Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside

Biochemical Pharmacology

Volumn 72, Issue 7, 2006, Pages 816-823

  Fotoohi, Alan Kambiz ^a   Wrabel, Anna ^a   Moshfegh, Ali ^a   Peterson, Curt ^b   Albertioni, Freidoun ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

6 Mercaptopurine; 6 Thioguanine; De novo purine synthesis; Enhanced sensitivity; Equiliberative nucleoside transporter 1; Methyl mercaptopurineriboside

Indexed keywords

ADENOSINE; DIPYRIDAMOLE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GUANINE MONOPHOSPHATE SYNTHETASE; MERCAPTOPURINE; MERCAPTOPURINE RIBOSIDE; MESSENGER RNA; METHYLMERCAPTOPURINERIBOSIDE; NITROBENZYLTHIOINOSINE; NUCLEOTIDE TRANSPORTER; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PROTEIN; PURINE; SMALL INTERFERING RNA; SODIUM ION; TIOGUANINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG UPTAKE; GENE TARGETING; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FAMILY; PURINE SYNTHESIS; TRANSPORT KINETICS; WILD TYPE;

6-MERCAPTOPURINE; ADENOSINE KINASE; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GENE SILENCING; HUMANS; INHIBITORY CONCENTRATION 50; POLYMERASE CHAIN REACTION; PURINES; RIBONUCLEOTIDES; RNA, MESSENGER; RNA, SMALL INTERFERING; SODIUM; T-LYMPHOCYTES; THIOGUANINE;

EID: 33748064340     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.019     Document Type: Article

References (13)

1. Elgemeie G.H. Thioguanine, mercaptopurine: their analogs and nucleosides as antimetabolites. Curr Pharm Des 9 (2003) 2627-2642
2. Fotoohi A.K., Lindqvist M., Peterson C., and Albertioni F. Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun 343 (2006) 208-215
3. Vogt M.H., Stet E.H., De Abreu R.A., Bokkerink J.P., Lambooy L.H., and Trijbels F.J. The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts. Biochim Biophys Acta 1181 (1993) 189-194
4. Yamanaka H., Kamatani N., Nishida Y., Nishioka K., and Mikanagi K. Relationship between phosphorylation and cytotoxicity of 2-chloroadenosine and 6-methylmercaptopurine riboside in human cells. Biochim Biophys Acta 798 (1984) 291-294
5. Wiemann M.C., Crabtree G.W., Weitberg A.B., Spremulli E.N., Cummings F.J., Murray C., et al. Phase I trial of the combination of 6-methylmercaptopurine riboside and 5-fluorouracil. Med Oncol Tumor Pharmacother 5 (1988) 113-116
6. Hageboutros A., Hudes G.R., Greene F., LaCreta F.P., Brennan J., and O'Dwyer P.J. Phase I trial of fluorouracil modulation by N-phosphonacetyl-l-aspartate and 6-methylmercaptopurine ribonucleoside (MMPR), and leucovorin in patients with advanced cancer. Invest New Drugs 15 (1997) 139-145
7. Redei I., Green F., Hoffman J.P., Weiner L.M., Scher R., and O'Dwyer P.J. Phase II trial of PALA and 6-methylmercaptopurine riboside (MMPR) in combination with 5-fluorouracil in advanced pancreatic cancer. Invest New Drugs 12 (1994) 319-321
8. Masson E., Synold T.W., Relling M.V., Schuetz J.D., Sandlund J.T., Pui C.H., et al. Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia. Leukemia 10 (1996) 56-60
9. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
10. Plunkett W., Hug V., Keating M.J., and Chubb S. Quantitation of 1-beta-d-arabinofuranosylcytosine 5′-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-d-arabinofuranosylcytosine therapy. Cancer Res 40 (1980) 588-591
11. Inaba M., Fukui M., Yoshida N., Tsukagoshi S., and Sakurai Y. Collateral sensitivity of 6-mercaptopurine-resistant sublines of P388 and L1210 leukemia to the new purine antagonists, 5-carbamoyl-1H-imidazol-4-yl piperonylate and 4-carbamoylimidazolium 5-olate. Cancer Res 42 (1982) 1103-1106
12. Li W., Su D., Mizobuchi H., Martin D.S., Gu B., Gorlick R., Cole P., and Bertino J.R. Status of methylthioadenosine phosphorylase and its impact on cellular response to l-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells. Oncol Res 14 (2004) 373-379
13. Baldwin S.A., Beal P.R., Yao S.Y., King A.E., Cass C.E., and Young J.D. The equilibrative nucleoside transporter family, SLC29. Oflugers Arch 447 (2004) 735-743