Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population

Circulation

Volumn 112, Issue 22, 2005, Pages 3423-3429

  Tobin, Martin D ^a   Raleigh, Stuart M ^b   Newhouse, Stephen ^c   Braund, Peter ^b   Bodycote, Clare ^b   Ogleby, Jenny ^b   Cross, Deborah ^b   Gracey, Jay ^b   Hayes, Saija ^b   Smith, Terry ^b   Ridge, Cathy ^b   Caulfield, Mark ^c   Sheehan, Nuala A ^a   Munroe, Patricia B ^c   Burton, Paul R ^a   Samani, Nilesh J ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Blood pressure; Genetics; Hypertension; Kidney; Risk factors

Indexed keywords

ANTIHYPERTENSIVE AGENT; PROTEIN SERINE THREONINE KINASE; WNK1 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; DIASTOLIC BLOOD PRESSURE; DIET; ELECTROLYTE BALANCE; EUROPE; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; HAPLOTYPE; HERITABILITY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PSEUDOHYPOALDOSTERONISM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WNK1 GENE; WNK4 GENE; ADOLESCENT; BLOOD PRESSURE; EPIDEMIOLOGY; FAMILY HEALTH; FEEDING BEHAVIOR; GENETICS; MIDDLE AGED;

ADOLESCENT; ADULT; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CARDIOVASCULAR DISEASES; EPIDEMIOLOGY, MOLECULAR; EUROPE; FAMILY HEALTH; FEMALE; FOOD HABITS; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES;

EID: 33644874530     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.555474     Document Type: Article

References (28)

1. National Institutes of Health. JNC 7 Express: the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Bethesda, Md: National Institutes of Health; 2003.
2. Murray CJ, Lauer JA, Hutubessy RC, Niessen L, Tomijima N, Rodgers A, Lawes CM, Evans DB. Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk. Lancet. 2003;361: 717-725.
3. Kotchen TA, Kotchen JM, Grim CE, George V, Kaldunski ML, Cowley AW, Hamet P, Chelius TH. Genetic determinants of hypertension: identification of candidate phenotypes. Hypertension. 2000;36:7-13.
4. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension. 2000;36:477-483.
5. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001;104:545-556.
6. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science. 2001;293:1107-1112.
7. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003;100: 680-684.
8. Yang CL, Angell J, Mitchell R, Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003;111:1039-1045.
9. Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab. 2002;87:3248-54.
10. Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension. 2003;41:1191-1195.
11. Kokubo Y, Kamide K, Inamoto N, Tanaka C, Banno M, Takiuchi S, Kawano Y, Tomoike H, Miyata T. Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. J Hum Genet. 2004;49:507-515.
12. Speirs HJ, Morris BJ. WNK4 intron 10 polymorphism is not associated with hypertension. Hypertension. 2004;43:766-768.
13. Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB. Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study. Hum Mol Genet. 2005;14:1805-1814.
14. Steam DO, Haiman CA, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Pike MC. Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Hum Hered. 2003;55:27-36.
15. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet. 1998; 63:259-266.
16. JLIN: Java LINkage disequilibrium plotter. Available at http:// www.genepi.com.au/jlin; last accessed February 11, 2005.
17. Burton PR, Tiller KJ, Gurrin LC, Cookson WO, Musk AW, Palmer LJ. Genetic variance components analysis for binary phenotypes using generalized linear mixed models (GLMMs) and Gibbs sampling. Genet Epidemiol. 1999;17:118-140.
18. Spiegelhalter D, Thomas A, Best N. WinBUGS Version 1.4 UserManual. Cambridge, England: MRC Biostatistics Unit; 2003.
19. Tobin MD, Sheehan NA, Scurrah KJ, Burton PR. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med. 2005;24:2911-2935.
20. Burton PR, Gurrin LC, Campbell MJ. Clinical significance not statistical significance: a simple Bayesian alternative to p values. J Epidemiol Community Health. 1998;52:318-323.
21. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol. 2004;26:61-69.
22. Allison DB, Heo M, Kaplan N, Martin ER. Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet. 1999;64: 1754-1763.
23. Davey Smith G, Ebrahim S. 'Mendelian randomisation': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32:1-22.
24. Primatesta P, Brookes M, Poulter NR. Improved hypertension management and control: results from the health survey for England 1998. Hypertension. 2001;38:827-932.
25. Joint Health Surveys Unit. Health Survey for England 2003. Volume 2: Risk Factors for Cardiovascular Disease. London: The Stationery Office; 2004.
26. Burton PR. Correcting for non-random ascertainment in generalized linear mixed models (GLMMs) fitted using Gibbs sampling. Genet Epidemiol. 2003;24:24-35.
27. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-1913.
28. Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER 3rd, Simons-Morton DG, Karanja N, Lin PH, Group DA-SCR. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet; DASH-Sodium Collaborative Research Group. N Engl J Med. 2001; 344:3-10.