Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells

Oncology Letters

Volumn 2, Issue 3, 2011, Pages 549-556

  Peng, Xing Xiang ^a,e   Shi, Zhi ^a,b   Tiwari, Amit K ^a   Damaraju, Vijaya L ^c   Fu, Liwu ^b   Cass, Carol E ^c   Ashby Jr, Charles R ^a   Kruh, Gary D ^d   Chen, Zhe Sheng ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF ILLINOIS   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

6 mercaptopurine; ATP binding cassette transporter; Chronic myeloid leukemia; Multidrug resistance; P glycoprotein

Indexed keywords

2 MERCAPTOPURINE; 6 METHYLTHIOINOSINE; ADEFOVIR; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; CYTARABINE; DRUG METABOLITE; GLYCOPROTEIN P; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MERCAPTOPURINE; MESSENGER RNA; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOSIDE TRANSPORTER; PURINE DERIVATIVE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; CANCER RESISTANCE; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; DRUG SENSITIVITY; DRUG TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; UPREGULATION;

EID: 79953286779     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.288     Document Type: Article

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