
14. Rinehart J, Kahle KT, De los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A 102: 16777-16782, 2005
15. Kahle KT, Ring AM, Lifton RP: Molecular physiology of the WNK kinases. Annu Rev Physiol 70: 329-355, 2008 (Pubitemid 351738183)
16. Pacheco-Alvarez D, Cristobal PS, Meade P, Moreno E, Vazquez N, Munoz E, Diaz A, Juarez ME, Gimenez I, Gamba G: The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. J Biol Chem 281: 28755-28763, 2006 (Pubitemid 44507018)
17. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK-1 regulates phosphorylation of cation-chloride- coupled cotransporters via the STE related kinases, SPAK and OSR-1. J Biol Chem 280: 42685-42693, 2005 (Pubitemid 43049227)
18. Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005 (Pubitemid 41445471)
19. Ponce-Coria J, San Cristobal P, Kahle KT, Vasquez N, Pacheco-Alvarez D, De los Heros P, Juarez P Munoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G: Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci U S A 105: 8458-8463, 2008
20. Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM: WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. J Am Soc Nephrol 17: 1867-1874, 2006 (Pubitemid 44036171)
21. Wang HR, Liu Z, Huang CL: Domains of WNK1 kinase in the regulation of ROMK1. Am J Physiol Renal Physiol 295: F438-F445, 2008
22. Gagnon KB, England R, Delpire E: Volume sensitivity of cation Cl- cotransporters is modulated by the interaction of two kinases: Sterelated proline-alanine-rich kinase and WNK4. Am J Cell Physiol 290: C134-C142, 2006
23. Darman RB, Forbush B: A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J Biol Chem 277: 37542-37550, 2002
24. Lin S-H, Shiang J-C, Huang C-C, Yang S-S, Hsu Y-J, Cheng C-J: Phenotype and genotype analysis in Chinese Patients with Gitelman's syndrome. J Clin Endocrinol Metab 90: 2500-2507, 2005 (Pubitemid 40686283)
25. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC: Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium-(potassium)- chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994 (Pubitemid 24218059)