Therapeutic approaches for ischemia/reperfusion injury in the liver

Journal of Molecular Medicine

Volumn 77, Issue 8, 1999, Pages 577-592

  Fan, Chenguang ^a   Zwacka, Ralf M ^b   Engelhardt, John F ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

AP 1; Gene therapy; Ischemia Reperfusion; Liver; NF B; Reactive oxygen species; Signal transduction; Superoxide dismutase

Indexed keywords

CATALASE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; XANTHINE OXIDASE;

CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER ISCHEMIA; ORGAN TRANSPLANTATION; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; REOXYGENATION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; SURGICAL TECHNIQUE;

EID: 0032881237     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001099900029     Document Type: Review

References (162)

1. 1. Szabo A, Heemann U (1998) Ischemia reperfusion injury and chronic allograft rejection. Transplant Proc 30:4281-4284
2. 2. Hammerman C, Kaplan M (1998) Ischemia and reperfusion injury. The ultimate pathophysiologic paradox. Clin Perinatol 25:757-777
3. 3. Lowes JR, Hubscher SG, Neuberger JM (1993) Chronic rejection of the liver allograft. Gastroenterol Clin North Am 22:401-420
4. 4. Shaw BW Jr (1995) Auxiliary liver transplantation for acute liver failure. Liver Transplant Surg 1:194-200
5. 5. Zwacka RM, Zhang Y, Halldorson J, Schlossberg H, Dudus L, Engelhardt JF (1997) CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. J Clin Invest 100:279-289
6. 6. Jacschke H, Bautista AP, Spolarics Z, Spitzer JJ (1991) Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic Res Commun 15:277-284
7. 7. Koo A, Komatsu H, Tao G, Inoue M, Guth PH, Kaplowitz N (1992) Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion. Hepatology 15:507-514
8. 8. Rauen U, Viebahn R, Lauchart W, de Groot H (1994) The potential role of reactive oxygen species in liver ischemia/reperfusion injury following liver surgery. Hepatogastroenterology 41:333-336
9. 9. Parks DA, Granger DN (1988) Ischemia-reperfusion injury: a radical view. Hepatology 8:680-682
10. 10. Richter C, Gogvadze V, Laffranchi R, Schlapbach R, Schweizer M, Suter M, Walter P, Yaffee M (1995) Oxidants in mitochondria: from physiology to diseases. Biochim Biophys Acta 1271:67-74
11. 11. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN (1987) Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 253:H699-H703
12. 12. Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA (1996) Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226
13. 13. Flaherty JT, Weisfeldt ML (1988) Reperfusion injury. Free Radic Biol Med 5:409-419
14. 14. Ghezzi P, Dinarello CA, Bianchi M, Rosandich ME, Repine JE, White CW (1991) Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cytokine 3:189-194
15. 15. Zhou W, McCollum MO, Levine BA, Olson MS (1992) Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. Hepatology 16:1236-1240
16. 16. Scoazec JY, Durand F, Degott C, Delautier D, Bernuau J, Belghiti J, Benhamou JP, Feldmann G (1994) Expression of cytokine-dependent adhesion molecules in postreperfusion biopsy specimens of liver allografts. Gastroenterology 107: 1094-1102
17. 17. Jaeschke H, Farhood A (1991) Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 260:G355-G362
18. 18. Liu P, McGuire GM, Fisher MA, Farhood A, Smith CW, Jaeschke H (1995) Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. Shock 3:56-62
19. 19. Churchill TA, Cheetham KM, Fuller BJ (1994) Glycolysis and energy metabolism in rat liver during warm and cold ischemia: evidence of an activation of the regulatory enzyme phosphofructokinase. Cryobiology 31:441-452
20. 20. Baumann M, Bender E, Stommer G, Gross G, Brand K (1989) Effects of warm and cold ischemia on mitochondrial functions in brain, liver and kidney. Mol Cell Biochem 87:137-145
21. 21. Mochida S, Arai M, Ohno A, Masaki N, Ogata I, Fujiwara K (1994) Oxidative stress in hepatocytes and stimulatory state of Kupffer cells after reperfusion differ between warm and cold ischemia in rats. Liver 14:234-240
22. 22. Ikeda T, Yanaga K, Kishikawa K, Kakizoe S, Shimada M, Sugimachi K (1992) Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats. Hepatology 16:454-461
23. 23. Saugstad OD, Aasen AO (1980) Plasma hypoxanthine concentrations in pigs. A prognostic aid in hypoxia. Eur Surg Res 12:123-129
24. 24. Saugstad OD (1996) Role of xanthine oxidase and its inhibitor in hypoxia: reoxygenation injury. Pediatrics 98:103-107
25. 25. Harris CM, Massey V (1997) The oxidative half-reaction of xanthine dehydrogenase with NAD; reaction kinetics and steady-state mechanism. J Biol Chem 272:28335-28341
26. 26. Stirpe F, Della Corte E (1969) The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem 244:3855-3863
27. 27. Saugstad OD (1988) Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 23:143-150
28. 28. Saugstad OD, Hallman M, Abraham JL, Epstein B, Cochrane C, Gluck L (1984) Hypoxanthine and oxygen induced lung injury: a possible basic mechanism of tissue damage? Pediatr Res 18:501-504
29. 29. Adkison D, Hollwarth ME, Benoit JN, Parks DA, McCord JM, Granger DN (1986) Role of free radicals in ischemia-reperfusion injury to the liver. Acta Physiol Scand Suppl 548:101-107
30. 30. Higuchi M, Aggarwal BB, Yeh ET (1997) Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function. J Clin Invest 99:1751-1758
31. 31. Quillet-Mary A, Jaffrezou JP, Mansat V, Bordier C, Naval J, Laurent G (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem 272:21388-21395
32. 32. Singh T (1996) Mammalian peroxisomes: metabolism of oxygen and reactive oxygen species. Ann N Y Acad Sci 804:612-627
33. 33. Simpson AE (1997) The cytochrome P450 4 (CYP4) family. Gen Pharmacol 28:351-359
34. 34. Wanders RJ, Denis S (1992) Identification of superoxide dismutase in rat liver peroxisomes. Biochim Biophys Acta 1115:259-262
35. 35. Pahan K, Smith BT, Singh AK, Singh I (1997) Cytochrome P450 2E1 in rat liver peroxisomes: downregulation by ischemia/reperfusion-induced oxidative stress. Free Radic Biol Med 23:963-971
36. 36. Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM (1991) Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254:1512-1515
37. 37. Simpson PJ, Lucchesi BR (1987) Free radicals and myocardial ischemia and reperfusion injury. J Lab Clin Med 110:13-30
38. 38. Pardini RS (1995) Toxicity of oxygen from naturally occurring redox-active pro-oxidants. Arch Insect Biochem Physiol 29:101-118
39. 39. Losser MR, Payen D (1996) Mechanisms of liver damage. Semin Liver Dis 16:357-367
40. 40. Kurokawa T, Nonami T, Harada A, Nakao A, Takagi H (1996) Mechanism and prevention of ischemia-reperfusion injury of the liver. Semin Surg Oncol 12:179-182
41. 41. Jaeschke H (1991) Reactive oxygen and ischemia/reperfusion injury of the liver. Chem Biol Interact 79:115-136
42. 42. Shito M, Wakabayashi G, Ueda M, Shimazu M, Shirasugi N, Endo M, Mukai M, Kitajimu M (1997) Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation 63:143-148
43. 43. Colletti LM, Cortis A, Lukacs N, Kunkel SL, Green M, Strieter RM (1998) Tumor necrosis factor up-regulates intercellular adhesion molecule 1, which is important in the neutrophil-dependent lung and liver injury associated with hepatic ischemia and reperfusion in the rat. Shock 10:182-191
44. 44. Van Damme J, Wuyts A, Froyen G, Van Coillie E, Struyf S, Billiau A, Proost P, Wang JM, Opdenakker G (1997) Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage. J Leukoc Biol 62:563-569
45. 45. Frangogiannis NG, Lindsey ML, Michael LH, Youker KA, Bressler RB, Mendoza LH, Spengler RN, Smith CW, Entman ML (1998) Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circulation 98:699-710
46. 46. Serizawa A, Nakamura S, Suzuki, Baba S, Nakano M (1996) Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. Hepatology 23:1656-1663
47. 47. Bacon KB, Premack BA, Gardner P, Schall TJ (1995) Activation of dual T cell signaling pathways by the chemokine RANTES. Science 269:1727-1730
48. 48. Bassendine MF, Jones DE, Yeaman SJ (1997) Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis. Semin Liver Dis 17:49-60
49. 49. Gauthier TW, Davenpeck KL, Lefer AM (1994) Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am J Physiol 267:G562-G568
50. 50. Kurose I, Saito H, Miura S, Ebinuma H, Higuchi H, Watanabe N, Zeki S, Nakamura T, Takaishi M, Ishii H (1997) CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. J Clin Invest 99:867-878
51. 51. Liu P, Yin K, Nagele R, Wong PY (1998) Inhibition of nitric oxide synthase attenuates peroxynitrite generation, but augments neutrophil accumulation in hepatic ischemia-reperfusion in rats. J Pharmacol Exp Ther 284:1139-1146
52. 52. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 87:1620-1624
53. 53. Szabo C (1996) The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6:79-88
54. 54. Marletta MA (1993) Nitric oxide synthase structure and mechanism. J Biol Chem 268:12231-12234
55. 55. Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr (1998) Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A 95:9220-9225
56. 56. Palmer HJ, Paulson KE (1997) Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 55:353-361
57. 57. Calzi ML, Raviolo C, Ghibaudi E, de Gioia L, Salmona M, Cazzaniga G, Kurosaki M, Terao M, Garattini E (1995) Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase. J Biol Chem 270:31037-31045
58. 58. Schreck R, Rieber P, Baeuerle PA (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 10:2247-2258
59. 59. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA (1992) Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 175:1181-1194
60. 60. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA (1997) Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25:1128-1135
61. 61. Zwacka RM, Zhang Y, Zhou W, Halldorson J, Engelhardt JF (1998) Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation. Hepatology 28:1022-1030
62. 62. Baeuerle PA, Henkel T (1994) Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141-179
63. 63. Taub R (1998) Blocking NF-kappaB in the liver: the good and bad news. Hepatology 27:1445-1446
64. 64. Baichwal VR, Baeuerle PA (1997) Activate NF-kappa B or die? Curr Biol 7:R94-R96
65. 65. Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA (1991) Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science 251:1490-1493 (published erratum 254:11)
66. 66. Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D (1990) Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell 62:1019-1029
67. 67. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S (1995) Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 9:2723-2735
68. 68. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (1997) Identification and characterization of an IkappaB kinase. Cell 90:373-383
69. 69. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91:243-252
70. 70. Grimm S, Baeuerle PA (1993) The inducible transcription factor NF-kappa B: structure-function relationship of its protein subunits. Biochem J 290:297-308
71. 71. Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H, Okumura K (1998) Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci USA 95: 3537-3542
72. 72. Lee FS, Peters RT, Dang LC, Maniatis T (1998) MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proc Natl Acad Sci U S A 95:9319-9324
73. 73. Lee FS, Hagler J, Chen ZJ, Maniatis T (1997) Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213-222
74. 74. Koong AC, Chen EY, Giaccia AJ (1994) Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 54:1425-1430
75. 75. Imbert V, Rupee RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Baeuerle PA, Peyron JF (1996) Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86:787-798
76. 76. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87:565-576
77. 77. Wang CY, Mayo MW, Baldwin AS Jr (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274:784-787
78. 78. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA (1998) NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 101:802-811 (published erratum 101:1541)
79. 79. Zwacka RM, Zhou W, Zhang Y, Darby CJ, Dudus L, Halldorson J, Oberley L, Engelhardt JF (1998) Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-kappaB activation. Nat Med 4:698-704
80. 80. Bach FH, Ferran C, Soares M, Wrighton CJ, Anrather J, Winkler H, Robson SC, Hancock WW (1997) Modification of vascular responses in xenotransplantation: inflammation and apoptosis. Nat Med 3:944-948
81. 81. Karin M, Liu Z, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240-246
82. 82. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA (1994) Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A 91:6030-6034
83. 83. Rutberg SE, Saez E, Lo S, Jang SI, Markova N, Spiegelman BM, Yuspa SH (1997) Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters. Oncogene 15:1337-1346
84. 84. Malliri A, Symons M, Hennigan RF, Hurlstone AF, Lamb RF, Wheeler T, Ozanne BW (1998) The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells. J Cell Biol 143:1087-1099
85. 85. Lakshminarayanan V, Drab-Weiss EA, Roebuck KA (1998) H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells. J Biol Chem 273:32670-32678
86. 86. Xu S, Cobb MH (1997) MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem 272:32056-32060
87. 87. Derijard B, Hibi M, Wu TH, Barrett T, Su B, Deng T, Karin M, Davis RJ (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037
88. 88. Sluss HK, Barrett T, Derijard B, Davis RJ (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 14:8376-8384
89. 89. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M (1991) Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354:494-496
90. 90. Whitmarsh AJ, Davis RJ (1996) Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74:589-607
91. 91. Thanos D, Maniatis T (1995) Identification of the rel family members required for virus induction of the human beta interferon gene. Mol Cell Biol 15:152-164
92. 92. Mizukami Y, Yoshioka K, Morimoto S, Yoshida K (1997) A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. J Biol Chem 272:16657-16662
93. 93. Colotta F, Polentarutti N, Sironi M, Mantovani A (1992) Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 267:18278-18283
94. 94. Schlossberg H, Zhang Y, Dudus L, Engelhardt JF (1996) Expression of c-fos and c-jun during hepatocellular remodeling following ischemia/reperfusion in mouse liver. Hepatology 23:1546-1555
95. 95. Westwick JK, Weitzel C, Leffert HL, Brenner DA (1995) Activation of Jun kinase is an early event in hepatic regeneration. J Clin Invest 95:803-810
96. 96. Bruccoleri A, Gallucci R, Germolec DR, Blackshear P, Simeonova P, Thurman RG, Luster MI (1997) Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology 25:133-141
97. 97. Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, Yaniv M (1994) Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76:747-760
98. 98. Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204
99. 99. Thanos D, Maniatis T (1995) NF-kappa B: a lesson in family values. Cell 80:529-532
100. 100. Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647
101. 101. Norris ML, Millhorn DE (1995) Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270:23774-23779
102. 102. Bunn HF, Poyton RO (1996) Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839-885
103. 103. Guillemin K, Krasnow MA (1997) The hypoxic response: huffing and HIFing. Cell 89:9-12
104. 104. Polla BS, Bonventre JV, Krane SM (1988) 1,25-Dihydroxy-vitamin D3 increases the toxicity of hydrogen peroxide in the human monocytic line U937: the role of calcium and heat shock. J Cell Riol 107:373-380
105. 105. Su CY, Chong KY, Owen OE, Dillmann WH, Chang C, Lai CC (1998) Constitutive and inducible hsp70 s are involved in oxidative resistance evoked by heat shock or ethanol. J Mol Cell Cardiol 30:587-598
106. 106. Polla BS, Stubbe H, Kantengwa S, Maridonneau-Parini I, Jacquier-Sarlin MR (1995) Differential induction of stress proteins and functional effects of heat shock in human phagocytes. Inflammation 19:363-378
107. 107. Polla BS, Kantengwa S, Francois D, Salvioli S, Franceschi C, Marsac C, Cossarizza A (1996) Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc Natl Acad Sci U S A 93:6458-6463
108. 108. Tacchini L, Radice L, Pogliaghi G, Bernelli-Zazzera A (1997) Differential activation of heat shock and nuclear factor kappaB transcription factors in postischemic reperfused rat liver. Hepatology 26:186-191
109. 109. Kelly KJ, Williams WW Jr, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV (1996) Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97:1056-1063
110. 110. Qayumi KA, English JC, Feelry EJ, Poostizadeh A, Nikbakht-Sangari M (1997) A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. Cardiovasc Drugs Ther 11:777-785
111. 111. Riera M, Torras J, Herrero I, Valles J, Paubert-Braquet M, Cruzado JM, Alsina J, Grinyo JM (1997) Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist. J Pharmacol Exp Ther 280:786-794
112. 112. Seekamp A, Warren JS, Remick DG, Till GO, Ward PA (1993) Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury. Am J Pathol 143:453-463
113. 113. Schreiber SL, Crabtree GR (1992) The mechanism of action of cyclosporin A and FK506. Immunol Today 13:136-142
114. 114. Dhar DK, Nagasue N, Kimoto T, Uchida M, Takemoto Y, Nakamura T (1992) The salutary effect of FK506 in ischemia-reperfusion injury of the canine liver. Transplantation 54:583-588
115. 115. von Ruecker AA, Wild M, Rao GS, Bidlingmaier F (1989) Atrial natriuretic peptide protects hepatocytes against damage induced by hypoxia and reactive oxygen. Possible role of intracellular free ionized calcium. J Clin Chem Clin Biochem 27:531-537
116. 116. Pellav R (1991) The protective effect of atrial natriuretic peptide (ANP) on cells damaged by oxygen radicals is mediated through elevated CGMP-levels, reduction of calcium-inflow and probably G-proteins. Biochem Biophys Res Commun 174:549-555
117. 117. Bilzer M, Helmberger T (1998) Images in hepatology: hepatic iron in hemochromatosis enhances hepatocellular carcinoma in magnetic resonance imaging. J Hepatol 28:523
118. 118. Belzer FO, Southard JH (1988) Principles of solid-organ preservation by cold storage. Transplantation 45:673-676
119. 119. Clavien PA (1998) Sinusoidal endothelial cell injury during hepatic preservation and reperfusion. Hepatology 28:281-285
120. 120. Li C, Browder W, Kao RL (1999) Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol 276:H543-H552
121. 121. Lesnefsky EJ, Dauber IM, Horwitz LD (1991) Myocardial sulfhydryl pool alterations occur during reperfusion after brief and prolonged myocardial ischemia in vivo. Circ Res 68:605-613
122. 122. Samuni A, Mitchell JB, DeGraff W, Krishna CM, Samuni U, Russo A (1991) Nitroxide SOD-mimics: modes of action. Free Radic Res Commun 12-13:187-194
123. 123. Sherman L, Dafni N, Lieman-Hurwitz J, Groner Y (1983) Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA. Proc Natl Acad Sci U S A 80:5465-5469
124. 124. Ho YS, Crapo JD (1988) Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. FEBS Lett 229:256-260
125. 125. Hjalmarsson K, Marklund SL, Engstrom A, Edlund T (1987) Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase. Proc Natl Acad Sci U S A 84:6340-6344
126. 126. Gorecki M, Beck Y, Hartman JR, Fischer M, Weiss L, Tochner Z, Slavin S, Nimrod A (1991) Recombinant human superoxide dismutases: production and potential therapeutical uses. Free Radic Res Commun 12-13:401-410
127. 127. Dougall WC, Nick HS (1991) Manganese superoxide dismutase: a hepatic acute phase protein regulated by interleukin-6 and glucocorticoids. Endocrinology 129:2376-2384
128. 128. Mallery SR, Landwehr DJ, Ness GM, Clark YM, Hohl CM (1998) Thiol redox modulation of tumor necrosis factor-alpha responsiveness in cultured AIDS-related Kaposi's sarcoma cells. J Cell Biochem 68:339-354
129. 129. De Leo ME, Landriscina M, Palazzotti B, Borrello S, Galeotti T (1997) Iron modulation of LPS-induced manganese superoxide dismutase gene expression in rat tissues. FEBS Lett 403:131-135
130. 130. Fernandez V, Videla LA (1996) Biochemical aspects of cellular antioxidant systems. Biol Res 29:177-182
131. 131. Michiels C, Raes M, Toussaint O, Remacle J (1994) Importance of Se-glutathione peroxidase, catalase, Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 17:235-248
132. 132. Mizoe A, Kondo S, Azuma T, Fujioka H, Tanaka K, Hashida M, Kanematsu T (1997) Preventive effects of superoxide dismutase derivatives modified with monosaccharides on reperfusion injury in rat liver transplantation. J Surg Res 73: 160-165
133. 133. Greenwald RA (1990) Superoxide dismutase and catalase as therapeutic agents for human diseases. A critical review. Free Radic Biol Med 8:201-209
134. 134. Turrens JF, Crapo JD, Freeman BA (1984) Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest 73:87-95
135. 135. Walther FJ, David-Cu R, Lopez SL (1995) Antioxidant-surfactant liposomes mitigate hyperoxic lung injury in premature rabbits. Am J Physiol 269:L613-L617
136. 136. Tang G, White JE, Gordon RJ, Lumb PD, Tsan MF (1993) Polyethylene glycol-conjugated superoxide dismutase protects rats against oxygen toxicity. J Appl Physiol 74:1425-1431
137. 137. Fujita T, Furitsu H, Nishikawa M, Takakura Y, Sezaki H, Hashida M (1992) Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion. Biochem Biophys Res Commun 189:191-196
138. 138. Inoue M, Watanabe N, Utsumi T, Sasaki J (1991) Targeting SOD by gene and protein engineering and inhibition of free radical injury. Free Radic Res Commun 12-13:391-399
139. 139. Tanswell AK, Freeman BA (1995) Antioxidant therapy in critical care medicine. New Horiz 3:330-341
140. 140. Yabe Y, Nishikawa M, Tamada A, Takakura Y, Hashida M (1999) Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives. J Pharmacol Exp Ther 289:1176-1184
141. 141. Melendez JA, Baglioni C (1992) Reduced expression of manganese superoxide dismutase in cells resistant to cytolysis by tumor necrosis factor. Free Radic Biol Med 12:151-159
142. 142. St. Clair DK, Oberley TD, Ho YS (1991) Overproduction of human Mn-superoxide dismutase modulates paraquat-mediated toxicity in mammalian cell., FEBS Lett 293:199-203
143. 143. Hirose K, Longo DL, Oppenheim JJ, Matsushima K (1993) Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation. Faseb J 7:361-368
144. 144. Russell WJ, Ho YS, Parish G, Jackson RM (1995) Effects of hypoxia on MnSOD expression in mouse lung. Am J Physiol 269:L221-L226
145. 145. Valentine JF, Nick HS (1992) Acute-phase induction of manganese superoxide dismutase in intestinal epithelial cell lines. Gastroenterology 103:905-912
146. 146. Danel C, Erzurum SC, Prayssac P, Eissa NT, Crystal RG, Herve P, Baudet B, Mazmanian M, Lemarchand P (1998) Gene therapy for oxidant injury-related diseases: adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia-reperfusion lung injury. Hum Gene Ther 9:1487-1496
147. 147. Horie Y, Wolf R, Flores SC, McCord JM, Epstein CJ, Granger DN (1998) Transgenic mice with increased copper/zinc-superoxide dismutase activity are resistant to hepatic leukostasis and capillary no-reflow after gut ischemia/reperfusion. Circ Res 83:691-696
148. 148. Deshmukh DR, Mirochnitchenko O, Ghole VS, Agnese D, Shah PC, Reddell M, Brolin RE, Inouye M (1997) Intestinal ischemia and reperfusion injury in transgenic mice overexpressing copper-zinc superoxide dismutase. Am J Physiol 273:C1130-C1135
149. 149. Mignotte B, Vayssiere JL (1998) Mitochondria and apoptosis. Eur J Biochem 252:1-15
150. 150. Kroemer G, Dallaporta B, Resche-Rigon M (1998) The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60:619-642
151. 151. Packer MA, Murphy MP (1994) Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A. FEBS Lett 345:237-240
152. 152. Costantini P, Petronilli V, Colonna R, Bernardi P (1995) On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide. Toxicology 99:77-88
153. 153. Beatrice MC, Stiers DL, Pfeiffer DR (1984) The role of glutathione in the retention of Ca2+ by liver mitochondria. J Biol Chem 259:1279-1287
154. 154. Halestrap AP, Kerr PM, Javadov S, Woodfield KY (1998) Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta 1366:79-94
155. 155. Ueda S, Nakamura H, Masutani H, Sasada T, Yonehara S, Takabayashi A, Yamaoka Y, Yodoi J (1998) Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c. J Immunol 161:6689-6695
156. 156. de Moissac D, Mustapha S, Greenberg AH, Kirshenbaum LA (1998) Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha. J Biol Chem 273:23946-23951
157. 157. Lawrence MS, McLaughlin JR, Sun GH, Ho DY, McIntosh L, Kunis DM, Sapolsky RM, Steinberg GK (1997) Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke. J Cereb Blood Flow Metab 17:740-744
158. 158. Li N, Karin M (1998) Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A 95:13012-13017
159. 159. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA (1998) Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology 27:1285-1295
160. 160. Stancovski I, Baltimore D (1997) NF-kappaB activation: the I kappaB kinase revealed? Cell 91:299-302
161. 161. Montaner S, Perona R, Saniger L, Lacal JC (1998) Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. J Biol Chem 273:12779-12785
162. 162. Cano E, Mahadevan LC (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122