Live Tumor-Promoting Effect of β-Naphthoflavone, a Strong CYP 1A1/2 Inducer, and the Relationship between CYP 1A1/2 Induction and Cx32 Decrease in Its Hepatocarcinogenesis in the Rat

Toxicologic Pathology

Volumn 28, Issue 4, 2000, Pages 540-547

  Shoda, Toshiyuki ^a   Mitsumori, Kunitoshi ^a   Onodera, Hiroshi ^a   Toyoda, Kazuhiro ^a   Uneyama, Chikako ^a   Takada, Koichi ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Connexin; gap junction; neoplasm; P 450; phenobarbital; promotion

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; GLUTATHIONE TRANSFERASE; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER MODEL; CONTROLLED STUDY; ENZYME INDUCTION; EOSINOPHILIA; GENE DISRUPTION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR GROWTH;

ANIMALS; BETA-NAPHTHOFLAVONE; BLOTTING, WESTERN; BODY WEIGHT; CELL COMMUNICATION; CONNEXINS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DIET; ENZYME INDUCTION; GAP JUNCTIONS; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0033861083     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800406     Document Type: Article

References (24)

1. Andersen ME, Mills JJ, Gargas ML, Kedderis L., Birnbaum LS, Neubert D., Greenlee WF (1993). Modeling receptor-mediated processes with dioxin: Implications for pharmacokinetics and risk assessment. Risk Anal 13: 25-36.
2. Brown JP, Dietrich PS (1979). Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test. Activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources. Mutat Res 66: 223-240.
3. Denison MS, Heath-Pagliuso S. (1998). The Ah receptor: A regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bull Environ Contam Toxicol 61: 557-568.
4. DiGiovanni J. (1990). Inhibition of chemical carcinogenesis. In: Chemical Carcinogenesis and Mutagenesis, Copper CS, Grover PL (eds). Springer-Verlag, Berlin, pp 159-253.
5. Diwan BA, Rice JM, Nims RW, Lubet RA, Hu H., Ward JM (1988). P450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats. Cancer Res 48: 2492-2497.
6. Diwan BA, Rice JM, Ohshima M., Ward JR, Dove LF (1985). Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine. J Natl Cancer Inst 74: 509-515.
7. Goodman DG, Maronpot RR, Newberne PM, Popp JA, Squire RA (1994). Proliferative and selected other lesions in the liver of rats. In: Guides for Toxicologic Pathology. STP/ARP/Armed Forces Institute of Pathology, Washington, DC, GI-5.
8. Isogai M., Shimada N., Kamataki T., Imaoka S., Funae Y. (1993). Changes in the amount of cytochromes P450 in rat hepatic microsomes produced by cyclosporin A. Xenobiotica 23: 799-807.
9. Ito N., Hasegawa R., Imaida K., Hirose M., Shirai T. (1996). Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol 48: 113-119.
10. Klaunig JE, Ruch RJ (1990). Role of inhibition of intercellular communication in carcinogenesis. Lab Invest 62: 135-146.
11. Krutovskikh VA, Mesnil M., Mazzoleni G., Yamasaki H. (1995). Inhibition of rat liver gap junction intercellular communication by tumor-promoting agents in vivo: Association with aberrant localization of connexin proteins. Lab Invest 72: 571-577.
12. Laemmli UK (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
13. Lubet RA, Nims RW, Ward JM, Rice JM, Diwan BA (1989). Induction of cytochrome P450b and its relationship to liver tumor promotion. J Am Coll Toxicol 8: 259-268.
14. McKillop D., Case DE (1991). Mutagenicity, carcinogenicity and toxicity of β-naphthoflavone, a potent inducer of P448. Biochem Pharmacol 41: 1-7.
15. Neveu MJ, Babcock KL, Hertzberg EL, Paul DL, Nicholson BJ, Pitot HC (1994). Colocalized alterations in connexin 32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters. Cancer Res 54: 3145-3152.
16. Neveu MJ, Hully JR, Paul DL, Pitot HC (1990). Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation. Cancer Commun 2: 21-31.
17. Peraino C., Fry Rjm, Staffeldt E., Christopher JP (1975). Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Cancer Res 35: 2884-2890.
18. Portier C., Tritscher A., Kohn M., Sewall C., Clark G., Edler L., Hoel D., Lucier G. (1993) Ligand/receptor binding for 2,3,7,8-TCDD: Implications for risk assessment. Fundam Appl Toxicol 20: 48-56.
19. Sato K. (1988). Glutathione S-transferase and hepatocarcinogenesis. Jpn J Cancer Res (Gann) 79: 556-572.
20. Shinozuka H., Lombardi B., Abanobi SE (1982). A comparative study of the efficacy of four barbiturates as promoters of the development of γ-glutamyltranspeptidase-positive foci in the liver of carcinogen treated rats. Carcinogenesis 3: 1017-1020.
21. Shoda T., Mitsumori K., Onodera H., Toyoda K., Uneyama C., Imazawa T., Hirose M. (1999). The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat. Arch Toxicol 73: 373-380.
22. Shoda T., Onodera H., Takeda M., Uneyama C., Imazawa T., Takegawa K., Yasuhara K., Watanabe T., Hirose M., Mitsumori K. (1999). Liver tumor promoting effects of fenbendazole in rats. Toxicol Pathol 27: 553-562.
23. Takeda A., Kanoh M., Shimazu T., Takeuchi N. (1988). Monoclonal antibodies recognizing different epitopes of the 27-kDa gap junction protein in rat liver. J Biochem 104: 901-907.
24. Yamasaki H., Mesnil M., Omori Y., Mironov N., Krutovskikh V. (1995). Intercellular communication and carcinogenesis. Mutat Res 333: 181-188.