Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells

Hepatology Research

Volumn 41, Issue 4, 2011, Pages 364-374

  Miyachi, Hirohide ^a   Kobayashi, Yoshinao ^a   Relja, Borna ^a,b   Fujita, Naoki ^a   Iwasa, Motoh ^a   Gabazza, Esteban Cesar ^a   Takei, Yoshiyuki ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Hepatitis C virus; Hepcidin; Iron metabolism; Replicon; Suppressor of cytokine signaling

Indexed keywords

HEPCIDIN; INTERLEUKIN 6; MESSENGER RNA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ARTICLE; ENZYME INHIBITION; GENE EXPRESSION; GENE SILENCING; HEPATITIS C; HEPATITIS C VIRUS; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; VIRAL GENETICS; WESTERN BLOTTING;

EID: 79952823437     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00777.x     Document Type: Article

References (39)

1. Fujita N, Takei Y. Iron, hepatitis C virus, and hepatocellular carcinoma: iron reduction preaches the gospel for chronic hepatitis C. J Gastroenterol 2007; 42: 923-6.
2. Krause A, Neitz S, Mägert HJ etal. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000; 480: 147-50.
3. Nemeth E, Tuttle MS, Powelson J etal. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090-3.
4. Loréal O, Haziza-Pigeon C, Troadec MB etal. Hepcidin in iron metabolism. Curr Protein Pept Sci 2005; 6: 279-91.
5. Nicolas G, Bennoun M, Devaux I etal. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001; 98: 8780-5.
6. Deugnier Y, Brissot P, Loreal O. Iron and the liver: update 2008. J Hepatol 2008; 48: S113-23.
7. Calzolari A, Raggi C, Deaglio S etal. TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway. J Cell Sci 2006; 119: 4486-98.
8. Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 2008; 7: 205-14.
9. Fleming RE. Iron sensing as a partnership: HFE and transferrin receptor 2. Cell Metab 2009; 9: 211-2.
10. Wang RH, Li C, Xu X etal. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005; 2: 399-409.
11. Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA 2006; 103: 10289-93.
12. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006; 108: 3204-9.
13. Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007; 109: 353-8.
14. Matak P, Chaston TB, Chung B, Srai SK, McKie AT, Sharp PA. Activated macrophages induce hepcidin expression in HuH7 hepatoma cells. Haematologica 2009; 94: 773-80.
15. Starr R, Willson TA, Viney EM etal. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387: 917-21.
16. Endo TA, Masuhara M, Yokouchi M etal. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997; 387: 921-4.
17. Naka T, Narazaki M, Hirata M etal. Structure and function of a new STAT-induced STAT inhibitor. Nature 1997; 387: 924-9.
18. Miyoshi H, Fujie H, Shintani Y etal. Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression. J Hepatol 2005; 43: 757-63.
19. Fujita N, Sugimoto R, Takeo M etal. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007; 13: 97-104.
20. Blight KJ, McKeating JA, Rice CM. Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 2002; 76: 13001-14.
21. Fujita N, Sugimoto R, Motonishi S etal. Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol 2008; 49: 702-10.
22. Nishina S, Hino K, Korenaga M etal. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-38.
23. Moriya K, Miyoshi H, Shinzawa S etal. Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells. J Med Virol 2010; 82: 776-92.
24. Vecchi C, Montosi G, Pietrangelo A. Huh-7: a human "hemochromatotic" cell line. Hepatology 2010; 51: 654-9.
25. Matak P, Chaston TB, Chung B, Srai SK, McKie AT, Sharp PA. Activated macrophages induce hepcidin expression in HuH7 hepatoma cells. Haematologica 2009; 94: 773-80.
26. Trinder D, Ayonrinde OT, Olynyk JK. HCV, iron, and oxidative stress: the new choreography of hepcidin. Gastroenterology 2008; 134: 348-51.
27. Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008; 48: 1420-9.
28. Yao ZQ, Prayther D, Trabue C, Dong ZP, Moorman J. Differential regulation of SOCS-1 signalling in B and T lymphocytes by hepatitis C virus core protein. Immunology 2008; 125: 197-207.
29. Moorman J, Dong ZP, Ni L, Zhang C, Borthwick T, Yao ZQ. Abnormal B-cell activation associated with TALL-1 over-expression and SOCS-1 suppression during chronic hepatitis C virus infection. Immunology 2009; 128: 227-35.
30. Machado MV, Cortez-Pinto H. Insulin resistance and steatosis in chronic hepatitis C. Ann Hepatol 2009; 8: S67-75.
31. Ramadoss P, Unger-Smith NE, Lam FS, Hollenberg AN. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. Mol Endocrinol 2009; 23: 827-37.
32. Vecchi C, Montosi G, Zhang K etal. ER stress controls iron metabolism through induction of hepcidin. Science 2009; 325: 877-80.
33. Tardif KD, Mori K, Siddiqui A. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J Virol 2002; 76: 7453-9.
34. Duvet S, Cocquerel L, Pillez A etal. Hepatitis C virus glycoprotein complex localization in the endoplasmic reticulum involves a determinant for retention and not retrieval. J Biol Chem 1998; 273: 32088-95.
35. Sheikh MY, Choi J, Qadri I, Friedman JE, Sanyal AJ. Hepatitis C virus infection: molecular pathways to metabolic syndrome. Hepatology 2008; 47: 2127-33.
36. Malaguarnera M, Di Fazio I, Romeo MA, Restuccia S, Laurino A, Trovato BA. Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus. J Gastroenterol 1997; 32: 211-5.
37. Falasca K, Mancino P, Ucciferri C etal. Inflammatory cytokines and S-100b protein in patients with hepatitis C infection and cryoglobulinemias. Clin Invest Med 2007; 30: E167-76.
38. Antonelli A, Ferri C, Ferrari SM etal. High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemia. Clin Rheumatol 2009; 28: 1179-85.
39. Chung CD, Liao J, Liu B etal. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997; 278: 1803-5.