-
1
-
-
3943102116
-
Unraveling the mechanisms involved in motor neuron degeneration in ALS
-
Bruijn LI, Miller TM, Cleveland DW. Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci. 2004;27:723–749.
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 723-749
-
-
Bruijn, LI1
Miller, TM2
Cleveland, DW.3
-
2
-
-
8844233445
-
Complex genetics of amyotrophic lateral sclerosis
-
Kunst CB. Complex genetics of amyotrophic lateral sclerosis. Am J Hum Genet. 2004;75:933–947.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 933-947
-
-
Kunst, CB.1
-
3
-
-
33747605320
-
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
-
Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006;7:710–723.
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 710-723
-
-
Pasinelli, P1
Brown, RH.2
-
4
-
-
0029838035
-
Neuropathology of ALS: an overview
-
Hirano A. Neuropathology of ALS: an overview. Neurology. 1996;47: S63–S66.
-
(1996)
Neurology
, vol.47
, pp. S63-S66
-
-
Hirano, A.1
-
5
-
-
38449102667
-
Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease
-
Buratti E, Baralle FE. Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. Front Biosci. 2008;13: 867–878.
-
(2008)
Front Biosci
, vol.13
, pp. 867-878
-
-
Buratti, E1
Baralle, FE.2
-
6
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314:130–133.
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M1
Sampathu, DM2
Kwong, LK3
-
7
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Arai T, Hasegawa M, Akiyama H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006;351:602–611.
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 602-611
-
-
Arai, T1
Hasegawa, M2
Akiyama, H3
-
9
-
-
54049140363
-
The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis
-
Strong MJ. The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008;9:323–338.
-
(2008)
Amyotroph Lateral Scler
, vol.9
, pp. 323-338
-
-
Strong, MJ.1
-
10
-
-
67651160559
-
Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
-
Strong MJ, Grace GM, Freedman M, et al. Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009;10: 131–146.
-
(2009)
Amyotroph Lateral Scler
, vol.10
, pp. 131-146
-
-
Strong, MJ1
Grace, GM2
Freedman, M3
-
11
-
-
63749096466
-
High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
-
Corrado L, Ratti A, Gellera C, et al. High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis. Hum Mutat. 2009;30:688–694.
-
(2009)
Hum Mutat
, vol.30
, pp. 688-694
-
-
Corrado, L1
Ratti, A2
Gellera, C3
-
12
-
-
65649112431
-
TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
-
Benajiba L, Le Ber I, Camuzat A, et al. TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration. Ann Neurol. 2009; 65:470–473.
-
(2009)
Ann Neurol
, vol.65
, pp. 470-473
-
-
Benajiba, L1
Le Ber, I2
Camuzat, A3
-
13
-
-
77955395385
-
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
-
Tsai KJ, Yang CH, FangYH, et al. Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. J Exp Med. 2010;207:1661–1673.
-
(2010)
J Exp Med
, vol.207
, pp. 1661-1673
-
-
Tsai, KJ1
Yang, CH2
Fang, YH3
-
14
-
-
73949134014
-
Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)
-
Volkening K, Leystra-Lantz C, Yang W, Jaffee H, Strong MJ. Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). Brain Res. 2009;1305:168–182.
-
(2009)
Brain Res
, vol.1305
, pp. 168-182
-
-
Volkening, K1
Leystra-Lantz, C2
Yang, W3
Jaffee, H4
Strong, MJ.5
-
15
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009;323:1205–1208.
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski, TJ1
Bosco, DA2
Leclerc, AL3
-
16
-
-
62149141328
-
Rethinking ALS: the FUS about TDP-43
-
Lagier-Tourenne C, Cleveland DW. Rethinking ALS: the FUS about TDP-43. Cell. 2009;136:1001–1004.
-
(2009)
Cell
, vol.136
, pp. 1001-1004
-
-
Lagier-Tourenne, C1
Cleveland, DW.2
-
17
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
Vance C, Rogelj B, Hortobagyi T, et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009;323:1208–1211.
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C1
Rogelj, B2
Hortobagyi, T3
-
18
-
-
70350156915
-
Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort
-
Ticozzi N, Silani V, LeClerc AL, et al. Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort. Neurology. 2009;73:1180–1185.
-
(2009)
Neurology
, vol.73
, pp. 1180-1185
-
-
Ticozzi, N1
Silani, V2
LeClerc, AL3
-
19
-
-
77955093329
-
Fused in sarcoma/ translocated in liposarcoma: A multifunctional DNA/RNA binding protein
-
Yang S, Warraich ST, Nicholson GA, Blair IP. Fused in sarcoma/ translocated in liposarcoma: A multifunctional DNA/RNA binding protein. Int J Biochem Cell Biol. 2010;42:1408–1411.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 1408-1411
-
-
Yang, S1
Warraich, ST2
Nicholson, GA3
Blair, IP.4
-
20
-
-
79952717863
-
Numerous FUS-positive inclusions in an elderly woman with motor neuron disease
-
Fujita Y, Fujita S, Takatama M, Ikeda M, Okamoto K. Numerous FUS-positive inclusions in an elderly woman with motor neuron disease. Neuropathology. 2010. doi:10.1111/j.1440-1789.2010.01146.x.
-
(2010)
Neuropathology
-
-
Fujita, Y1
Fujita, S2
Takatama, M3
Ikeda, M4
Okamoto, K.5
-
21
-
-
38849117246
-
RNA-protein interactions and control of mRNA stability in neurons
-
Bolognani F, Perrone-Bizzozero NI. RNA-protein interactions and control of mRNA stability in neurons. J Neurosci Res. 2008;86: 481–489.
-
(2008)
J Neurosci Res
, vol.86
, pp. 481-489
-
-
Bolognani, F1
Perrone-Bizzozero, NI.2
-
22
-
-
33748949959
-
The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity
-
Deschenes-Furry J, Perrone-Bizzozero N, Jasmin BJ. The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity. Bioessays. 2006;28:822–833.
-
(2006)
Bioessays
, vol.28
, pp. 822-833
-
-
Deschenes-Furry, J1
Perrone-Bizzozero, N2
Jasmin, BJ.3
-
23
-
-
77951183978
-
Prion-like disorders: blurring the divide between transmissibility and infectivity
-
Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. J Cell Sci. 2010;123:1191–1201.
-
(2010)
J Cell Sci
, vol.123
, pp. 1191-1201
-
-
Cushman, M1
Johnson, BS2
King, OD3
Gitler, AD4
Shorter, J.5
-
24
-
-
80052636880
-
Mutational analysis of TARDBP in neurodegenerative diseases
-
Ticozzi N, Leclerc AL, van Blitterswijk M, et al. Mutational analysis of TARDBP in neurodegenerative diseases. Neurobiol Aging. 2009. doi:10.1016/j.neurobiolaging. 2009. 11.018.
-
(2009)
Neurobiol Aging
-
-
Ticozzi, N1
Leclerc, AL2
van Blitterswijk, M3
-
25
-
-
77649258646
-
A Drosophila model for TDP-43 proteinopathy
-
Li Y, Ray P, Rao EJ, et al. A Drosophila model for TDP-43 proteinopathy. Proc Natl Acad Sci U S A. 107:3169–3174.
-
Proc Natl Acad Sci U S A
, vol.107
, pp. 3169-3174
-
-
Li, Y1
Ray, P2
Rao, EJ3
-
26
-
-
77950421249
-
transgenic rat model of neurodegeneration caused by mutation in the TDP gene
-
Zhou H, Huang C, Chen H, et al. transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet. 2010;6:e1000887.
-
(2010)
PLoS Genet
, vol.6
, pp. e1000887
-
-
Zhou, H1
Huang, C2
Chen, H3
-
28
-
-
33745008403
-
The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain
-
Liu Z, Martin LJ. The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain. J Comp Neurol. 2006;497:468–488.
-
(2006)
J Comp Neurol
, vol.497
, pp. 468-488
-
-
Liu, Z1
Martin, LJ.2
-
29
-
-
77955661910
-
Neural precursor derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake
-
Diana V, Ottolina A, Botti F, et al. Neural precursor derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake. Exp Neurol. 2010. doi:10.1016/j. expneurol.2010.06.008.
-
(2010)
Exp Neurol
-
-
Diana, V1
Ottolina, A2
Botti, F3
-
30
-
-
77954563517
-
Metalloproteinase alterations in the bone marrow of ALS patients
-
Bossolasco P, Cova L, Calzarossa C, et al. Metalloproteinase alterations in the bone marrow of ALS patients. J Mol Med. 2010;88:553–564.
-
(2010)
J Mol Med
, vol.88
, pp. 553-564
-
-
Bossolasco, P1
Cova, L2
Calzarossa, C3
-
31
-
-
50149098605
-
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
-
Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008;321:1218–1221.
-
(2008)
Science
, vol.321
, pp. 1218-1221
-
-
Dimos, JT1
Rodolfa, KT2
Niakan, KK3
-
32
-
-
74949133926
-
Progress toward the clinical application of patientspecific pluripotent stem cells
-
Kiskinis E, Eggan K. Progress toward the clinical application of patientspecific pluripotent stem cells. J Clin Invest. 2010;120:51–59.
-
(2010)
J Clin Invest
, vol.120
, pp. 51-59
-
-
Kiskinis, E1
Eggan, K.2
-
33
-
-
68249087053
-
Variation in the safety of induced pluripotent stem cell lines
-
Miura K, Okada Y, Aoi T, et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol. 2009;27:743–745.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 743-745
-
-
Miura, K1
Okada, Y2
Aoi, T3
-
34
-
-
77955843524
-
Neurodegenerative disease-specific induced pluripotent stem cell research
-
Inoue H. Neurodegenerative disease-specific induced pluripotent stem cell research. Exp Cell Res. 2010. doi:10.1016/j.yexcr.2010.04.022.
-
(2010)
Exp Cell Res
-
-
Inoue, H.1
-
35
-
-
58249110796
-
Induced pluripotent stem cells from a spinal muscular atrophy patient
-
Ebert AD, Yu J, Rose FF Jr, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 2009;457:277–280.
-
(2009)
Nature
, vol.457
, pp. 277-280
-
-
Ebert, AD1
Yu, J2
Rose, FF3
-
36
-
-
70349301819
-
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
-
Lee G, Papapetrou EP, Kim H, et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature. 2009;461:402–406.
-
(2009)
Nature
, vol.461
, pp. 402-406
-
-
Lee, G1
Papapetrou, EP2
Kim, H3
-
37
-
-
77950902285
-
Stem cell tracking by nanotechnologies
-
Villa C, Erratico S, Razini P, et al. Stem cell tracking by nanotechnologies. Int J Mol Sci. 2010;11:1070–1081.
-
(2010)
Int J Mol Sci
, vol.11
, pp. 1070-1081
-
-
Villa, C1
Erratico, S2
Razini, P3
-
38
-
-
56549096129
-
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation
-
Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell. 2008;3:637–648.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 637-648
-
-
Di Giorgio, FP1
Boulting, GL2
Bobrowicz, S3
Eggan, KC.4
-
39
-
-
34247473080
-
Noncell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Noncell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci. 2007;10:608–614.
-
(2007)
Nat Neurosci
, vol.10
, pp. 608-614
-
-
Di Giorgio, FP1
Carrasco, MA2
Siao, MC3
Maniatis, T4
Eggan, K.5
-
40
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
Nagai M, Re DB, Nagata T, et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci. 2007;10:615–622.
-
(2007)
Nat Neurosci
, vol.10
, pp. 615-622
-
-
Nagai, M1
Re, DB2
Nagata, T3
-
41
-
-
63149148210
-
Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics
-
Weinberg MS, Wood MJ. Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics. Hum Mol Genet. 2009;18:R27–R39.
-
(2009)
Hum Mol Genet
, vol.18
, pp. R27-R39
-
-
Weinberg, MS1
Wood, MJ.2
-
42
-
-
71049166754
-
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
-
Strong MJ. The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS). J Neurol Sci. 2010;288:1–12.
-
(2010)
J Neurol Sci
, vol.288
, pp. 1-12
-
-
Strong, MJ.1
-
43
-
-
77955049511
-
Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells
-
Mallanna SK, Rizzino A. Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev Biol. 2010;344:16–25.
-
(2010)
Dev Biol
, vol.344
, pp. 16-25
-
-
Mallanna, SK1
Rizzino, A.2
-
44
-
-
72149131804
-
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
-
Williams AH, Valdez G, Moresi V, et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;326:1549–1554.
-
(2009)
Science
, vol.326
, pp. 1549-1554
-
-
Williams, AH1
Valdez, G2
Moresi, V3
-
45
-
-
77951700391
-
Nuclear factor TDP-43 can affect selected microRNA levels
-
Buratti E, de Conti L, Stuani C, Romano M, Baralle M, Baralle F. Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J. 2010;277:2268–2281.
-
(2010)
FEBS J
, vol.277
, pp. 2268-2281
-
-
Buratti, E1
de Conti, L2
Stuani, C3
Romano, M4
Baralle, M5
Baralle, F.6
-
48
-
-
1542378930
-
Glutamate receptors: RNA editing and death of motor neurons
-
Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S. Glutamate receptors: RNA editing and death of motor neurons. Nature. 2004;427:801.
-
(2004)
Nature
, vol.427
, pp. 801
-
-
Kawahara, Y1
Ito, K2
Sun, H3
Aizawa, H4
Kanazawa, I5
Kwak, S.6
-
49
-
-
34249946466
-
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
-
Mackenzie IR, Bigio EH, Ince PG, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol. 2007;61: 427–434.
-
(2007)
Ann Neurol
, vol.61
, pp. 427-434
-
-
Mackenzie, IR1
Bigio, EH2
Ince, PG3
-
50
-
-
33645798615
-
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
-
Kikuchi H, Almer G, Yamashita S, et al. Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A. 2006;103:6025–6030.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6025-6030
-
-
Kikuchi, H1
Almer, G2
Yamashita, S3
-
51
-
-
34547640096
-
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
-
Gruzman A, Wood WL, Alpert E, et al. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2007;104:12524–12529.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12524-12529
-
-
Gruzman, A1
Wood, WL2
Alpert, E3
-
53
-
-
0033934650
-
Serum markers of type I collagen synthesis and degradation in amyotrophic lateral sclerosis
-
Ono S, Imai T, Shimizu N, Nakayama M, Yamano T, Tsumura M. Serum markers of type I collagen synthesis and degradation in amyotrophic lateral sclerosis. Eur Neurol. 2000;44:49–56.
-
(2000)
Eur Neurol
, vol.44
, pp. 49-56
-
-
Ono, S1
Imai, T2
Shimizu, N3
Nakayama, M4
Yamano, T5
Tsumura, M.6
-
54
-
-
0028168970
-
Skin abnormalities and autonomic involvement in the early stage of amyotrophic lateral sclerosis
-
Provinciali L, Cangiotti A, Tulli D, Carboni V, Cinti S. Skin abnormalities and autonomic involvement in the early stage of amyotrophic lateral sclerosis. J Neurol Sci. 1994;126:54–61.
-
(1994)
J Neurol Sci
, vol.126
, pp. 54-61
-
-
Provinciali, L1
Cangiotti, A2
Tulli, D3
Carboni, V4
Cinti, S.5
-
55
-
-
0032497626
-
Collagen abnormalities in the spinal cord from patients with amyotrophic lateral sclerosis
-
Ono S, Imai T, Munakata S, et al. Collagen abnormalities in the spinal cord from patients with amyotrophic lateral sclerosis. J Neurol Sci. 1998;160:140–147.
-
(1998)
J Neurol Sci
, vol.160
, pp. 140-147
-
-
Ono, S1
Imai, T2
Munakata, S3
-
56
-
-
69549121754
-
Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)
-
Fang L, Huber-Abel F, Teuchert M, et al. Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS). J Neurol Sci. 2009;285:62–66.
-
(2009)
J Neurol Sci
, vol.285
, pp. 62-66
-
-
Fang, L1
Huber-Abel, F2
Teuchert, M3
-
57
-
-
33748466491
-
Matrix metalloproteinases – a conceptional alternative for disease-modifying strategies in ALS/MND?
-
Ludolph AC. Matrix metalloproteinases – a conceptional alternative for disease-modifying strategies in ALS/MND? Exp Neurol. 2006;201: 277–280.
-
(2006)
Exp Neurol
, vol.201
, pp. 277-280
-
-
Ludolph, AC.1
-
58
-
-
0034626855
-
Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis
-
Beuche W, Yushchenko M, Mader M, Maliszewska M, Felgenhauer K, Weber F. Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis. Neuroreport. 2000;11: 3419–3422.
-
(2000)
Neuroreport
, vol.11
, pp. 3419-3422
-
-
Beuche, W1
Yushchenko, M2
Mader, M3
Maliszewska, M4
Felgenhauer, K5
Weber, F.6
-
59
-
-
12344286247
-
The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis
-
Demestre M, Parkin-Smith G, Petzold A, Pullen AH. The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis. J Neuroimmunol. 2005; 159:146–154.
-
(2005)
J Neuroimmunol
, vol.159
, pp. 146-154
-
-
Demestre, M1
Parkin-Smith, G2
Petzold, A3
Pullen, AH.4
-
60
-
-
74549186988
-
Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
-
Niebroj-Dobosz I, Janik P, Sokolowska B, Kwiecinski H. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Eur J Neurol. 2010; 17:226–231.
-
(2010)
Eur J Neurol
, vol.17
, pp. 226-231
-
-
Niebroj-Dobosz, I1
Janik, P2
Sokolowska, B3
Kwiecinski, H.4
-
61
-
-
0033538970
-
Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle
-
Schoser BG, Blottner D. Matrix metalloproteinases MMP-2, MMP-7 and MMP-9 in denervated human muscle. Neuroreport. 1999; 10:2795–2797.
-
(1999)
Neuroreport
, vol.10
, pp. 2795-2797
-
-
Schoser, BG1
Blottner, D.2
-
62
-
-
0029922529
-
Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients
-
Lim GP, Backstrom JR, Cullen MJ, Miller CA, Atkinson RD, Tokes ZA. Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients. J Neurochem. 1996;67:251–259.
-
(1996)
J Neurochem
, vol.67
, pp. 251-259
-
-
Lim, GP1
Backstrom, JR2
Cullen, MJ3
Miller, CA4
Atkinson, RD5
Tokes, ZA.6
-
63
-
-
34247276120
-
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis
-
Kiaei M, Kipiani K, Calingasan NY, et al. Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2007;205:74–81.
-
(2007)
Exp Neurol
, vol.205
, pp. 74-81
-
-
Kiaei, M1
Kipiani, K2
Calingasan, NY3
-
64
-
-
33746072956
-
The matrix metalloproteinases inhibitor Ro 26-2853 extends survival in transgenic ALS mice
-
Lorenzl S, Narr S, Angele B, et al. The matrix metalloproteinases inhibitor Ro 26-2853 extends survival in transgenic ALS mice. Exp Neurol. 2006;200:166–171.
-
(2006)
Exp Neurol
, vol.200
, pp. 166-171
-
-
Lorenzl, S1
Narr, S2
Angele, B3
-
65
-
-
15944379637
-
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis
-
Dewil M, Schurmans C, Starckx S, Opdenakker G, van Den Bosch L, Robberecht W. Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis. Neuroreport. 2005;16:321–324.
-
(2005)
Neuroreport
, vol.16
, pp. 321-324
-
-
Dewil, M1
Schurmans, C2
Starckx, S3
Opdenakker, G4
van Den Bosch, L5
Robberecht, W.6
-
66
-
-
31744445961
-
Matrix metalloproteinases (MMPs) in health and disease: an overview
-
Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci. 2006;11:1696–1701.
-
(2006)
Front Biosci
, vol.11
, pp. 1696-1701
-
-
Malemud, CJ.1
-
67
-
-
41349122697
-
Dyslipidemia is a protective factor in amyotrophic lateral sclerosis
-
Dupuis L, Corcia P, Fergani A, et al. Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology. 2008;70:1004–1009.
-
(2008)
Neurology
, vol.70
, pp. 1004-1009
-
-
Dupuis, L1
Corcia, P2
Fergani, A3
-
68
-
-
34548145662
-
Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis
-
Fergani A, Oudart H, Gonzalez De Aguilar JL, et al. Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis. J Lipid Res. 2007;48:1571–1580.
-
(2007)
J Lipid Res
, vol.48
, pp. 1571-1580
-
-
Fergani, A1
Oudart, H2
Gonzalez De Aguilar, JL3
-
69
-
-
58149234264
-
Amyotrophic lateral sclerosis linked to a novel SOD1 mutation with muscle mitochondrial dysfunction
-
Corti S, Donadoni C, Ronchi D, et al. Amyotrophic lateral sclerosis linked to a novel SOD1 mutation with muscle mitochondrial dysfunction. J Neurol Sci. 2009;276:170–174.
-
(2009)
J Neurol Sci
, vol.276
, pp. 170-174
-
-
Corti, S1
Donadoni, C2
Ronchi, D3
-
70
-
-
65949094823
-
Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models
-
Dupuis L, Loeffler JP. Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models. Curr Opin Pharmacol. 2009;9:341–346.
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 341-346
-
-
Dupuis, L1
Loeffler, JP.2
-
71
-
-
9644279692
-
Stem-cell therapy in amyotrophic lateral sclerosis
-
Mazzini L, Fagioli F, Boccaletti R. Stem-cell therapy in amyotrophic lateral sclerosis. Lancet. 2004;364:1936–1937.
-
(2004)
Lancet
, vol.364
, pp. 1936-1937
-
-
Mazzini, L1
Fagioli, F2
Boccaletti, R.3
-
73
-
-
77950858200
-
Mesenchymal Stem Cell Transplantation In Amyotrophic Lateral Sclerosis: A Phase I Clinical Trial
-
Mazzini L, Ferrero I, Luparello V, et al. Mesenchymal Stem Cell Transplantation In Amyotrophic Lateral Sclerosis: A Phase I Clinical Trial. Exp Neurol. 2009. doi:10.1016/j.expneurol.2009.08.007.
-
(2009)
Exp Neurol
-
-
Mazzini, L1
Ferrero, I2
Luparello, V3
-
74
-
-
33746472915
-
Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis
-
Mazzini L, Mareschi K, Ferrero I, et al. Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis. Neurol Res. 2006;28:523–526.
-
(2006)
Neurol Res
, vol.28
, pp. 523-526
-
-
Mazzini, L1
Mareschi, K2
Ferrero, I3
-
75
-
-
37849022487
-
Stem cell treatment in Amyotrophic Lateral Sclerosis
-
Mazzini L, Mareschi K, Ferrero I, et al. Stem cell treatment in Amyotrophic Lateral Sclerosis. J Neurol Sci. 2008;265:78–83.
-
(2008)
J Neurol Sci
, vol.265
, pp. 78-83
-
-
Mazzini, L1
Mareschi, K2
Ferrero, I3
-
76
-
-
34547858511
-
Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons
-
Lee H, Shamy GA, Elkabetz Y, et al. Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells. 2007;25:1931–1939.
-
(2007)
Stem Cells
, vol.25
, pp. 1931-1939
-
-
Lee, H1
Shamy, GA2
Elkabetz, Y3
-
77
-
-
13844271605
-
Specification of motoneurons from human embryonic stem cells
-
Li XJ, Du ZW, Zarnowska ED, et al. Specification of motoneurons from human embryonic stem cells. Nat Biotechnol. 2005;23:215–221.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 215-221
-
-
Li, XJ1
Du, ZW2
Zarnowska, ED3
-
78
-
-
45849146018
-
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
-
Li XJ, Hu BY, Jones SA, et al. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells. 2008;26:886–893.
-
(2008)
Stem Cells
, vol.26
, pp. 886-893
-
-
Li, XJ1
Hu, BY2
Jones, SA3
-
79
-
-
27744438009
-
Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
-
Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol. 2005;196: 224–234.
-
(2005)
Exp Neurol
, vol.196
, pp. 224-234
-
-
Singh Roy, N1
Nakano, T2
Xuing, L3
Kang, J4
Nedergaard, M5
Goldman, SA.6
-
80
-
-
0037047320
-
Directed differentiation of embryonic stem cells into motor neurons
-
Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell. 2002;110: 385–397.
-
(2002)
Cell
, vol.110
, pp. 385-397
-
-
Wichterle, H1
Lieberam, I2
Porter, JA3
Jessell, TM.4
-
81
-
-
4544251998
-
Functional properties of motoneurons derived from mouse embryonic stem cells
-
Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, Brownstone RM. Functional properties of motoneurons derived from mouse embryonic stem cells. J Neurosci. 2004;24:7848–7858.
-
(2004)
J Neurosci
, vol.24
, pp. 7848-7858
-
-
Miles, GB1
Yohn, DC2
Wichterle, H3
Jessell, TM4
Rafuse, VF5
Brownstone, RM.6
-
82
-
-
33745686121
-
Recovery from paralysis in adult rats using embryonic stem cells
-
Deshpande DM, Kim YS, Martinez T, et al. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol. 2006;60: 32–44.
-
(2006)
Ann Neurol
, vol.60
, pp. 32-44
-
-
Deshpande, DM1
Kim, YS2
Martinez, T3
-
83
-
-
2342472526
-
Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats
-
Harper JM, Krishnan C, Darman JS, et al. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci U S A. 2004;101:7123–7128.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7123-7128
-
-
Harper, JM1
Krishnan, C2
Darman, JS3
-
84
-
-
34748861854
-
Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons
-
Gaillard A, Prestoz L, Dumartin B, et al. Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons. Nat Neurosci. 2007;10:1294–1299.
-
(2007)
Nat Neurosci
, vol.10
, pp. 1294-1299
-
-
Gaillard, A1
Prestoz, L2
Dumartin, B3
-
85
-
-
67349135648
-
Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord
-
Emgard M, Holmberg L, Samuelsson EB, et al. Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord. Brain Res. 2009;1278:15–26.
-
(2009)
Brain Res
, vol.1278
, pp. 15-26
-
-
Emgard, M1
Holmberg, L2
Samuelsson, EB3
-
86
-
-
34249900697
-
Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy
-
Capowski EE, Schneider BL, Ebert AD, et al. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. J Neurosci Methods. 2007;163:338–349.
-
(2007)
J Neurosci Methods
, vol.163
, pp. 338-349
-
-
Capowski, EE1
Schneider, BL2
Ebert, AD3
-
87
-
-
18444381777
-
GDNF delivery using human neural progenitor cells in a rat model of ALS
-
Klein SM, Behrstock S, McHugh J, et al. GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum Gene Ther. 2005;16:509–521.
-
(2005)
Hum Gene Ther
, vol.16
, pp. 509-521
-
-
Klein, SM1
Behrstock, S2
McHugh, J3
-
88
-
-
74849112075
-
Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis
-
Thonhoff JR, Ojeda L, Wu P. Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. Curr Stem Cell Res Ther. 2009;4:178–199.
-
(2009)
Curr Stem Cell Res Ther
, vol.4
, pp. 178-199
-
-
Thonhoff, JR1
Ojeda, L2
Wu, P.3
-
89
-
-
77249088647
-
Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice
-
Corti S, Nizzardo M, Nardini M, et al. Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice. Brain. 2010;133:465–481.
-
(2010)
Brain
, vol.133
, pp. 465-481
-
-
Corti, S1
Nizzardo, M2
Nardini, M3
-
90
-
-
58149381448
-
Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy
-
Yohn DC, Miles GB, Rafuse VF, Brownstone RM. Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy. J Neurosci. 2008;28:12409–12418.
-
(2008)
J Neurosci
, vol.28
, pp. 12409-12418
-
-
Yohn, DC1
Miles, GB2
Rafuse, VF3
Brownstone, RM.4
-
91
-
-
34249674380
-
Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model
-
Corti S, Locatelli F, Papadimitriou D, et al. Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model. Brain. 2007;130:1289–1305.
-
(2007)
Brain
, vol.130
, pp. 1289-1305
-
-
Corti, S1
Locatelli, F2
Papadimitriou, D3
-
92
-
-
70349485394
-
Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1)
-
Corti S, Nizzardo M, Nardini M, et al. Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). J Neurosci. 2009;29:11761–11771.
-
(2009)
J Neurosci
, vol.29
, pp. 11761-11771
-
-
Corti, S1
Nizzardo, M2
Nardini, M3
-
93
-
-
55849119559
-
Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy
-
Corti S, Nizzardo M, Nardini M, et al. Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy. J Clin Invest. 2008;118:3316–3330.
-
(2008)
J Clin Invest
, vol.118
, pp. 3316-3330
-
-
Corti, S1
Nizzardo, M2
Nardini, M3
-
94
-
-
74949087489
-
Stem cells in human neurodegenerative disorders – time for clinical translation?
-
Lindvall O, Kokaia Z. Stem cells in human neurodegenerative disorders – time for clinical translation? J Clin Invest. 2010;120:29–40.
-
(2010)
J Clin Invest
, vol.120
, pp. 29-40
-
-
Lindvall, O1
Kokaia, Z.2
-
95
-
-
52449117926
-
Research in motion: the enigma of Parkinson’s disease pathology spread
-
Brundin P, Li JY, Holton JL, Lindvall O, Revesz T. Research in motion: the enigma of Parkinson’s disease pathology spread. Nat Rev Neurosci. 2008;9:741–745.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 741-745
-
-
Brundin, P1
Li, JY2
Holton, JL3
Lindvall, O4
Revesz, T.5
-
96
-
-
0141642203
-
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
-
Clement AM, Nguyen MD, Roberts EA, et al. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 2003;302:113–117.
-
(2003)
Science
, vol.302
, pp. 113-117
-
-
Clement, AM1
Nguyen, MD2
Roberts, EA3
-
97
-
-
44649152645
-
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
-
Yamanaka K, Boillee S, Roberts EA, et al. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A. 2008;105: 7594–7599.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7594-7599
-
-
Yamanaka, K1
Boillee, S2
Roberts, EA3
-
98
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
Yamanaka K, Chun SJ, Boillee S, et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci. 2008;11:251–253.
-
(2008)
Nat Neurosci
, vol.11
, pp. 251-253
-
-
Yamanaka, K1
Chun, SJ2
Boillee, S3
-
99
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
Boillee S, Yamanaka K, Lobsiger CS, et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 2006;312:1389–1392.
-
(2006)
Science
, vol.312
, pp. 1389-1392
-
-
Boillee, S1
Yamanaka, K2
Lobsiger, CS3
-
100
-
-
34848923327
-
Cell therapy and stem cells in animal models of motor neuron disorders
-
Hedlund E, Hefferan MP, Marsala M, Isacson O. Cell therapy and stem cells in animal models of motor neuron disorders. Eur J Neurosci. 2007;26:1721–1737.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 1721-1737
-
-
Hedlund, E1
Hefferan, MP2
Marsala, M3
Isacson, O.4
-
101
-
-
56549115885
-
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells
-
Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008;3:649–657.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 649-657
-
-
Marchetto, MC1
Muotri, AR2
Mu, Y3
Smith, AM4
Cezar, GG5
Gage, FH.6
-
102
-
-
20244381261
-
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
-
Ralph GS, Radcliffe PA, Day DM, et al. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat Med. 2005;11:429–433.
-
(2005)
Nat Med
, vol.11
, pp. 429-433
-
-
Ralph, GS1
Radcliffe, PA2
Day, DM3
-
103
-
-
17644383664
-
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
-
Raoul C, Abbas-Terki T, Bensadoun JC, et al. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med. 2005;11: 423–428.
-
(2005)
Nat Med
, vol.11
, pp. 423-428
-
-
Raoul, C1
Abbas-Terki, T2
Bensadoun, JC3
-
104
-
-
77951879452
-
Human stem cells and drug screening: opportunities and challenges
-
Ebert AD, Svendsen CN. Human stem cells and drug screening: opportunities and challenges. Nat Rev Drug Discov. 2010;9:367–372.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 367-372
-
-
Ebert, AD1
Svendsen, CN.2
-
105
-
-
69149108013
-
Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
-
Karumbayaram S, Kelly TK, Paucar AA, et al. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis Model Mech. 2009;2:189–195.
-
(2009)
Dis Model Mech
, vol.2
, pp. 189-195
-
-
Karumbayaram, S1
Kelly, TK2
Paucar, AA3
-
106
-
-
55049120934
-
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
-
Gowing G, Philips T, van Wijmeersch B, et al. Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J Neurosci. 2008;28:10234–10244.
-
(2008)
J Neurosci
, vol.28
, pp. 10234-10244
-
-
Gowing, G1
Philips, T2
van Wijmeersch, B3
-
107
-
-
70349389656
-
Stem cells in amyotrophic lateral sclerosis: state of the art
-
Mazzini L, Vercelli A, Ferrero I, et al. Stem cells in amyotrophic lateral sclerosis: state of the art. Expert Opin Biol Ther. 2009;9: 1245–1258.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 1245-1258
-
-
Mazzini, L1
Vercelli, A2
Ferrero, I3
-
108
-
-
55749110043
-
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
-
Beers DR, Henkel JS, Zhao W, Wang J, Appel SH. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc Natl Acad Sci U S A. 2008;105:15558–15563.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 15558-15563
-
-
Beers, DR1
Henkel, JS2
Zhao, W3
Wang, J4
Appel, SH.5
-
109
-
-
36148931797
-
Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects
-
Habisch HJ, Janowski M, Binder D, et al. Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm. 2007;114:1395–1406.
-
(2007)
J Neural Transm
, vol.114
, pp. 1395-1406
-
-
Habisch, HJ1
Janowski, M2
Binder, D3
-
110
-
-
72549101159
-
Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice
-
Kim H, Kim HY, Choi MR, et al. Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice. Neurosci Lett. 468:190–194.
-
Neurosci Lett
, vol.468
, pp. 190-194
-
-
Kim, H1
Kim, HY2
Choi, MR3
-
111
-
-
65649090629
-
Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry
-
Xu L, Ryugo DK, Pongstaporn T, Johe K, Koliatsos VE. Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry. J Comp Neurol. 2009;514:297–309.
-
(2009)
J Comp Neurol
, vol.514
, pp. 297-309
-
-
Xu, L1
Ryugo, DK2
Pongstaporn, T3
Johe, K4
Koliatsos, VE.5
-
112
-
-
55449090370
-
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
-
Appel SH, Engelhardt JI, Henkel JS, et al. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology. 2008;71:1326–1334.
-
(2008)
Neurology
, vol.71
, pp. 1326-1334
-
-
Appel, SH1
Engelhardt, JI2
Henkel, JS3
-
113
-
-
37549065020
-
GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS
-
Suzuki M, McHugh J, Tork C, et al. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS One. 2007;2:e689.
-
(2007)
PLoS One
, vol.2
, pp. e689
-
-
Suzuki, M1
McHugh, J2
Tork, C3
-
114
-
-
41249086987
-
Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis
-
Suzuki M, Svendsen CN. Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis. Trends Neurosci. 2008;31:192–198.
-
(2008)
Trends Neurosci
, vol.31
, pp. 192-198
-
-
Suzuki, M1
Svendsen, CN.2
-
115
-
-
68049110630
-
Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
-
Park S, Kim HT, Yun S, et al. Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice. Exp Mol Med. 2009;41:487–500.
-
(2009)
Exp Mol Med
, vol.41
, pp. 487-500
-
-
Park, S1
Kim, HT2
Yun, S3
-
116
-
-
54949126674
-
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
-
Lepore AC, Rauck B, Dejea C, et al. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci. 2008;11:1294–1301.
-
(2008)
Nat Neurosci
, vol.11
, pp. 1294-1301
-
-
Lepore, AC1
Rauck, B2
Dejea, C3
-
117
-
-
0037022339
-
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
-
Howland DS, Liu J, She Y, et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2002;99: 1604–1609.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 1604-1609
-
-
Howland, DS1
Liu, J2
She, Y3
-
118
-
-
1642371041
-
Altered expression of the glutamate transporter EAAT2b in neurological disease
-
Maragakis NJ, Dykes-Hoberg M, Rothstein JD. Altered expression of the glutamate transporter EAAT2b in neurological disease. Ann Neurol. 2004;55:469–477.
-
(2004)
Ann Neurol
, vol.55
, pp. 469-477
-
-
Maragakis, NJ1
Dykes-Hoberg, M2
Rothstein, JD.3
-
119
-
-
77949273896
-
Human adipose-derived stem cells enhance the glutamate uptake function of GLT1 in SOD1(G93A)-bearing astrocytes
-
Gu R, Hou X, Pang R, et al. Human adipose-derived stem cells enhance the glutamate uptake function of GLT1 in SOD1(G93A)-bearing astrocytes. Biochem Biophys Res Commun. 2010;393:481–486.
-
(2010)
Biochem Biophys Res Commun
, vol.393
, pp. 481-486
-
-
Gu, R1
Hou, X2
Pang, R3
-
120
-
-
77956524950
-
Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis
-
Corti S, Nizzardo M, Nardini M, et al. Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Hum Mol Genet. 2010. doi:10.1093/hmg/ddq293.
-
(2010)
Hum Mol Genet
-
-
Corti, S1
Nizzardo, M2
Nardini, M3
-
121
-
-
8144229995
-
Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
-
Corti S, Locatelli F, Donadoni C, et al. Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain. 2004;127: 2518–2532.
-
(2004)
Brain
, vol.127
, pp. 2518-2532
-
-
Corti, S1
Locatelli, F2
Donadoni, C3
-
122
-
-
33750478657
-
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
-
Beers DR, Henkel JS, Xiao Q, et al. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006;103:16021–16026.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 16021-16026
-
-
Beers, DR1
Henkel, JS2
Xiao, Q3
-
123
-
-
70349265930
-
Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
-
Ohnishi S, Ito H, Suzuki Y, et al. Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis. Brain Res. 2009;1296:216–224.
-
(2009)
Brain Res
, vol.1296
, pp. 216-224
-
-
Ohnishi, S1
Ito, H2
Suzuki, Y3
-
124
-
-
62149133010
-
Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients
-
Martinez HR, Gonzalez-Garza MT, Moreno-Cuevas JE, Caro E, Gutierrez-Jimenez E, Segura JJ. Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy. 2009;11:26–34.
-
(2009)
Cytotherapy
, vol.11
, pp. 26-34
-
-
Martinez, HR1
Gonzalez-Garza, MT2
Moreno-Cuevas, JE3
Caro, E4
Gutierrez-Jimenez, E5
Segura, JJ.6
-
125
-
-
62149135220
-
Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up
-
Deda H, Inci MC, Kurekci AE, et al. Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy. 2009;11: 18–25.
-
(2009)
Cytotherapy
, vol.11
, pp. 18-25
-
-
Deda, H1
Inci, MC2
Kurekci, AE3
-
126
-
-
9244251031
-
Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice
-
Chen J, Magavi SS, Macklis JD. Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice. Proc Natl Acad Sci U S A. 2004;101:16357–16362.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 16357-16362
-
-
Chen, J1
Magavi, SS2
Macklis, JD.3
-
127
-
-
33845908991
-
Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopoietic function
-
Erie EA, Shim H, Smith AL, et al. Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopoietic function. J Neuroimmunol. 2007;182:226–231.
-
(2007)
J Neuroimmunol
, vol.182
, pp. 226-231
-
-
Erie, EA1
Shim, H2
Smith, AL3
-
128
-
-
34548500097
-
Temporal response of neural progenitor cells to disease onset and progression in amyotrophic lateral sclerosis-like transgenic mice
-
Chi L, Gan L, Luo C, Lien L, Liu R. Temporal response of neural progenitor cells to disease onset and progression in amyotrophic lateral sclerosis-like transgenic mice. Stem Cells Dev. 2007;16:579–588.
-
(2007)
Stem Cells Dev
, vol.16
, pp. 579-588
-
-
Chi, L1
Gan, L2
Luo, C3
Lien, L4
Liu, R.5
-
129
-
-
73049087960
-
Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson’s disease
-
Cova L, Armentero MT, Zennaro E, et al. Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson’s disease. Brain Res. 2010;1311:12–27.
-
(2010)
Brain Res
, vol.1311
, pp. 12-27
-
-
Cova, L1
Armentero, MT2
Zennaro, E3
-
130
-
-
59749084201
-
Feasibility of cell therapy for amyotrophic lateral sclerosis
-
Garbuzova-Davis S, Sanberg PR. Feasibility of cell therapy for amyotrophic lateral sclerosis. Exp Neurol. 2009;216:3–6.
-
(2009)
Exp Neurol
, vol.216
, pp. 3-6
-
-
Garbuzova-Davis, S1
Sanberg, PR.2
-
131
-
-
77953930266
-
Stem cell renegades or pioneers?
-
Gornall J. Stem cell renegades or pioneers? BMJ. 2010;340:c2041.
-
(2010)
BMJ
, vol.340
, pp. c2041
-
-
Gornall, J.1
-
132
-
-
70349730271
-
Cervical spinal cord therapeutics delivery: preclinical safety validation of a stabilized microinjection platform
-
discussion 761–752
-
Riley J, Federici T, Park J, et al. Cervical spinal cord therapeutics delivery: preclinical safety validation of a stabilized microinjection platform. Neurosurgery. 2009;65:754–761; discussion 761–752.
-
(2009)
Neurosurgery
, vol.65
, pp. 754-761
-
-
Riley, J1
Federici, T2
Park, J3
-
133
-
-
33749872454
-
Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
-
Xu L, Yan J, Chen D, et al. Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation. 2006;82:865–875.
-
(2006)
Transplantation
, vol.82
, pp. 865-875
-
-
Xu, L1
Yan, J2
Chen, D3
-
134
-
-
34250370522
-
Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells
-
Cizkova D, Kakinohana O, Kucharova K, et al. Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. Neuroscience. 2007;147:546–560.
-
(2007)
Neuroscience
, vol.147
, pp. 546-560
-
-
Cizkova, D1
Kakinohana, O2
Kucharova, K3
-
135
-
-
42549085246
-
Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)
-
Cashman N, Tan LY, Krieger C, et al. Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS). Muscle Nerve. 2008;37:620–625.
-
(2008)
Muscle Nerve
, vol.37
, pp. 620-625
-
-
Cashman, N1
Tan, LY2
Krieger, C3
-
136
-
-
0035685888
-
Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis
-
Janson CG, Ramesh TM, During MJ, Leone P, Heywood J. Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis. J Hematother Stem Cell Res. 2001;10:913–915.
-
(2001)
J Hematother Stem Cell Res
, vol.10
, pp. 913-915
-
-
Janson, CG1
Ramesh, TM2
During, MJ3
Leone, P4
Heywood, J.5
-
137
-
-
54049157847
-
Is it too soon for mesenchymal stem cell trials in people with ALS?
-
Badayan I, Cudkowicz ME. Is it too soon for mesenchymal stem cell trials in people with ALS? Amyotroph Lateral Scler. 2008;9:321–322.
-
(2008)
Amyotroph Lateral Scler
, vol.9
, pp. 321-322
-
-
Badayan, I1
Cudkowicz, ME.2
-
138
-
-
3042837514
-
Stem-cell therapy for amyotrophic lateral sclerosis
-
Silani V, Cova L, Corbo M, Ciammola A, Polli E. Stem-cell therapy for amyotrophic lateral sclerosis. Lancet. 2004;364:200–202.
-
(2004)
Lancet
, vol.364
, pp. 200-202
-
-
Silani, V1
Cova, L2
Corbo, M3
Ciammola, A4
Polli, E.5
-
139
-
-
44949100577
-
Short-term outcome of olfactory ensheathing cells transplantation for treatment of amyotrophic lateral sclerosis
-
Chen L, Huang H, Zhang J, et al. Short-term outcome of olfactory ensheathing cells transplantation for treatment of amyotrophic lateral sclerosis. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007;21: 961–966.
-
(2007)
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
, vol.21
, pp. 961-966
-
-
Chen, L1
Huang, H2
Zhang, J3
-
140
-
-
56349111924
-
Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study
-
Huang H, Chen L, Xi H, et al. Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study. Clin Transplant. 2008;22:710–718.
-
(2008)
Clin Transplant
, vol.22
, pp. 710-718
-
-
Huang, H1
Chen, L2
Xi, H3
-
141
-
-
66849083487
-
Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients
-
Huang H, Chen L, Xi H, et al. Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009;23:14–20.
-
(2009)
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
, vol.23
, pp. 14-20
-
-
Huang, H1
Chen, L2
Xi, H3
-
142
-
-
35148825568
-
Olfactory ensheathing glia injections in Beijing: misleading patients with ALS
-
Chew S, Khandji AG, Montes J, Mitsumoto H, Gordon PH. Olfactory ensheathing glia injections in Beijing: misleading patients with ALS. Amyotroph Lateral Scler. 2007;8:314–316.
-
(2007)
Amyotroph Lateral Scler
, vol.8
, pp. 314-316
-
-
Chew, S1
Khandji, AG2
Montes, J3
Mitsumoto, H4
Gordon, PH.5
-
143
-
-
77955769342
-
A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis
-
Blanquer M, Perez-Espejo MA, Martinez-Lage JF, Iniesta F, Martinez S, Moraleda JM. A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis. J Neurosci Methods. 2010. doi:10.1016/j.jneumeth.2010.06.014.
-
(2010)
J Neurosci Methods
-
-
Blanquer, M1
Perez-Espejo, MA2
Martinez-Lage, JF3
Iniesta, F4
Martinez, S5
Moraleda, JM.6
-
144
-
-
28544446960
-
Autologous olfactory ensheathing cell transplantation in human spinal cord injury
-
Feron F, Perry C, Cochrane J, et al. Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain. 2005;128:2951–2960.
-
(2005)
Brain
, vol.128
, pp. 2951-2960
-
-
Feron, F1
Perry, C2
Cochrane, J3
|