Noise in gene expression determines cell fate in Bacillus subtilis

Science

Volumn 317, Issue 5837, 2007, Pages 526-529

  Maamar, Hédia ^a   Raj, Arjun ^a,b   Dubnau, David ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIAL PROTEIN; PROTEIN COMK; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

BACTERIUM; DNA; GENE EXPRESSION; NOISE;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; CELL FATE; COMK GENE; EVOLUTION; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; EVOLUTION; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION, BACTERIAL; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; RNA STABILITY; RNA, BACTERIAL; RNA, MESSENGER; STOCHASTIC PROCESSES; TRANSCRIPTION FACTORS; TRANSFORMATION, BACTERIAL;

BACILLUS SUBTILIS;

EID: 34547604468     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140818     Document Type: Article

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33. We acknowledge the assistance of S. Tyagi, S. Marras, and D. Gold for the gift of the repeat sequence plasmid, for the use of their spectrophotometer and microscope, and for the preparation of fluorescent probes. We also acknowledge D. Rudner for the gift of the codon-optimized CFP and C. S. Peskin for valuable discussions. We also thank S. Tyagi, A. van Oudenaarden, J. Gore, J. Tsang, M. B. Elowitz, G. M. Suel, and P. Mehta for comments on the manuscript, as well as an anonymous reviewer for insightful comments. This work was supported by NIH grant GM 57720. A.R. was supported by NIH grant GM 070357 and by NSF postdoctoral fellowship DMS-0603392.