Dynamics of single mRNPs in nuclei of living cells

Science

Volumn 304, Issue 5678, 2004, Pages 1797-1800

  Shav Tal, Yaron ^a   Darzacq, Xavier ^a   Shenoy, Shailesh M ^a   Fusco, Dahlene ^a   Janicki, Susan M ^b   Spector, David L ^b   Singer, Robert H ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Simons Center for Quantitative Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIFFUSION; PROTEINS; REAL TIME SYSTEMS; RNA;

CELLULAR SYSTEM; NUCLEAR ENVIRONMENT;

GENES;

CELL PROTEIN; MESSENGER RNA;

BIOLOGY;

ANIMAL CELL; ARTICLE; CELL ENERGY; CELL NUCLEUS; CHROMATIN; COMPLEX FORMATION; DIFFUSION; ENERGY TRANSFER; GENE EXPRESSION; MAMMAL CELL; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN TRANSPORT; RNA BINDING;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATE; CAPSID PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; CYTOPLASM; DIFFUSION; ENERGY METABOLISM; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GLOBINS; GREEN FLUORESCENT PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LUMINESCENT PROTEINS; PEROXISOMES; PROTEIN BIOSYNTHESIS; PROTEINS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 2942733310     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099754     Document Type: Article

References (21)

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21. We thank A. Femino for advice on RNA quantification, B. Hong and M. Cammer for programming assistance, F. Macaluso and L. Cummings for the EM work, B. Ovryn for introducing us to Mathematica software, and T. Meier for useful discussions and critical reading of the manuscript. Supported by NIH EB2060 and DOE63056 to R.H.S and GM42694 to D.L.S.