Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia

European Surgical Research

Volumn 28, Issue 4, 1996, Pages 270-277

  Koeppel, Thomas A ^a   Thies, J C ^a   Lehmann, T ^a   Gebhard, M M ^a   Herfarth, C ^a   Otto, G ^a   Post, S ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Hepatic microcirculation; N Acetylcysteine; Reperfusion injury

Indexed keywords

ACETYLCYSTEINE;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; FLUORESCENCE MICROSCOPY; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ADHERENCE; LIVER CIRCULATION; LIVER ISCHEMIA; LIVER SINUSOID; MALE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT;

EID: 0029890763     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000129466     Document Type: Article

References (24)

1. Huguet C, Gavelli A, Chieco PA, Bona S, Harb J, Joseph JM, Jobard J, Gramaglia M, Lasscrre M: Liver ischemia for hepatic resection: Where is the limit? Surgery 1992;3: 251-259.
2. Vollmar B, Menger MD, Glasz J, Leiderer R, Messmer K: Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury, Am J Physiol 1994:267: G786-G793.
3. Vollmar B, Glasz J, Leiderer R, Post S, Menger MD: Hepatic nticrocircu-latory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion, Am J Pathol 1994:145:1421-1431.
4. Huguet C, Gavelli A, Bona S: Hepatic resection with ischemia of the liver exceeding one hour, J Am Coll Surg 1994;178:454-458.
5. Lin TY, Lee CS, Chen KM, Chen CC: Role of surgery in the treatment of primary carcinoma of the liver: A 31-year experience, Br J Surg 1987; 74:839-842.
6. Dunne JB, Davenport M, Williams R, Tredger JM: Evidence that S-adenosylntethionine and N-acctyl-cysteinc reduce injury from sequential cold and warm ischemia in the isolated perfused rat liver, Transplantation 1994:57:1161-1168.
7. Prescott LF, Illingworth RN, Critchley JAJH, Stewart MJ, Adam RD, Proudfoot AT: Intravenous N-ace-tylcysteinc: The treatment of choice for paracetamol poisoning, Br Med J 1979;2: 1097-1100.
8. Harrison PM, Wcndon JA, Gimson AES, Alexander GJM, Williams R: Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure, N Engl J Med 1991;324:1852-1857.
9. Borgström L, Kagedal B, Paulsen O: Pharmacokinetics of N-aceivlcys-teine in man, Eur J Clin Pharmacol 1986;31:217-222.
10. Kharazmi A, Nielsen H, Schiotz PO: N-Acetylcysteine inhibits human neutrophil and monocyte Chemotaxis and oxidative metabolism, Int J Immunopharmacol 1988; 10: 39-46.
11. Post S, Palma P, Rentsch M, Gonzalez AP, Menger M: DilTcrential impact of Carolina rinse and University of Wisconsin solution on microcirculation, leukocyte adhesion, Kupffer cell activity and biliary excretion after liver transplantation, Hepatology 1993;18:1490-1497.
12. Post S, Palma P, Gonzalez AP, Rentsch M, Menger MD: Timing of arterialization in liver transplantation, Ann Surg 1994;220:691-698.
13. Post S, Gonzalez AP, Palma P, Rcntsch M, Stiehl A, Mcngcr MD: Assessment of hepatic phagocytic activity by in vivo microscopy after liver transplantation in the rat, Hcp-atology 1992;16:803-809.
14. Bonamini L, Gazzaniga A: Toxico-logical, pharmacokinetic and metabolic studies on acetylcysteine, Eur J Respir Dis 1980:61 (suppl 111):45-51.
15. Jaeschkc H, Farhood A: Neutrophils contribute to ischemia-reperfusion injury in rat liver in vivo, FASEB J 1990:4:3355.
16. Steinhot TG, Bchrcnd M, Schrader B, Pichlmayr R: Intercellular immune adhesion molecules in human liver transplants: Overview on expression patterns of leukocyte receptor and ligand molecules, Hepatology 1993;18:440-453.
17. Gaboury JP, Anderson DC, Kubes P: Molecular mechanism involved in superoxide-induced leukocyte-endothelial cell interactions in vivo, Am J Physiol 1994:266:H637-H642.
18. Jaeschkc H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ: Complement activates Kupffcr cells and neutrophils during repcrfusion after hepatic ischemia, Am J Physiol 1993;246:G801-G809.
19. Vollmar B, Glasz J, Post S, Menger MD: Depressed phagocytic activity of Kupffer cells after warm ischemia-reperfusion of the liver, J Hepatol 1994:20/2:301-304.
20. Aruoma OI, Halliwell B, Hocy BM, Butler J: The antioxidanl action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypcchlorus acid, Free Radic Biol Med 1989:6: 593.
21. Jaeschkc H: Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo, Am J Physiol 1992;263:G60.
22. Waldmann SA, Murad F: Biochemical mechanisms underlying vascular smooth muscle relaxation: The gua-nylate cyclase-cyclic GMP system, J C'ardiovasc Pharmacol 1988:12 (suppl 5): 115-118.
23. Azuma H, Ishikawa M, Sekizaki S: Endothelium-dependent inhibition of platelet aggregation, Br J Pharmacol 1986:88:411-415.
24. Stamler J, Mendelsohn ME, Ama-rante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J: N-Acetyl-cysteine potentiates platelet inhibition by cndothclium-dcrived relaxing factor, Circ Res 1989:65:789-795.