Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis

Cancer Epidemiology Biomarkers and Prevention

Volumn 7, Issue 5, 1998, Pages 435-440

  Nair, Jagadeesan ^a   Carmichael, Paul L ^b   Fernando, R Charles ^a   Phillips, David H ^c   Strain, Alistair J ^d   Bartseh, Helmut ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,N6 ETHENODEOXYADENOSINE; 3,N4 ETHENODEOXYCYTIDINE; COPPER; DEOXYADENOSINE DERIVATIVE; DEOXYCYTIDINE; IRON; LIPID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; COPPER METABOLISM; DNA ADDUCT; DNA DAMAGE; HEMOCHROMATOSIS; HUMAN; HUMAN TISSUE; IRON STORAGE; LIPID PEROXIDATION; LIVER CARCINOMA; PRIORITY JOURNAL; WILSON DISEASE;

ADOLESCENT; ADULT; AGED; CHILD; COPPER; DEOXYADENOSINES; DNA; DNA ADDUCTS; FEMALE; HEMOCHROMATOSIS; HEPATOLENTICULAR DEGENERATION; HUMANS; INFANT, NEWBORN; IRON; LIPID PEROXIDATION; LIVER; MALE; METAL METABOLISM, INBORN ERRORS; MIDDLE AGED;

EID: 0031948085     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Tanzi, R. E., Petrukhin, K , Chernov, I., Pellequer, J. L , Wasco, W , Ross, B , Romano, D. M . Parano, E., Pavone, L., Brzustowicz, L. M , Devoto, M., Peppercorn, J , Bush, A. I., Sternlieb, I., Pirastu, M , Gusella, J F , Evgrafov, O., Penchaszadeh, G. K , Honig, B , Edelman, J. J , Soares, M B., Scheinberg, I. H., and Gilliam, T C. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene, Nat. Genet, 5: 344-350, 1993.
2. Petrukhin, K., Fischer, S. G., Pirastu, M., Tanzi, R. E., Chernov, I, Devoto, M , Brzustowicz, L. M., Cayanis, E., Vitale, E., Russo, J. J , Matseoane, D., Boukhgalter, B., Wasco, W., Figus, A. L., Loudianos, J , Cao, A., Sternlieb, I., Evgrafov, O., Parano, E., Pavone, L., Warburton, D., Ott, J., Penchaszadeh, G. K , Scheinberg, I H., and Gilliam, T C. Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet, 5: 338-343, 1993.
3. Bull, P. C , Thomas, G. R., Rommens, J. M , Forbes, J. R., and Cox, D. W. The Wilson disease gene is a putative copper transporting P-rype ATPase similar to the Menkes gene. Nat. Genet., 5: 327-337, 1993.
4. Mon, M., Hattori, A., Sawaki, M., Tsuzuki, N., Sawada, N., Oyamada, M., Sugawara, N., and Enomoto, K. The LEC rat a model for human hepatitis, liver cancer, and much more. Am J. Pathol , 144: 200-204, 1994
5. Yamaguchi, Y , Heiny, M. E., and Gitlin, J D. Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease. Biochem. Biophys, Res. Commun, 197: 271-277, 1993
6. Deugnier, Y. M., Loreal, O , Turlin, B , Gyuader, D., Jouanolle, H., Moirand, R , Jacquelinet, C., and Brissot, P. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology, 102: 2050-2059, 1992
7. Feder, J N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D A , Basava, A., Dormishian, F, Domingo, R., Jr., Ellis, M. C., Fullan, A , Hinton, L M., Jones, N L , Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D B., Mapa, F. A., McClellend, E., Meyer, N. C , Mintier, G. A., Moeller, N., Moore, T., Morikang, C. E., Prass, L., Quintana, L , Starnes, S. M., Schatzman, R C , Brunke, K. J . Drayna, D. T , Risch. N. J., Bacon, B. R , and Wolff. R. K A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat Genet. 13 399-408, 1996
8. Powell, L W Hemochromatosis the impact of early diagnosis and therapy. Gastroenterology. 110: 1304-1307, 1996
9. Bradbear, R. A , Bain, C., Siskind, V., Schofield, F D , Webb, S., Axelsen, E M , Halliday, J. W , Bassett, M. L., and Powell, L. W Cohort study of internal malignancy in genetic hemochromatosis and other chronic nonalcoholic liver diseases J. Natl. Cancer Inst., 75: 81-84, 1985
10. Niederau, C., Fischer, R., Sonnenberg, A , Stremmel, W., Trampisch, H J , and Strohmeyer, G. Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N. Engl. I Med , 313. 1256-1262, 1985.
11. Hsmg, A W., McLaughlin, J. K., Olsen, J. H., Mellemkjar, L., Wacholder, S., and Fraumeni, J. F., Jr Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J. Cancer, 60. 160-162, 1995
12. Ferenci, P , Gilliam. T C , Gitlin, J. D . Packman, S., Schilsky, M. L , Snkol, R J., and Sternlieb, I An international symposium on Wilson's and Menkes' diseases Hepatology, 24. 952-958, 1996.
13. Bonkovsky, H L , Ponka, P., Bacon, B. R., Drysdale, J , Grace, N. D., and Tavill, A. S. An update on iron metabolism: summary of the Fifth International Conference on Disorders of Iron Metabolism Hepatology, 24: 718-729, 1996.
14. Carmichael, P L., Hewer, A., Osborne, M. R , Strain, A. J., and Phillips, D. H. Detection of bulky DNA lesions in The liver of patients with Wilson's disease and primary haemochromatosis Mutat. Res., 326: 235-243, 1995.
15. Esterbauer, H. Estimation of peroxidative damage. A critical review. Pathol. Biol, 44: 25-28, 1996
16. 4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chem. Res. Toxicol, 8: 278-283, 1995.
17. Chen, H. J., and Chung, F L. Epoxidation of trans-4-hydroxy-2-nonenal by fatty acid hydroperoxides and hydrogen peroxide. Chem. Res Toxicol , 9: 306-312, 1996.
18. Nair, J., Sone, H., Nagao, M , Barbin, A., and Bartsch, H. Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma. Cancer Res., 56: 1267-1271, 1996.
19. Clinical Applications of Atomic Absorption/Emission Spectroscopy. Lexington, MA: Instrumentation Laboratory, Inc., 1972
20. 32P-postlabeling Carcinogenesis (Lond.), 16: 613-617, 1995.
21. 4-ethenocytosine in DNA In: D. H Phillips, M. Castegnaro, and H. Bartsch (eds ), Post-Labelling Methods for Detection of DNA Adducts, pp 263-269 Lyon, France: IARC, 1993
22. 4-etheno-2′-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride Carcinogenesis (Lond ), 10: 209-212, 1989.
23. Guichard, Y , El Ghissassi, F., Nair, J., Bartsch, H , and Barbin, A. Formation and accumulation of DNA ethenobases in adult Sprague-Dawley rats exposed to vinyl chloride Carcinogenesis (Lond ). 17: 1553-1559, 1996
24. 32P-postlabelling in liver and lung DNA of mice treated with ethyl carbamate (urethane) or its metabolites. Carcinogenesis (Lond ), 17: 1711-1718, 1996.
25. von Herbay, A , de Groot, H , Hegi, U., Stremmel, W., Strohmeyer, G , and Sies, H. Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease J Hepatol , 20: 41-46, 1994.
26. Sokol, R J , Devereaux, M , Mierau, G. W , Hambidge, K M., and Shikes, R H. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency. Gastroenterology, 99: 1061-1071, 1990
27. Sternlieb, I., Quintana, N., Volenberg, L, and Schilsky, M. L. An array of mitochondrial alterations in the hepatocytes of Long-Evans cinnamon rats Hepatology, 22; 1782-1787, 1995.
28. Sokol, R. J , Twedt, D , McKim, J. M , Jr. Devereaux, M. W., Karrer, F M , Kam, I , von Steigmann, G., Narkewicz, M R , Bacon, B R , Britton, R. S , and Neuschwandertetri, B A Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroemerology, 107: 1788-1798, 1994.
29. Toyokuni, S. Iron-induced Carcinogenesis: the role of redox regulation. Free Radical Biol. Med., 20: 553-566, 1996
30. Stemlieb, I. Copper and the liver Gastroenterology, 78: 1615-1628, 1980
31. Halliwell, B , Gutteridge, J-M., and Cross C E Free radicals, antioxidants, and human disease, where are we now? J Lab. Clin Med , 119: 598-620, 1992.
32. Popper, H., Goldfischer, S , Sternlieb, I., Nayak, N. C., and Madhavan, T. V Cytoplasmic copper and its toxic effects. Studies in Indian childhood cirrhosis. Lancet, I. 1205-1208, 1979.
33. Pimentel, J. C., and Menezes, A P Liver disease in vineyard sprayers. Gastroenterology, 72: 275-283, 1977.
34. Wriggleworth, J. M , and Baum, H The biochemical function of iron. In: A. Jacobs and M. Worwood (eds ), Iron in Biochemistry and Medicine, pp 29-86. London: Academic Press, 1980.
35. Bartsch, H., Barbin, A., Marion, M J , Nair, J., and Guichard, Y. Formation, detection, and role in carcinogenesis of ethenobases in DNA. Drug Metab Rev., 26: 349-371, 1994.
36. Laplanche, A , Clavel Chapelon, F., Contassot, J. C., and Lanouziere, C. Exposure to vinyl chloride monomer: results of a cohort study after a seven-year follow-up The French VCM Group. Br. J Ind Med., 49: 134-137, 1992.
37. Ishak, K J Malignant mesenchyrnal tumors of the liver. In: K. Okuda and K. J Ishak (eds.), Neoplasm of the Liver, pp. 159-175, Tokyo: Springer-Verlag, 1987.
38. 4-ethano2′-deoxycytidinc, and 3-(2-hydroxyethyl)-2′-deoxyuridine. Chem Res. Toxicol., 8: 157-163, 1995.
39. Marion, M. J , Froment, O , and Trepo, C. Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure Mol. Carcinog., 4: 450-454, 1991.
40. Hellstein, M , Marion, M. J., Lehman, T., Welsh, J., Harris, C. C., MartelPlanche, G., Kusters, I., and Montesano, R. p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis (Lond.), 15: 1-3, 1994.
41. Barbin, A., Froment, O , Boivin, S., Marion, M-J , Belpoggi, F., Maltoni, C., and Montesano, R. p53 gene mutation pattern in rat liver tumors induced by vinyl chloride. Cancer Res , 57: 1695-1698, 1997
42. 4-ethenocytosine arc excised by separate human DNA glycosylases. Carcinogenesis (Lond ). 17 155-157, 1996.