Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells

Toxicologic Pathology

Volumn 30, Issue 4, 2002, Pages 435-451

  Morgan, Kevin T ^a   Ni, Hong ^b   Brown, H Roger ^b   Yoon, Lawrence ^b   Qualls, Charles W ^b   Crosby, Lynn M ^c   Reynolds, Randall ^b   Gaskill, Betty ^b   Anderson, Steven P ^b   Kepler, Thomas B ^d   Brainard, Tracy ^b   Liv, Nik ^b   Easton, Marilyn ^b   Merrill, Christine ^b   Creech, Don ^b   Sprenger, Dirk ^b   Conner, Gary ^b   Johnson, Paul R ^b   Fox, Tony ^b   Sartor, Maureen ^b   Richard, Erika ^b   Kuruvilla, Sabu ^b   Casey, Warren ^b   Benavides, Gina ^b   more..

^a Aventis Pharmaceuticals   (United States)

^b GLAXOSMITHKLINE   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d SANTA FE INSTITUTE   (United States)

Author keywords

cDNA arrays; Gene expression; GSH:GSSG; Hep G2 cells; Oxidative stress; RT PCR; Toxicity screen; Transcriptomics

Indexed keywords

ALLOXAN; BUTHIONINE SULFOXIMINE; COMPLEMENTARY DNA; CYCLOHEXIMIDE; CYTOCHROME P450 1A1; DIMETHYL SULFOXIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); DODECYL SULFATE; DOXORUBICIN; FLUORIDE SODIUM; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; MALEIC ACID DIETHYL ESTER; OUABAIN; POTASSIUM BROMATE; PROTEIN P21; SODIUM SELENITE; TOLBUTAMIDE; TOXIC SUBSTANCE;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA DAMAGE; DNA MICROARRAY; GENE EXPRESSION; HEAT STRESS; HUMAN; HUMAN CELL; INTERNET; LINEAR REGRESSION ANALYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; STATISTICAL ANALYSIS; TOXICOLOGY; DOSE RESPONSE; DRUG EFFECT; METHODOLOGY;

DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMAN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOXICOLOGY; TUMOR CELLS, CULTURED; HUMANS;

STROPHANTHUS GRATUS;

EID: 0036628949     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230290105613     Document Type: Article

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