Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice

Archives of Toxicology

Volumn 84, Issue 2, 2010, Pages 155-164

  Kawai, Masaomi ^a,b   Saegusa, Yukie ^a,b   Dewa, Yasuaki ^a,b   Nishimura, Jihei ^a,b   Kemmochi, Sayaka ^a,b   Harada, Tomoaki ^a   Ishii, Yuji ^c   Umemura, Takashi ^c   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

8 hydroxydeoxyguanosine; Hepatocarcinogenesis; Mitogen activated protein kinase; Oxidative stress; Piperonyl butoxide

Indexed keywords

CYTOCHROME P450 1A1; DIETHYLNITROSAMINE; MITOGEN ACTIVATED PROTEIN KINASE; PIPERONYL BUTOXIDE; PYRETHROID; REACTIVE OXYGEN METABOLITE;

ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EARLY RESPONSE GENE; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CARCINOMA; MALE; METABOLIC STRESS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BODY WEIGHT; CELL PROLIFERATION; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; ORGAN SIZE; PESTICIDE SYNERGISTS; PIPERONYL BUTOXIDE; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

MUS; RATTUS;

EID: 76949094165     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0498-8     Document Type: Article

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