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Volumn 73, Issue 7, 2008, Pages

Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay

Author keywords

Antioxidant; Food additives; Isoquercitrin; Purple corn color; Rat medium term liver bioassay

Indexed keywords

ANTHOCYANIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; DIETHYLNITROSAMINE; DRUG DERIVATIVE; FLAVONOID; FOOD ADDITIVE; GLUTATHIONE TRANSFERASE; ISOQUERCITRIN; QUERCETIN; RNA;

EID: 51349140443     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2008.00862.x     Document Type: Article
Times cited : (37)

References (44)
  • 1
    • 0029975684 scopus 로고    scopus 로고
    • In vitro anticancer activity of fruit extracts from Vaccinium species
    • Bomser J, Madhavi DL, Singletary K, Smith MA. 1996. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62 (3 212 6.
    • (1996) Planta Med , vol.62 , Issue.3 , pp. 212-6
    • Bomser, J.1    Madhavi, D.L.2    Singletary, K.3    Smith, M.A.4
  • 2
    • 3242712294 scopus 로고    scopus 로고
    • Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model
    • De S, Chakraborty RN, Ghosh S, Sengupta A, Das S. 2004. Comparative evaluation of cancer chemopreventive efficacy of alpha-tocopherol and quercetin in a murine model. J Exp Clin Cancer Res 23 (2 251 8.
    • (2004) J Exp Clin Cancer Res , vol.23 , Issue.2 , pp. 251-8
    • De, S.1    Chakraborty, R.N.2    Ghosh, S.3    Sengupta, A.4    Das, S.5
  • 3
    • 34247212395 scopus 로고    scopus 로고
    • Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats
    • Emura K, Yokomizo A, Toyoshi T, Moriwaki M. 2007. Effect of enzymatically modified isoquercitrin in spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 53 (1 68 74.
    • (2007) J Nutr Sci Vitaminol (Tokyo) , vol.53 , Issue.1 , pp. 68-74
    • Emura, K.1    Yokomizo, A.2    Toyoshi, T.3    Moriwaki, M.4
  • 4
    • 0029610477 scopus 로고
    • Review of the biology of quercetin and related bioflavonoids
    • Formica JV, Regelson W. 1995. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33 (12 1061 80.
    • (1995) Food Chem Toxicol , vol.33 , Issue.12 , pp. 1061-80
    • Formica, J.V.1    Regelson, W.2
  • 5
    • 0035964461 scopus 로고    scopus 로고
    • Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine
    • Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, Kadota T, Koda T, Nakamura M, Imaida K, Ito N, Shirai T. 2001. Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett 171 (1 17 25.
    • (2001) Cancer Lett , vol.171 , Issue.1 , pp. 17-25
    • Hagiwara, A.1    Miyashita, K.2    Nakanishi, T.3    Sano, M.4    Tamano, S.5    Kadota, T.6    Koda, T.7    Nakamura, M.8    Imaida, K.9    Ito, N.10    Shirai, T.11
  • 6
    • 18344394946 scopus 로고    scopus 로고
    • Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine
    • Hagiwara A, Yoshino H, Ichihara T, Kawabe M, Tamano S, Aoki H, Koda T, Nakamura M, Imaida K, Ito N, Shirai T. 2002. Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J Toxicol Sci 27 (1 57 68.
    • (2002) J Toxicol Sci , vol.27 , Issue.1 , pp. 57-68
    • Hagiwara, A.1    Yoshino, H.2    Ichihara, T.3    Kawabe, M.4    Tamano, S.5    Aoki, H.6    Koda, T.7    Nakamura, M.8    Imaida, K.9    Ito, N.10    Shirai, T.11
  • 8
    • 1642527133 scopus 로고    scopus 로고
    • Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system
    • Hokaiwado N, Asamoto M, Tsujimura K, Hirota T, Ichihara T, Satoh T, Shirai T. 2003. Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system. Cancer Sci 95 (2 123 30.
    • (2003) Cancer Sci , vol.95 , Issue.2 , pp. 123-30
    • Hokaiwado, N.1    Asamoto, M.2    Tsujimura, K.3    Hirota, T.4    Ichihara, T.5    Satoh, T.6    Shirai, T.7
  • 9
    • 0028814339 scopus 로고
    • Genetics and biochemistry of anthocyanin biosynthesis
    • Holton TA, Cornish EC. 1995. Genetics and biochemistry of anthocyanin biosynthesis. Plant Cell 7 (7 1071 83.
    • (1995) Plant Cell , vol.7 , Issue.7 , pp. 1071-83
    • Holton, T.A.1    Cornish, E.C.2
  • 10
    • 0037333332 scopus 로고    scopus 로고
    • Potential mechanisms of cancer chemoprevention by anthocyanins
    • Hou DX. 2003. Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 3 (2 149 59.
    • (2003) Curr Mol Med , vol.3 , Issue.2 , pp. 149-59
    • Hou, D.X.1
  • 11
    • 1642422882 scopus 로고    scopus 로고
    • Anthocyanidins inhibit activator protein 1 activity and cell transformation: Structure-activity relationship and molecular mechanisms
    • Hou DX, Kai K, Li JJ, Lin S, Terahara N, Wakamatsu M, Fujii M, Young MR, Colburn N. 2004. Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. Carcinogenesis 25 (1 29 36.
    • (2004) Carcinogenesis , vol.25 , Issue.1 , pp. 29-36
    • Hou, D.X.1    Kai, K.2    Li, J.J.3    Lin, S.4    Terahara, N.5    Wakamatsu, M.6    Fujii, M.7    Young, M.R.8    Colburn, N.9
  • 12
    • 0019254038 scopus 로고
    • The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide
    • Ito N, Tatematsu M, Nakanishi K, Hasegawa R, Takano T, Imaida K, Ogiso T. 1980. The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide. Gann 71 (6 832 42.
    • (1980) Gann , vol.71 , Issue.6 , pp. 832-42
    • Ito, N.1    Tatematsu, M.2    Nakanishi, K.3    Hasegawa, R.4    Takano, T.5    Imaida, K.6    Ogiso, T.7
  • 13
    • 0023858438 scopus 로고
    • Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - An approach for a new medium-term bioassay system
    • Ito N, Tatematsu M, Inoue T, Tagawa Y, Aoki T, Uwagawa S, Kagawa M, Ogiso T, Masui T, Imaida K, Fukushima S, Asamoto M. 1988. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - an approach for a new medium-term bioassay system. Carcinogenesis 9 (3 387 94.
    • (1988) Carcinogenesis , vol.9 , Issue.3 , pp. 387-94
    • Ito, N.1    Tatematsu, M.2    Inoue, T.3    Tagawa, Y.4    Aoki, T.5    Uwagawa, S.6    Kagawa, M.7    Ogiso, T.8    Masui, T.9    Imaida, K.10    Fukushima, S.11    Asamoto, M.12
  • 14
    • 0029873749 scopus 로고    scopus 로고
    • Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents
    • Ito N, Hasegawa R, Imaida K, Hirose M, Shirai T. 1996. Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents. Exp Toxicol Pathol 48 (2-3 113 9.
    • (1996) Exp Toxicol Pathol , vol.48 , Issue.23 , pp. 113-9
    • Ito, N.1    Hasegawa, R.2    Imaida, K.3    Hirose, M.4    Shirai, T.5
  • 15
    • 0034735888 scopus 로고    scopus 로고
    • Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells
    • Joshi SS, Kuszynski CA, Bagchi M, Bagchi D. 2000. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology 155 (1-3 83 90.
    • (2000) Toxicology , vol.155 , Issue.13 , pp. 83-90
    • Joshi, S.S.1    Kuszynski, C.A.2    Bagchi, M.3    Bagchi, D.4
  • 16
    • 39149143709 scopus 로고    scopus 로고
    • The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage
    • Kaindl U, Eyberg I, Rohr-Udilova N, Heinzle C, Marian B. 2008. The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage. Food Chem Toxicol 46 (4 1320 6.
    • (2008) Food Chem Toxicol , vol.46 , Issue.4 , pp. 1320-6
    • Kaindl, U.1    Eyberg, I.2    Rohr-Udilova, N.3    Heinzle, C.4    Marian, B.5
  • 17
    • 22444445229 scopus 로고    scopus 로고
    • Antioxidative activity of anthocyanins from purple sweet potato, Ipomoera batatas cultivar Ayamurasaki
    • Kano M, Takayanagi T, Harada K, Makino K, Ishikawa F. 2005. Antioxidative activity of anthocyanins from purple sweet potato, Ipomoera batatas cultivar Ayamurasaki. Biosci Biotechnol Biochem 69 (5 979 88.
    • (2005) Biosci Biotechnol Biochem , vol.69 , Issue.5 , pp. 979-88
    • Kano, M.1    Takayanagi, T.2    Harada, K.3    Makino, K.4    Ishikawa, F.5
  • 18
    • 0042889217 scopus 로고    scopus 로고
    • Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression
    • Kinoshita A, Wanibuchi H, Morimura K, Wei M, Shen J, Imaoka S, Funae Y, Fukushima S. 2003. Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis 24 (8 1389 99.
    • (2003) Carcinogenesis , vol.24 , Issue.8 , pp. 1389-99
    • Kinoshita, A.1    Wanibuchi, H.2    Morimura, K.3    Wei, M.4    Shen, J.5    Imaoka, S.6    Funae, Y.7    Fukushima, S.8
  • 20
    • 0031445788 scopus 로고    scopus 로고
    • Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo
    • Koide T, Hashimoto Y, Kamei H, Kojima T, Hasegawa M, Terabe K. 1997. Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo. Cancer Biother Radiopharm 12 (4 277 80.
    • (1997) Cancer Biother Radiopharm , vol.12 , Issue.4 , pp. 277-80
    • Koide, T.1    Hashimoto, Y.2    Kamei, H.3    Kojima, T.4    Hasegawa, M.5    Terabe, K.6
  • 21
    • 0034005479 scopus 로고    scopus 로고
    • Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: Regulation mechanism of the 8-OHdG level in DNA
    • Kondo S, Toyokuni S, Tanaka T, Hiai H, Onodera H, Kasai H, Imamura M. 2000. Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA. Clin Cancer Res 6 (4 1394 400.
    • (2000) Clin Cancer Res , vol.6 , Issue.4 , pp. 1394-400
    • Kondo, S.1    Toyokuni, S.2    Tanaka, T.3    Hiai, H.4    Onodera, H.5    Kasai, H.6    Imamura, M.7
  • 22
    • 0030596107 scopus 로고    scopus 로고
    • Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells
    • Kuo SM. 1996. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110 (1-2 41 8.
    • (1996) Cancer Lett , vol.110 , Issue.12 , pp. 41-8
    • Kuo, S.M.1
  • 23
    • 28444465215 scopus 로고    scopus 로고
    • Anthocyanins accumulation and related gene expression in red orange fruit induced by low temperature storage
    • Lo Piero AR, Puglisi I, Rapisarda P, Petrone G. 2005. Anthocyanins accumulation and related gene expression in red orange fruit induced by low temperature storage. J Agric Food Chem 53 (23 9083 8.
    • (2005) J Agric Food Chem , vol.53 , Issue.23 , pp. 9083-8
    • Lo Piero, A.R.1    Puglisi, I.2    Rapisarda, P.3    Petrone, G.4
  • 24
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett LJ. 2000. Oxyradicals and DNA damage. Carcinogenesis 21 (3 361 70.
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 361-70
    • Marnett, L.J.1
  • 25
    • 0029328461 scopus 로고
    • Anthocyanins in grapes and grape products
    • Mazza G. 1995. Anthocyanins in grapes and grape products. Crit Rev Food Sci Nutr 35 (4 341 71.
    • (1995) Crit Rev Food Sci Nutr , vol.35 , Issue.4 , pp. 341-71
    • Mazza, G.1
  • 26
    • 36849037908 scopus 로고    scopus 로고
    • Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels
    • Min K, Ebeler SE. 2007. Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. Food Chem Toxicol 46 (1 96 104.
    • (2007) Food Chem Toxicol , vol.46 , Issue.1 , pp. 96-104
    • Min, K.1    Ebeler, S.E.2
  • 27
    • 40049092280 scopus 로고    scopus 로고
    • Protective effects of a combination of quercetin and vitamin e against cyclosporine A-induced oxidative stress and hepatotoxicity in rats
    • Mostafavi-Pour Z, Zal F, Monabati A, Vessal M. 2008. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res 38 (4 385 92.
    • (2008) Hepatol Res , vol.38 , Issue.4 , pp. 385-92
    • Mostafavi-Pour, Z.1    Zal, F.2    Monabati, A.3    Vessal, M.4
  • 28
    • 0347758628 scopus 로고    scopus 로고
    • Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes
    • Nair HK, Rao KV, Aalinkeel R, Mahajan S, Chawda R, Schwartz SA. 2004. Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol 11 (1 63 9.
    • (2004) Clin Diagn Lab Immunol , vol.11 , Issue.1 , pp. 63-9
    • Nair, H.K.1    Rao, K.V.2    Aalinkeel, R.3    Mahajan, S.4    Chawda, R.5    Schwartz, S.A.6
  • 29
    • 34249882770 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    • Ramos S. 2007. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18 (7 427 42.
    • (2007) J Nutr Biochem , vol.18 , Issue.7 , pp. 427-42
    • Ramos, S.1
  • 30
    • 0034753487 scopus 로고    scopus 로고
    • Differential effects of partial hepatectomy and carbon tetrachloride administration on induction of liver cell foci in a model for detection of initiation activity
    • Sakai H, Tsukamoto T, Yamamoto M, Shirai N, Iidaka T, Yanai T, Masegi T, Tatematsu M. 2001. Differential effects of partial hepatectomy and carbon tetrachloride administration on induction of liver cell foci in a model for detection of initiation activity. Jpn J Cancer Res 92 (10 1018 25.
    • (2001) Jpn J Cancer Res , vol.92 , Issue.10 , pp. 1018-25
    • Sakai, H.1    Tsukamoto, T.2    Yamamoto, M.3    Shirai, N.4    Iidaka, T.5    Yanai, T.6    Masegi, T.7    Tatematsu, M.8
  • 31
    • 7044222915 scopus 로고    scopus 로고
    • Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats
    • Salim EI, Kaneko M, Wanibuchi H, Morimura K, Fukushima S. 2004. Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats. Food Chem Toxicol 42 (12 1949 69.
    • (2004) Food Chem Toxicol , vol.42 , Issue.12 , pp. 1949-69
    • Salim, E.I.1    Kaneko, M.2    Wanibuchi, H.3    Morimura, K.4    Fukushima, S.5
  • 32
    • 34247282876 scopus 로고    scopus 로고
    • Effects of dietary administration of plant-derived anthocyanin-rich colors to spontaneously hypertensive rats
    • Shindo M, Kasai T, Abe A, Kondo Y. 2007. Effects of dietary administration of plant-derived anthocyanin-rich colors to spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 53 (1 90 3.
    • (2007) J Nutr Sci Vitaminol (Tokyo) , vol.53 , Issue.1 , pp. 90-3
    • Shindo, M.1    Kasai, T.2    Abe, A.3    Kondo, Y.4
  • 33
    • 33644641285 scopus 로고    scopus 로고
    • The role of tea and tea flavonoids in cardiovascular health
    • Stangl V, Lorenz M, Stangl K. 2006. The role of tea and tea flavonoids in cardiovascular health. Mol Nutr Food Res 50 (2 218 28.
    • (2006) Mol Nutr Food Res , vol.50 , Issue.2 , pp. 218-28
    • Stangl, V.1    Lorenz, M.2    Stangl, K.3
  • 34
    • 19444377184 scopus 로고    scopus 로고
    • Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study
    • Straface E, Matarrese P, Gambardella L, Vona R, Sgadari A, Silveri MC, Malorni W. 2005. Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study. FEBS Lett 579 (13 2759 66.
    • (2005) FEBS Lett , vol.579 , Issue.13 , pp. 2759-66
    • Straface, E.1    Matarrese, P.2    Gambardella, L.3    Vona, R.4    Sgadari, A.5    Silveri, M.C.6    Malorni, W.7
  • 35
    • 0020964668 scopus 로고
    • Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats
    • Tatematsu M, Hasegawa R, Imaida K, Tsuda H, Ito N. 1983. Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats. Carcinogenesis 4 (4 381 6.
    • (1983) Carcinogenesis , vol.4 , Issue.4 , pp. 381-6
    • Tatematsu, M.1    Hasegawa, R.2    Imaida, K.3    Tsuda, H.4    Ito, N.5
  • 36
    • 0018898535 scopus 로고
    • Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens
    • Tsuda H, Lee G, Farber E. 1980. Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res 40 (4 1157 64.
    • (1980) Cancer Res , vol.40 , Issue.4 , pp. 1157-64
    • Tsuda, H.1    Lee, G.2    Farber, E.3
  • 37
    • 4644316078 scopus 로고    scopus 로고
    • Oxidative stress and its association with coronary artery disease and different atherogenic risk factors
    • Vassalle C, Petrozzi L, Botto N, Andreassi MG, Zucchelli GC. 2004. Oxidative stress and its association with coronary artery disease and different atherogenic risk factors. J Intern Med 256 (4 308 15.
    • (2004) J Intern Med , vol.256 , Issue.4 , pp. 308-15
    • Vassalle, C.1    Petrozzi, L.2    Botto, N.3    Andreassi, M.G.4    Zucchelli, G.C.5
  • 40
    • 0034660863 scopus 로고    scopus 로고
    • Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells
    • Wenzel U, Kuntz S, Brendel MD, Daniel H. 2000. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res 60 (14 3823 31.
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3823-31
    • Wenzel, U.1    Kuntz, S.2    Brendel, M.D.3    Daniel, H.4
  • 41
    • 33745512076 scopus 로고    scopus 로고
    • Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption
    • Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. 2006. Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54 (11 4069 75.
    • (2006) J Agric Food Chem , vol.54 , Issue.11 , pp. 4069-75
    • Wu, X.1    Beecher, G.R.2    Holden, J.M.3    Haytowitz, D.B.4    Gebhardt, S.E.5    Prior, R.L.6
  • 42
    • 27944509646 scopus 로고    scopus 로고
    • Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells
    • Zhang YM. 2005. Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicol Sci 88 (2 545 50.
    • (2005) Toxicol Sci , vol.88 , Issue.2 , pp. 545-50
    • Zhang, Y.M.1
  • 43
    • 0031921546 scopus 로고    scopus 로고
    • Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: Induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins
    • Zi X, Feyes DK, Agarwal R. 1998a. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins. Clin Cancer Res 4 (4 1055 64.
    • (1998) Clin Cancer Res , vol.4 , Issue.4 , pp. 1055-64
    • Zi, X.1    Feyes, D.K.2    Agarwal, R.3
  • 44
    • 0032080609 scopus 로고    scopus 로고
    • A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells
    • Zi X, Grasso AW, Kung HJ, Agarwal R. 1998b. A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res 58 (9 1920 9.
    • (1998) Cancer Res , vol.58 , Issue.9 , pp. 1920-9
    • Zi, X.1    Grasso, A.W.2    Kung, H.J.3    Agarwal, R.4


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