Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model

Chemico-Biological Interactions

Volumn 185, Issue 3, 2010, Pages 189-201

  Mizukami, Sayaka ^a   Ichimura, Ryohei ^a   Kemmochi, Sayaka ^a,b   Wang, Liyun ^a   Taniai, Eriko ^a   Mitsumori, Kunitoshi ^a   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Copper (Cu) overloading; Iron (Fe) overloading; Oxidative stress; Rat hepatocarcinogenesis; Tumor promotion

Indexed keywords

CERULOPLASMIN; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; DIETHYLNITROSAMINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M3; HEME OXYGENASE 1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IRON; MACROPHAGE INFLAMMATORY PROTEIN 2; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXIREDOXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOREDOXIN REDUCTASE 2; TRANSCRIPTION FACTOR NRF2; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; CARCINOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FOOD INTAKE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOREACTIVITY; IRON OVERLOAD; KUPFFER CELL; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER REGENERATION; LIVER TOXICITY; LIVER WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TUMOR PROMOTION; WEIGHT CHANGE; ANIMAL; CARCINOGEN TESTING; ENZYMOLOGY; FISCHER 344 RAT; IMMUNOHISTOCHEMISTRY; LIVER; LIVER TUMOR; MALE; METABOLISM; PATHOLOGY; TIME;

RATTUS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; COPPER; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; IRON; IRON OVERLOAD; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; RATS; RATS, INBRED F344; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

EID: 77952297713     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.023     Document Type: Article

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